Methods and apparatus for determining a central aortic pressure waveform from a peripheral artery pressure waveform
First Claim
1. A method for determining a central aortic pressure (AP) waveform for a subject, comprising:
- measuring, by a sensor, a peripheral artery pressure (PAP) waveform from the subject;
deriving a mathematical transformation relating PAP to AP using a distributed model, the transformation is defined in terms of unknown parameters;
estimating, by a computing device, the unknown parameters by minimizing a variable representing a magnitude of central arterial flow during diastole when applied to the PAP waveform, wherein estimating the unknown parameters uses only one PAP waveform measured from the subject; and
determining, by the computing device, the AP waveform for the subject by applying the derived mathematical transformation to the measured AP, where the steps of estimating and determining are implement by computer-executable instructions executed by a computer processor of the computing device.
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Abstract
A method is provided for determining a central aortic pressure (AP) wave-form for a subject. The method includes measuring a peripheral artery pressure (PAP) waveform from the subject, employing a distributed model to define a pressure-to-pressure transfer function relating PAP to AP and a pressure-to-flow transfer function relating PAP to a central arterial flow in terms of the same unknown parameters, estimating the unknown parameters by finding the pressure-to-flow transfer function, which when applied to the measured PAP waveform, minimizes the magnitude of the central arterial flow waveform during diastole, and applying the pressure-to-pressure transfer function with the estimated parameters to determine an AP waveform for the subject.
13 Citations
54 Claims
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1. A method for determining a central aortic pressure (AP) waveform for a subject, comprising:
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measuring, by a sensor, a peripheral artery pressure (PAP) waveform from the subject; deriving a mathematical transformation relating PAP to AP using a distributed model, the transformation is defined in terms of unknown parameters; estimating, by a computing device, the unknown parameters by minimizing a variable representing a magnitude of central arterial flow during diastole when applied to the PAP waveform, wherein estimating the unknown parameters uses only one PAP waveform measured from the subject; and determining, by the computing device, the AP waveform for the subject by applying the derived mathematical transformation to the measured AP, where the steps of estimating and determining are implement by computer-executable instructions executed by a computer processor of the computing device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for determining a central aortic pressure (AP) waveform for a subject, comprising:
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measuring, by a sensor, a peripheral artery pressure (PAP) waveform from the subject; employing a distributed model to define a pressure-to-pressure transfer function relating PAP to AP and a pressure-to-flow transfer function relating PAP to a central arterial flow in terms of the same unknown parameters; estimating, by a computing device, the unknown parameters by finding the pressure-to-flow transfer function, which when applied to the measured PAP waveform, minimizes a variable representing a magnitude of the central arterial flow waveform during diastole, wherein estimating the unknown parameters uses only one PAP waveform from the subject; and applying, by the computing device, the pressure-to-pressure transfer function with the estimated parameters to determine an AP waveform for the subject, where the steps of estimating and determining are implemented by computer-executable instructions executed by a computer processor of the computing devices. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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54. A system for determining a central aortic pressure (AP) waveform for a subject, comprising:
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a sensor configured to obtain a peripheral artery pressure (PAP) waveform from the subject; a parameter estimation module that estimates unknown parameters of a pressure-to-flow transfer function, from only one PAP wavefrom, by minimizing a variable representing central arterial flow during diastole when the pressure-to-flow transfer function is applied to the PAP waveform, where the pressure-to-flow transfer function relates PAP to a central arterial flow in terms of the unknown parameters; and a waveform estimation module that applies a pressure-to-pressure transfer function with the estimated parameters to the PAP waveform to determine an AP waveform for the subject, where the pressure-to-pressure transfer function relates PAP to AP in terms of the same unknown parameters, where the parameter estimation module and the waveform estimation module are implemented by computer-executable instructions executed by a computer processor of a computing device.
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Specification