Method and apparatus for correction of non-invasive blood glucose measurement

• US 10,251,584 B2
• Filed: 11/25/2016
• Issued: 04/09/2019
• Est. Priority Date: 12/09/2015
• Status: Active Grant

• Current Assignee: Iism Inc.
• Original Assignee: Iism Inc.
• Inventors: Jin, Seung Min, Yang, Il Seung, Bae, Yun Mi, Park, Seong Oak, Kim, Yu Sic, Choi, Du Cheon, Han, Mu Hyeop
• Primary Examiner(s): Wu, Jingge
• Application Number:
  US15/531,646
• Publication Number:
  US 20180206767A1
• Time in Patent Office: 865 Days
• CPC Class Codes: A61B 5/0033 Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room image data processing or generation G06T
• CPC Class Codes: A61B 5/0064 Body surface scanning
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/489 Blood vessels
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F

Abstract

Correction of a non-invasive blood glucose measurement measured from a video image. Correction includes irradiating white light on the skin, filtering the white light reflected from the skin by a first wavelength filter and a second wavelength filter, obtaining a first signal including a blood glucose signal and a pulse signal based on a video image generated by the white light filtered by the first wavelength filter, obtaining a second signal including a pulse signal based on a video image generated by the white light filtered by the second wavelength filter, obtaining a blood glucose signal by subtracting the second signal from the first signal, and calculating the amount of blood glucose in a subcutaneous blood vessel based on the obtained blood glucose signal. Moreover, fundamental blood glucose signals can be extracted in real time without collecting blood.

Claims

1. A method for correction of non-invasive blood glucose measurement, comprising:

irradiating light on the region of the skin to be measured;

obtaining a pixel video image of the region of the skin including a subcutaneous blood vessel in real time from the light reflected from the skin by using an image sensor of a camera, the camera including a first wavelength filter for selection of blood glucose information, wherein the first wavelength filter filters the scope of wavelength that comprises a blood glucose information spectrum, and including a second wavelength filter for selection of pulse information, wherein the second wavelength filter filters the scope of wavelength that corresponds to a pulse information spectrum, and wherein obtaining the pixel video image in real time comprises;

obtaining a first pixel video image in real time by passing the reflected light through the first filter; and

obtaining a second pixel video image in real time by passing the reflected light through the second filter;

identifying pixels corresponding to the subcutaneous blood vessel from the pixel video images obtained in real time, and selecting a first pixel that corresponds to a specific location on the skin from the identified pixels, and obtaining a first signal that indicates the changes in the pixel information over time in the first pixel of the first pixel video image, and obtaining a second signal that indicates the changes in the pixel information over time in the first pixel of the second pixel video image, the obtained first signal including the blood glucose information and the pulse information of a specific region of the subcutaneous blood vessel, and the obtained second signal including the pulse information of the specific region of the subcutaneous blood vessel;

obtaining a blood glucose signal, wherein a pulse signal has been corrected, in real time, by removing the second signal from the first signal; and

calculating blood flow rate by using a thickness of the blood vessel and blood flow velocity, and calculating the amount of blood glucose from the calculated blood flow rate and the blood glucose signal.

2. The method for correction of non-invasive blood glucose measurement according to claim 1, wherein:

the pixel video image includes skin environment information, and

obtaining the first signal and the second signal comprises correcting the skin environment information.

3. The method for correction of non-invasive blood glucose measurement according to claim 2, wherein:

correcting the skin environment information comprises;

selecting a second pixel, from the pixel video image obtained in real time, that corresponds to a specific location on the skin where a subcutaneous blood vessel does not pass;

obtaining a third signal that indicates the changes in the pixel information over time in the second pixel of the first pixel video image;

obtaining a fourth signal that indicates the changes in the pixel information over time in the second pixel of the second pixel video image;

obtaining the first signal wherein the skin environment information has been corrected by removing the third signal from the signal that indicates the changes in the pixel information over time in the first pixel of the first pixel video image; and

obtaining the second signal wherein the skin environment information has been corrected by removing the fourth signal from the signal that indicates the changes in the pixel information over time in the first pixel of the second pixel video image.

4. The method for correction of non-invasive blood glucose measurement according to claim 3, wherein:

the first pixel that corresponds to the region identified as the subcutaneous blood vessel and the second pixel that corresponds to the region of the skin identified as where the subcutaneous blood vessel does not pass are adjacent pixels.

5. The method for correction of non-invasive blood glucose measurement according to claim 2, wherein:

the skin environment information is information with respect to one or more of the changes in the blood flow rate, the thickness of the blood vessels, and the skin color.

6. The method for correction of non-invasive blood glucose measurement according to claim 1, wherein:

the light is white light.

7. The method for correction of non-invasive blood glucose measurement according to claim 1, wherein:

the region of the skin including the subcutaneous blood vessel is the wrist.

8. The method for correction of non-invasive blood glucose measurement according to claim 1, characterized in that:

the blood glucose signal can be measured with only one pulse, so that real time check-up of blood glucose can be possible.

9. An apparatus for correction of non-invasive blood glucose measurement, comprising:

a light source that irradiates light on the region of the skin to be measured; and

a camera including an image sensor for obtaining a pixel video image of the region of the skin including a subcutaneous blood vessel in real time from the light reflected from the skin, the camera including a first wavelength filter for selection of blood glucose information, wherein the first wavelength filter filters the scope of wavelength that comprises a blood glucose information spectrum, and including a second wavelength filter for selection of pulse information, wherein the second wavelength filter filters the scope of wavelength that corresponds to a pulse information spectrum, and the pixel video image including a first pixel video image obtained in real time by passing the reflected light through the first filter and a second pixel video image obtained in real time by passing the reflected light through the second filter; and

a server including a signal processor configured to;

identify pixels corresponding to the subcutaneous blood vessel from the pixel video images obtained in real time, select a first pixel that corresponds to a specific location on the skin from the identified pixels, obtain a first signal that indicates the changes in the pixel information over time in the first pixel of the first pixel video image, and obtain a second signal that indicates the changes in the pixel information over time in the first pixel of the second pixel video image, the obtained first signal including the blood glucose information and the pulse information of a specific region of the subcutaneous blood vessel and the obtained second signal including the pulse information of the specific region of the subcutaneous blood vessel;

obtain a blood glucose signal, wherein a pulse signal has been corrected, in real time, by removing the second signal from the first signal; and

calculate blood flow rate by using the thickness of the blood vessel and blood flow velocity, and calculate the amount of blood glucose from the calculated blood flow rate and the blood glucose signal.

10. The apparatus for correction of non-invasive blood glucose measurement according to claim 9, wherein:

the pixel video image includes skin environment information, and

the signal processor is configured to obtain the first signal and the second signal by correcting the skin environment information.

11. The apparatus for correction of non-invasive blood glucose measurement according to claim 10, wherein:

the signal processor is configured to, in order to correct the skin environment information;

select a second pixel that corresponds to a specific location on the skin where a subcutaneous blood vessel does not pass from the pixel video image obtained in real time;

obtain a third signal that indicates the changes in the pixel information over time in the second pixel of the first pixel video image;

obtain a fourth signal that indicates the changes in the pixel information over time in the second pixel of the second pixel video image;

obtain the first signal wherein the skin environment information has been corrected by removing the third signal from the signal that indicates the changes in the pixel information over time in the first pixel of the first pixel video image; and

obtain the second signal wherein the skin environment information has been corrected by removing the fourth signal from the signal that indicates the changes in the pixel information over time in the second pixel of the second pixel video image.

12. The apparatus for correction of non-invasive blood glucose measurement according to claim 9, wherein:

the server is connected to the apparatus through the communication network.