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Bupropion as a modulator of drug activity

  • US 10,251,879 B2
  • Filed: 03/22/2018
  • Issued: 04/09/2019
  • Est. Priority Date: 11/05/2013
  • Status: Active Grant
First Claim
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1. A method of enhancing dextromethorphan plasma levels in a human being, comprising co-administering a bupropion with a dextromethorphan, to the human being, for at least eight consecutive days, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein the weight ratio between the dextromethorphan and the bupropion is about 0.4 to about 0.7, and wherein, on the eighth day that the bupropion and the dextromethorphan are co-administered, the AUC0-12 of dextromethorphan is at least about 15 times the AUC0-12 of dextromethorphan that would result from administering the same amount of the dextromethorphan without the bupropion for eight consecutive days.

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