Nasal stimulation for rhinitis, nasal congestion, and ocular allergies

• US 10,252,048 B2
• Filed: 02/21/2017
• Issued: 04/09/2019
• Est. Priority Date: 02/19/2016
• Status: Active Grant

• Current Assignee: Oculeve Incorporated (Abbvie Incorporated)
• Original Assignee: Oculeve Incorporated (Abbvie Incorporated)
• Inventors: Loudin, James Donald, Hamilton, Daniel N., Franke, Manfred, Ackermann, Douglas Michael
• Primary Examiner(s): Manuel, George
• Application Number:
  US15/438,577
• Publication Number:
  US 20170239459A1
• Time in Patent Office: 777 Days
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0546 Nasal electrodes
• CPC Class Codes: A61N 1/36014 External stimulators, e.g. with patch electrodes external pacemakers A61N1/3625
• CPC Class Codes: A61N 1/36034 specified by the stimulation parameters

Abstract

Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.

Claims

1. A method for treating rhinitis, the method comprising:

advancing of a handheld nasal stimulator including a stimulator body towards a first nostril and a second nostril of a patient;

positioning, via the first nostril of the patient and as a result of the advancing, a first electrode extending from the stimulator body in contact with a nasal mucosa of a first nasal turbinate of the patient;

positioning, via the second nostril of the patient and as a result of the advancing, a second electrode extending from the stimulator body in contact with a nasal mucosa of a second nasal turbinate of the patient; and

delivering an electrical stimulus via the first electrode and the second electrode to thereby treat rhinitis in the patient.

2. The method of claim 1, wherein the electrical stimulus is delivered in response to one or more symptoms of rhinitis.

3. The method of claim 2, wherein the symptoms of rhinitis comprise one or more of itching, sneezing, congestion, runny nose, post-nasal drip, mouth breathing, coughing, fatigue, headache, anosmia, phlegm, throat irritation, periorbital puffiness, watery eyes, ear pain, and fullness sensation.

4. The method of claim 1, wherein the electrical stimulus is delivered more than once per day on a scheduled basis.

5. The method of claim 1, wherein the first electrode and the second electrode are positioned adjacent to opposing sides of a nasal septum of the patient.

6. A method of treating rhinitis, the method comprising:

advancing a handheld nasal stimulator including a stimulator body towards a nose of a subject;

positioning, as a result of the advancing, an electrode extending from the stimulator body in contact with a nasal mucosa of a nasal turbinate of the subject; and

delivering an electrical stimulus via the electrode to the nasal mucosa of the subject to thereby improve rhinitis of the subject, wherein the stimulator body of the handheld stimulator comprises a control subsystem to control the electrical stimulus.

7. The method of claim 6, wherein the electrical stimulus is delivered in response to one or more symptoms of rhinitis.

8. The method of claim 7, wherein the one or more symptoms of rhinitis comprise one or more of itching, sneezing, congestion, runny nose, post-nasal drip, mouth breathing, coughing, fatigue, headache, anosmia, phlegm, throat irritation, periorbital puffiness, watery eyes, ear pain, and fullness sensation.

9. The method of claim 6, wherein the electrical stimulus is delivered at least once daily during a treatment period.

10. The method of claim 9, wherein the electrical stimulus is delivered on a scheduled basis during the treatment period.

11. A method for treating ocular allergy, the method comprising:

advancing a stimulator body of a handheld nasal stimulator towards a first nostril and a second nostril of a patient;

positioning, via the first nostril of the patient and as a result of the advancing, a first electrode extending from the stimulator body in contact with a nasal mucosa of a first nasal turbinate of the patient;

positioning, via the second nostril of the patient and as a result of the advancing, a second electrode extending from the stimulator body in contact with a nasal mucosa of a second nasal turbinate of the patient; and

delivering an electrical stimulus the first electrode and the second electrode to thereby treat ocular allergy in the patient.

12. The method of claim 11, wherein the electrical stimulus is delivered in response to one or more symptoms of ocular allergy.

13. The method of claim 12, wherein the one or more symptoms of ocular allergy comprise one or more of swelling, puffiness, itching, tearing, and discharge.

14. The method of claim 11, wherein the electrical stimulus is delivered more than once per day on a scheduled basis.

15. The method of claim 11, wherein the first electrode and the second electrode are positioned adjacent to opposing sides of a nasal septum of the patient.

16. A method of treating ocular allergy, the method comprising:

advancing a handheld nasal stimulator including a stimulator body towards a nose of a subject;

positioning, as a result of the advancing, an electrode extending from the stimulator body in contact with a nasal mucosa of a nasal turbinate of the subject;

delivering an electrical stimulus via the electrode to the nasal mucosa of the subject to thereby improve ocular allergy of the subject, wherein the stimulator body of the handheld stimulator comprises a control subsystem to control the electrical stimulus.

17. The method of claim 16, wherein the electrical stimulus is delivered in response to one or more symptoms of ocular allergy.

18. The method of claim 17, wherein the one or more symptoms of ocular allergy comprise one or more of swelling, puffiness, itching, tearing, and discharge.