Method and device for acquiring physiological data during tissue stimulation procedure

• US 10,252,049 B2
• Filed: 06/28/2016
• Issued: 04/09/2019
• Est. Priority Date: 06/30/2009
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Parramon, Jordi, Feldman, Emanuel, Shi, Jess Weiqian
• Primary Examiner(s): Flory, Christopher A
• Application Number:
  US15/195,162
• Publication Number:
  US 20160303368A1
• Time in Patent Office: 1,015 Days
• Field of Search: 607 2, 607 72, 607116
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/3614 based on impedance measurement
• CPC Class Codes: A61N 1/36164 Sub-threshold or non-excitatory signals non-excitatory signals to the heart A61N1/3628
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer

Abstract

A method and system of providing therapy to a patient implanted with an array of electrodes is provided. A train of electrical stimulation pulses is conveyed within a stimulation timing channel between a group of the electrodes to stimulate neural tissue, thereby providing continuous therapy to the patient. Electrical parameter is sensed within a sensing timing channel using at least one of the electrodes, wherein the first stimulation timing channel and sensing timing channel are coordinated, such that the electrical parameter is sensed during the conveyance of the pulse train within time slots that do not temporally overlap any active phase of the stimulation pulses.

Claims

1. A method of providing therapy to a patient via an implanted array of electrodes, the method comprising:

delivering a first sequence of electrical stimulation pulses through a first channel to a first group of electrodes from the implanted array of electrodes to stimulate neural tissue and provide continuous therapy to the patient, the first sequence of electrical stimulation pulses having an active phase and an inactive phase; and

sensing an electrical parameter through a sensing channel using at least one sensing electrode from the first group of electrodes such that the sensing occurs during delivery of the first sequence of electrical stimulation pulses, but not during the active phase of the first sequence of electrical stimulation pulses.

2. The method of claim 1, further comprising:

delivering a second sequence of electrical stimulation pulses through a second channel to a second group of electrodes from the implanted array of electrodes to stimulate neural tissue and provide continuous therapy to the patient, the second sequence of electrical stimulation pulses having an active phase and an inactive phase; and

sensing an electrical parameter through a sensing channel using the at least one sensing electrode such that the sensing occurs during delivery of the first and second sequence of electrical stimulation pulses;

but not during the active phase of the first or second sequence of electrical stimulation pulses.

3. The method of claim 2, wherein the active phase of the first sequence of electrical stimulation pulses does not temporally overlap the active phase of the second sequence of electrical stimulation pulses.

4. The method of claim 2, further comprising storing stimulation parameters for independently programming the first and second channels.

5. The method of claim 2 further comprising delaying delivery of the active phase of the second sequence of electrical stimulation pulses until a hold-off period has elapsed following the active phase of the first sequence of electrical stimulation pulses.

6. The method of claim 1, further comprising:

transmitting sub-threshold electrical pulses through the sensing channel to a second group of electrodes; and

sensing the electrical parameter in response to the transmission of the sub-threshold electrical pulses.

7. The method of claim 1, wherein the electrical parameter includes at least one of an electrical impedance, a field potential, or an evoked action potential.

8. The method of claim 1, further comprising delaying the sensing of the electrical parameter until a hold-off period has elapsed following the active phase of the first sequence of electrical stimulation pulses.

9. The method of claim 1, further comprising wirelessly transmitting the sensed electrical parameter to an external programmer.

10. The method of claim 1 further comprising delivering a continuous train of electrical stimulation pulses through the first channel, the continuous train of electrical stimulation pulses travelling between the first group of electrodes.

11. A method of providing therapy to a patient via an implanted array of electrodes, the method comprising:

delivering a first sequence of electrical stimulation pulses through a first channel to a group of electrodes from the implanted array of electrodes to stimulate neural tissue and provide continuous therapy to the patient, the first sequence of electrical stimulation pulses having an active phase and an inactive phase; and

using arbitration to sense an electrical parameter through a sensing channel using at least one sensing electrode from the first group of electrodes, wherein the arbitration manages timing between the stimulation channel and the sensing channel such that the therapy provided by the sequence of stimulation pulses is not modified b the sensing channel by allowing the stimulation and sensing channels to have overlapping pulses only when the sensing channel is synchronized to the stimulation channel with a delay such that at least a portion of the sensing occurs during an active phase of the first sequence of electrical stimulation pulses.

12. The method of claim 11, further comprising:

delivering a second sequence of electrical stimulation pulses through a second channel to a second group of electrodes from the implanted array of electrodes to stimulate neural tissue and provide continuous therapy to the patient, the second sequence of electrical stimulation pulses having an active phase and an inactive phase; and

sensing an electrical parameter through a sensing channel using the at least one sensing electrode such that the sensing occurs during the active phase of the first or second sequence of electrical stimulation pulses.

13. The method of claim 12, wherein the active phase of the first sequence of electrical stimulation pulses does not temporally overlap the active phase of the second sequence of electrical stimulation pulses.

14. The method of claim 12, further comprising storing stimulation parameters for independently programming the first and second channels.

15. The method of claim 12 further comprising delaying delivery of the active phase of the second sequence of electrical stimulation pulses until a hold-off period has elapsed following the active phase of the first sequence of electrical stimulation pulses.

16. The method of claim 11, further comprising:

transmitting sub-threshold electrical pulses through the sensing channel to a second group of electrodes; and

sensing the electrical parameter in response to the transmission of the sub-threshold electrical pulses.

17. The method of claim 11, wherein the electrical parameter includes at least one of an electrical impedance, a field potential, or an evoked action potential.

18. The method of claim 11, further comprising wirelessly transmitting the sensed electrical parameter to an external programmer.

19. The method of claim 11 further comprising delivering a continuous train of electrical stimulation pulses through the first channel, the continuous train of electrical stimulation pulses travelling between the first group of electrodes.

20. A method of providing therapy to a patient via an implanted array of electrodes, the method comprising:

delivering a sequence of electrical stimulation pulses through a stimulation channel to a group of stimulation electrodes to stimulate neural tissue and provide continuous therapy to the patient, the sequence of electrical stimulation pulses having an active phase and an inactive phase; and

using arbitration to sense an electrical parameter through a sensing channel using at least one sensing electrode such that the sensing occurs during delivery of the sequence of electrical stimulation pulses, wherein the arbitration manages timing between the stimulation channel and the sensing channel such that the therapy provided by the sequence of stimulation pulses is not modified by the sensing channel either by;

preventing the stimulation and sensing channels from having overlapping pulses, or

allowing the stimulation and sensing channels to have overlapping pulses only when the sensing channel is synchronized to the stimulation channel with a delay.