Methods relating to the use of remote ischemic conditioning

• US 10,252,052 B2
• Filed: 03/14/2014
• Issued: 04/09/2019
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Hospital For SICK Children
• Original Assignee: Hospital For SICK Children
• Inventors: Redington, Andrew
• Primary Examiner(s): Szpira, Julie A
• Application Number:
  US14/773,905
• Publication Number:
  US 20160038737A1
• Time in Patent Office: 1,852 Days
• CPC Class Codes: A61B 17/135 inflatable for measuring blood pressure A61B5/022; inflatable pressure pads A61F5/34
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/36034 specified by the stimulation parameters

Abstract

The invention contemplates, inter alia, the use of remote ischemic conditioning in the treatment of a variety of disorders.

Claims

1. A method comprising

performing remote ischemic conditioning (RIC) on a limb of a subject having cancer to treat the cancer,

wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more and wherein a second or subsequent cycle begins upon conclusion of reperfusion of a previous cycle.

2. The method of claim 1, wherein the subject is receiving a second therapy.

3. The method of claim 2, wherein the second therapy is administered at less than a maximum tolerable dose.

4. The method of claim 2, wherein the second therapy is administered at greater than the maximum tolerable dose.

5. The method of claim 2, wherein the second therapy is antibody-based therapy.

6. The method of claim 2, wherein one or more RIC regimens is performed within 48 hours, within 24 hours, within 12 hours, within 6 hours, within 4 hours, within 2 hours, within 1 hour or within 30 minutes of the administration of the second therapy.

7. The method of claim 1, wherein the cancer is not associated with an ischemia/reperfusion injury.

8. A method comprising

performing remote ischemic conditioning (RIC) on a subject having an infectious disease to treat the infectious disease,

wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more and wherein a second or subsequent cycle begins upon conclusion of reperfusion of a previous cycle.

9. The method of claim 8, wherein the infectious disease is bacterial meningitis.

10. The method of claim 8, wherein the infectious disease is not associated with an ischemia/reperfusion injury.

11. A method comprising

performing remote ischemic conditioning (RIC) on a subject having a lysosomal storage disorder to treat the lysosomal storage disorder,

wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more and wherein a second or subsequent cycle begins upon conclusion of reperfusion of a previous cycle.

12. The method of claim 11, wherein the lysosomal storage disorder is GM1 gangliosidosis or Tay-Sachs disease.

13. The method of claim 11, wherein the subject is receiving a second therapy that is enzyme replacement therapy.

14. The method of claim 13, wherein one or more RIC regimens is performed within 48 hours, within 24 hours, within 12 hours, within 6 hours, within 4 hours, within 2 hours, within 1 hour or within 30 minutes of the administration of the enzyme replacement therapy.

15. The method of claim 11, wherein the lysosomeal storage disorder is not associated with an ischemia/reperfusion injury.

16. A method comprising

performing remote ischemic conditioning (RIC) on a subject having kidney disease that is not associated with ischemia/reperfusion injury, to treat the kidney disease,

wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more and wherein a second or subsequent cycle begins upon conclusion of reperfusion of a previous cycle.

17. A method comprising

performing remote ischemic conditioning (RIC) on a subject having transplant rejection that is not associated with ischemia/reperfusion injury, to reduce or alleviate the transplant rejection,

wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more and wherein the second or subsequent cycle begins upon conclusion of reperfusion of a previous cycle.

18. A method comprising

performing remote ischemic conditioning (RIC) on a subject having cancer to treat the cancer,

wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more, wherein a second or subsequent cycle begins upon the conclusion of reperfusion of a previous cycle, and

wherein the subject is receiving a second therapy which is an antibody-based therapy.

19. The method of claim 18, wherein one or more RIC regimens is performed within 48 hours, within 24 hours, within 12 hours, within 6 hours, within 4 hours, within 2 hours, within 1 hour or within 30 minutes of the administration of the antibody-based therapy.