Method and apparatus for preventing or terminating epileptic seizures

• US 10,252,056 B2
• Filed: 11/18/2016
• Issued: 04/09/2019
• Est. Priority Date: 11/18/2015
• Status: Active Grant

• Current Assignee: David J. Mogul
• Original Assignee: David J. Mogul
• Inventors: Mogul, David J.
• Primary Examiner(s): Fairchild, Mallika D
• Application Number:
  US15/355,344
• Publication Number:
  US 20170136240A1
• Time in Patent Office: 872 Days
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36171 Frequency

Abstract

A method and apparatus for preventing or terminating seizures, by stimulating a brain with at least two implanted electrodes, each implanted in a different one of at least two regions of the brain, with a frequency to emulate and/or disrupt neuronal synchrony. Upon detecting a potential or actual seizure occurrence, the frequency is electrically applied to the brain upon the detection to preempt or terminate the potential or actual seizure occurrence.

Claims

1. A method of preventing or terminating seizures, comprising:

determining neuronal synchrony between at least two sites of a brain of a patient;

stimulating the brain with at least two implanted electrodes, each implanted in a different one of at least two regions of the brain, with a frequency to emulate or disrupt the neuronal synchrony, wherein the frequency comprises a predetermined seizure termination frequency determined from seizure frequencies measured across a seizure occurrence in the at least two regions of the brain.

2. The method of claim 1, wherein the stimulation comprises deep brain stimulation before or during a seizure.

3. The method of claim 1, wherein the frequency is synchronized to a predetermined seizure termination frequency of the at least two regions of the brain.

4. The method of claim 3, further comprising detecting a potential or actual seizure occurrence via the neuronal synchrony, wherein the frequency is electrically applied to the brain upon the detection of the potential or actual seizure occurrence.

5. The method of claim 1, wherein the frequency disrupts an evolving synchronization between structures in the at least two regions of the brain to preempt or terminate a seizure.

6. The method of claim 1, wherein the predetermined seizure termination frequency is obtained from electrophysiological dynamics of the brain measured at or near an end of a seizure within the brain.

7. The method of claim 6, wherein the electrophysiological dynamics comprise a termination frequency that is synchronized between the at least two regions of the brain at or near the end of the seizure within the brain.

8. The method of claim 1, wherein the electrodes are actuated by an implanted neurostimulator including a power source.

9. The method of claim 8, wherein the neurostimulator comprises a stimulation generator protocol on a non-transitory recordable medium and executable to stimulate the at least two regions of the brain with the frequency synchronized to the predetermined seizure termination frequency.

10. A non-transitory computer readable storage medium storing code executable on an implantable neurostimulator to perform the method according to claim 1.

11. The method of claim 1, further comprising determining the neuronal synchrony between more than two sites of the brain.

12. A method of preventing or terminating seizures, comprising:

determining a neuronal synchrony frequency between at least two regions of a brain; and

stimulating the brain with at least two implanted electrodes, each implanted in a different one of the at least two regions of the brain, to emulate or disrupt the neuronal synchrony by electrically applying the frequency to the brain upon the determining of the neuronal synchrony.

13. The method of claim 12, wherein the frequency comprises a predetermined seizure termination frequency determined from seizure frequencies measured across a seizure occurrence in the at least two regions of the brain.

14. An apparatus for preventing or terminating seizures, comprising:

a neurostimulator including a stimulation generator and a power supply connected to the stimulation generator, wherein the stimulation generator generates electrical stimulation for and through at least two electrodes implantable within a brain; and

a control protocol on a non-transitory recordable medium in executable combination with the stimulation generator and adapted to stimulate at least two regions of the brain with a frequency to emulate or disrupt neuronal synchrony, wherein the frequency disrupts an evolving synchronization between structures in the at least two regions of the brain to preempt or terminate a seizure, and the frequency comprises a predetermined seizure termination frequency predetermined from seizure frequencies measured across a seizure occurrence in the at least two regions of the brain.

15. The apparatus of claim 14, wherein the frequency is synchronized to a predetermined seizure termination frequency of the at least two regions of the brain.

16. The apparatus of claim 15, wherein the predetermined seizure termination frequency is determined by the neuro stimulator and electrodes.

17. The apparatus of claim 14, wherein the predetermined seizure termination frequency is obtained from electrophysiological dynamics of the brain measured at or near an end of a seizure within the brain.

18. An apparatus for preventing or terminating seizures, comprising:

a neurostimulator including a stimulation generator and a power supply connected to the stimulation generator, wherein the stimulation generator generates electrical stimulation for and through at least two electrodes implantable within a brain;

a control protocol on a non-transitory recordable medium in executable combination with the stimulation generator and adapted to stimulate at least two regions of the brain with a frequency to emulate or disrupt neuronal synchrony, wherein the frequency disrupts an evolving synchronization between structures in the at least two regions of the brain to preempt or terminate a seizure; and

a detector adapted to determine the neuronal synchrony, wherein the frequency is electrically applied to the brain upon the determination of the neuronal synchrony.

19. The apparatus of claim 18, wherein the detector determines a potential or actual seizure occurrence, and the frequency is electrically applied to the brain upon the detection of the potential or actual seizure occurrence.

20. The apparatus of claim 18, wherein the frequency comprises a predetermined seizure termination frequency predetermined from seizure frequencies measured across a seizure occurrence in the at least two regions of the brain.