Ophthalmic phototherapy method

• US 10,252,078 B2
• Filed: 04/19/2018
• Issued: 04/09/2019
• Est. Priority Date: 04/14/2005
• Status: Active Grant

• Current Assignee: Photospectra Health Sciences, Inc.
• Original Assignee: Photospectra Health Sciences, Inc.
• Inventors: Dotson, Robert S.
• Primary Examiner(s): Downey, John R
• Application Number:
  US15/957,496
• Publication Number:
  US 20180236258A1
• Time in Patent Office: 355 Days
• Field of Search: 606 4- 6
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: A61B 3/12 for looking at the eye fundus, e.g. ophthalmoscopes A61B3/13 takes precedence
• CPC Class Codes: A61B 3/1241 specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
• CPC Class Codes: A61B 3/14 Arrangements specially adapted for eye photography apparatus or arrangements for taking photographs per se G03B
• CPC Class Codes: A61F 2009/00868 Ciliary muscles or trabecular meshwork
• CPC Class Codes: A61F 2009/00872 Cornea
• CPC Class Codes: A61F 2009/00891 Glaucoma
• CPC Class Codes: A61F 9/0079 using non-laser electromagnetic radiation, e.g. non-coherent light or microwaves
• CPC Class Codes: A61N 2005/0626 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 2005/0644 Handheld applicators
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 2005/0663 Coloured light
• CPC Class Codes: A61N 5/0613 Apparatus adapted for a specific treatment
• CPC Class Codes: A61N 5/067 using laser light

Abstract

Provided herein are ophthalmic phototherapy devices and associated phototherapy methods for promoting healing of damaged or diseased eye tissue. An ophthalmic phototherapy device includes a light emitting mechanism for transmitting light of at least one preselected wavelength to the eye tissue. An ophthalmic phototherapy method includes directing light of at least one wavelength for a selected period of time to a portion of damaged or diseased eye tissue, whereby the light transmitted to the damaged or diseased eye tissue stimulates cellular activity in the eye tissue to promote healing.

Claims

1. A method for treating glaucoma in an eye of a patient, the method comprising:

during a treatment session with a phototherapy device having one or more arrays of LED(s), low power laser source(s), or any combination thereof, directing, to the eye of the patient having glaucoma, a first light of at least a first wavelength for a first preselected period of time, a second light of at least a second wavelength for a second preselected period of time, and a third light of at least a third wavelength for a third preselected period of time, thereby exposing at least a portion of the eye tissue in the eye of the patient to the directed first light, the directed second light, and the directed third light, wherein;

(i) each of the directed first light, the directed second light, and the directed third light independently has a preselected brightness;

(ii) one of the first wavelength, the second wavelength, and the third wavelength corresponds to near infra-red light;

(iii) another of the first wavelength, the second wavelength, and the third wavelength corresponds to yellow light; and

(iv) yet another of the first wavelength, the second wavelength, and the third wavelength corresponds to red light.

2. The method of claim 1, wherein the wavelength corresponding to yellow light is approximately 577 nm to 597 nm.

3. The method of claim 2, wherein the wavelength corresponding to yellow light is approximately 590 nm.

4. The method of claim 1, wherein the wavelength corresponding to red light is approximately 640 nm to 700 nm.

5. The method of claim 4, wherein the wavelength corresponding to red light is approximately 670 nm.

6. The method of claim 1, wherein the wavelength corresponding to near infra-red light is approximately 810 nm.

7. The method of claim 1, wherein the wavelength corresponding to yellow light is approximately 590 nm and the wavelength corresponding to red light is approximately 670 nm.

8. The method of claim 1, wherein the wavelength corresponding to yellow light is approximately 590 nm and the wavelength corresponding to near infra-red light is approximately 810 nm.

9. The method of claim 1, wherein the wavelength corresponding to red light is approximately 670 nm and the wavelength corresponding to near infra-red light is approximately 810 nm.

10. The method of claim 1, wherein the wavelength corresponding to yellow light is approximately 590 nm, the wavelength corresponding to red light is approximately 670 nm, and the wavelength corresponding to near infra-red light is approximately 810 nm.

11. The method of claim 1, wherein two or more of the directed first light, the directed second light, and the directed third light are directed to the eye of the patient in a sequence.

12. The method of claim 1, wherein one or more of the directed first light, the directed second light, and the directed third light comprises a continuous beam of light.

13. The method of claim 1, wherein one or more of the directed first light, the directed second light, and third directed light comprises a pulsed beam of light.

14. The method of claim 1, wherein one or more of the directed first light, the directed second light, and the directed third light comprises a pulsed beam of light, and a different one or more of the directed first light, the directed second light, and the directed third light comprises a continuous beam of light, wherein the pulsed beam of light and the continuous beam of light are directed to the eye of the patient in a sequential combination.

15. The method of claim 1, wherein two or three of the directed first light, the directed second light, and directed third light are directed to the eye of the patient simultaneously.

16. The method of claim 15, wherein the two or three of the directed first light, the directed second light, and directed third light that are directed to the eye of the patient simultaneously are directed for a same preselected period of time.

17. The method of claim 1, wherein the first preselected period of time, the second preselected period of time, and the third preselected period of time are different.

18. The method of claim 1, wherein two or three of the first preselected period of time, the second preselected period of time, and the third preselected period of time are the same.

19. The method of claim 1, wherein the treatment session comprises directing a dose of light that includes the directed first light, the directed second light, and the directed third light, to the eye of the patient, wherein the dose of light comprises a light energy of approximately 4 joules/cm², or less.

20. The method of claim 19, wherein the dose of light is directed to the eye of the patient over a time period of less than one minute to approximately 10 minutes.

21. The method of claim 1, wherein the treatment session comprises directing a dose of light that includes the directed first light, the directed second light, and the directed third light to the eye of the patient, wherein the dose of light comprises a light energy greater than 4 joules/cm².