Functionalized Exendin-4 derivatives
First Claim
Patent Images
1. A method of treating type 2 diabetes, treating obesity, decreasing food intake, increasing energy expenditure, reducing body weight, delaying progression from impaired glucose tolerance (IGT) to type 2 diabetes, delaying progression from type 2 diabetes to insulin-requiring diabetes, regulating appetite, or inducing satiety, in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of a peptidic compound having formula (I):
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R1—
Z—
R2
(I),or a salt or solvate thereof, or a pharmaceutical composition comprising a compound of formula (I) or salt or solvate thereof as an active agent together with at least one pharmaceutically acceptable carrier,wherein Z is a peptide moiety having the formula (II);
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Abstract
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
638 Citations
30 Claims
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1. A method of treating type 2 diabetes, treating obesity, decreasing food intake, increasing energy expenditure, reducing body weight, delaying progression from impaired glucose tolerance (IGT) to type 2 diabetes, delaying progression from type 2 diabetes to insulin-requiring diabetes, regulating appetite, or inducing satiety, in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of a peptidic compound having formula (I):
-
R1—
Z—
R2
(I),or a salt or solvate thereof, or a pharmaceutical composition comprising a compound of formula (I) or salt or solvate thereof as an active agent together with at least one pharmaceutically acceptable carrier, wherein Z is a peptide moiety having the formula (II); - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method of treating type 2 diabetes, treating obesity, decreasing food intake, increasing energy expenditure, reducing body weight, delaying progression from impaired glucose tolerance (IGT) to type 2 diabetes, delaying progression from type 2 diabetes to insulin-requiring diabetes, regulating appetite, or inducing satiety, in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of a peptidic compound of the amino acid sequence of
SEQ ID NO: - 9 or a salt or solvate thereof,
SEQ ID NO;
12 or a salt or solvate thereof,SEQ ID NO;
14 or a salt or solvate thereof,SEQ ID NO;
16 or a salt or solvate thereof,SEQ ID NO;
17 or a salt or solvate thereof,SEQ ID NO;
18 or a salt or solvate thereof,SEQ ID NO;
20 or a salt or solvate thereof, orSEQ ID NO;
21 or a salt or solvate thereof.
- 9 or a salt or solvate thereof,
Specification