Biosensors for biological or chemical analysis and methods of manufacturing the same
First Claim
1. A biosensor comprising:
- a flow cell; and
a detection device having the flow cell coupled thereto, the flow cell and the detection device forming a flow channel that is configured to have biological or chemical substances therein that generate light emissions in response to an excitation light, the detection device including;
a device base having a sensor array of light sensors and a guide array of light guides, the light guides having input regions that are configured to receive the excitation light and the light emissions from the flow channel, the light guides extending into the device base from the input regions toward corresponding light sensors and having a filter material that is configured to filter the excitation light and permit the light emissions to propagate toward the corresponding light sensors, the device base including device circuitry electrically coupled to the light sensors and configured to transmit data signals based on photons detected by the light sensors; and
a shield layer extending between the flow channel and the device base, the shield layer having apertures that are positioned relative to the input regions of corresponding light guides such that the light emissions propagate through the apertures into the corresponding input regions, the shield layer extending between adjacent apertures and configured to block the excitation light and the light emissions incident on the shield layer between the adjacent apertures.
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Accused Products
Abstract
Biosensor including a device base having a sensor array of light sensors and a guide array of light guides. The light guides have input regions that are configured to receive excitation light and light emissions generated by biological or chemical substances. The light guides extend into the device base toward corresponding light sensors and have a filter material. The device base includes device circuitry electrically coupled to the light sensors and configured to transmit data signals. The biosensor also includes a shield layer having apertures that are positioned relative to the input regions of corresponding light guides such that the light emissions propagate through the apertures into the corresponding input regions. The shield layer extends between adjacent apertures and is configured to block the excitation light and the light emissions incident on the shield layer between the adjacent apertures.
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Citations
13 Claims
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1. A biosensor comprising:
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a flow cell; and a detection device having the flow cell coupled thereto, the flow cell and the detection device forming a flow channel that is configured to have biological or chemical substances therein that generate light emissions in response to an excitation light, the detection device including; a device base having a sensor array of light sensors and a guide array of light guides, the light guides having input regions that are configured to receive the excitation light and the light emissions from the flow channel, the light guides extending into the device base from the input regions toward corresponding light sensors and having a filter material that is configured to filter the excitation light and permit the light emissions to propagate toward the corresponding light sensors, the device base including device circuitry electrically coupled to the light sensors and configured to transmit data signals based on photons detected by the light sensors; and a shield layer extending between the flow channel and the device base, the shield layer having apertures that are positioned relative to the input regions of corresponding light guides such that the light emissions propagate through the apertures into the corresponding input regions, the shield layer extending between adjacent apertures and configured to block the excitation light and the light emissions incident on the shield layer between the adjacent apertures. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13)
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9. A method of manufacturing a biosensor, the method comprising:
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providing a device base having a sensor array of light sensors and device circuitry that is electrically coupled to the light sensors and configured to transmit data signals based on photons detected by the light sensors, the device base having an outer surface; applying a shield layer to the outer surface of the device base; forming apertures through the shield layer; forming guide cavities that extend from corresponding apertures toward a corresponding light sensor of the sensor array; depositing filter material within the guide cavities, wherein a portion of the filter material extends along the shield layer; curing the filter material; removing the filter material from the shield layer, the filter material within the guide cavities forming light guides; and applying a passivation layer to the shield layer such that the passivation layer extends directly along the shield layer and across the apertures.
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Specification