Automatic isothermal titration microcalorimeter apparatus and method of use
DC CAFCFirst Claim
1. An automated isothermal titration micro calorimetry (ITC) system, comprising:
- a controller configured to control automated operation of the ITC system;
a microcalorimeter comprising a sample cell and a reference cell, the sample cell being accessible via a sample cell stem and the reference cell being accessible via a reference cell stem;
a pipette assembly comprising a titration needle configured to be inserted into the sample cell and supply titrant to the sample cell;
a rotatable pipette translation unit comprising a rotatable pipette arm configured to support the pipette assembly and place the pipette assembly in a titration position and in a washing position, wherein the rotatable pipette arm is configured to be moved vertically along an axis and the titration needle is vertically moveable in the direction of the axis for insertion into the sample cell; and
a rotatable cell preparation unit comprising a rotatable cell arm configured to wash the sample cell and replace sample liquid in the sample cell,wherein the controller is configured to control operation of the ITC system to wash the titration needle of the pipette assembly, wash the sample cell, and fill the sample cell with sample liquid.
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Abstract
Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.
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Citations
30 Claims
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1. An automated isothermal titration micro calorimetry (ITC) system, comprising:
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a controller configured to control automated operation of the ITC system; a microcalorimeter comprising a sample cell and a reference cell, the sample cell being accessible via a sample cell stem and the reference cell being accessible via a reference cell stem; a pipette assembly comprising a titration needle configured to be inserted into the sample cell and supply titrant to the sample cell; a rotatable pipette translation unit comprising a rotatable pipette arm configured to support the pipette assembly and place the pipette assembly in a titration position and in a washing position, wherein the rotatable pipette arm is configured to be moved vertically along an axis and the titration needle is vertically moveable in the direction of the axis for insertion into the sample cell; and a rotatable cell preparation unit comprising a rotatable cell arm configured to wash the sample cell and replace sample liquid in the sample cell, wherein the controller is configured to control operation of the ITC system to wash the titration needle of the pipette assembly, wash the sample cell, and fill the sample cell with sample liquid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An isothermal titration micro calorimetry (ITC) system, comprising:
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a microcalorimeter comprising a sample cell and a reference cell; a pipette assembly comprising a titration needle configured to be inserted into the sample cell and supply titrant to the sample cell; a rotation pipette translation unit configured to place the pipette assembly in a titration position and in a washing position, wherein the rotatable pipette translation unit comprises a rotatable pipette arm that is configured to be moved vertically along an axis and the titration needle is vertically moveable in the direction of the axis for insertion into the sample cell; and a rotatable cell preparation unit configured to wash the sample cell when the pipette assembly is placed in another position than the position for titration. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification