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Automatic isothermal titration microcalorimeter apparatus and method of use

DC CAFC
  • US 10,254,239 B2
  • Filed: 06/28/2018
  • Issued: 04/09/2019
  • Est. Priority Date: 12/02/2008
  • Status: Active Grant
First Claim
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1. An automated isothermal titration micro calorimetry (ITC) system, comprising:

  • a controller configured to control automated operation of the ITC system;

    a microcalorimeter comprising a sample cell and a reference cell, the sample cell being accessible via a sample cell stem and the reference cell being accessible via a reference cell stem;

    a pipette assembly comprising a titration needle configured to be inserted into the sample cell and supply titrant to the sample cell;

    a rotatable pipette translation unit comprising a rotatable pipette arm configured to support the pipette assembly and place the pipette assembly in a titration position and in a washing position, wherein the rotatable pipette arm is configured to be moved vertically along an axis and the titration needle is vertically moveable in the direction of the axis for insertion into the sample cell; and

    a rotatable cell preparation unit comprising a rotatable cell arm configured to wash the sample cell and replace sample liquid in the sample cell,wherein the controller is configured to control operation of the ITC system to wash the titration needle of the pipette assembly, wash the sample cell, and fill the sample cell with sample liquid.

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