Near-infrared optical imaging system for hemodynamic imaging, pulse monitoring, and mapping spatio-temporal features
First Claim
1. A system comprising:
- a hand-held probe assembly comprising;
a probe body;
a detector assembly comprising a detector configured to capture an area of an image in the near-infrared spectrum; and
a source assembly comprising a near infrared light source movable relative to the detector and configured to obtain both reflectance and trans-illumination measurements depending upon the position of the near infrared light source relative to the detector; and
a control module configured to capture dynamic near-infrared signals at a plurality of wavelengths and to obtain real-time dynamic hemodynamic signals.
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Abstract
The present application describes techniques to image biological tissue to determine biological information of an imaged tissue sample such as changes in hemoglobin concentrations, blood flow rate (pulse), and/or spatio-temporal features. Embodiments include illuminating the tissue sample with light in the near-infrared (NIR) spectrum, which is minimally absorbed but scattered through the tissue sample. By detecting the NIR light that is attenuated through, transmitted through, and/or reflected off the tissue to be imaged, the resulting NIR intensity signals may be further analyzed to provide this data. Embodiments include using multiple NIR light sources having varying wavelengths to obtain changes in the oxy- and deoxy-hemoglobin concentrations of the imaged tissue region. The tissue sample may be imaged over a time period, and the NIR images may be viewed statically or in real time after post-processing analyses have been performed.
33 Citations
37 Claims
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1. A system comprising:
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a hand-held probe assembly comprising; a probe body; a detector assembly comprising a detector configured to capture an area of an image in the near-infrared spectrum; and a source assembly comprising a near infrared light source movable relative to the detector and configured to obtain both reflectance and trans-illumination measurements depending upon the position of the near infrared light source relative to the detector; and a control module configured to capture dynamic near-infrared signals at a plurality of wavelengths and to obtain real-time dynamic hemodynamic signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A computer-implemented method, comprising:
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capturing, via a detector assembly including a detector, an area of an image in the near-infrared spectrum; obtaining, via a source assembly that includes a near infrared light source movable relative to the detector, both (i) reflectance, and (ii) trans-illumination measurements depending upon a position of the near infrared light source relative to the detector; and capturing, via a control module, dynamic near-infrared signals at a plurality of wavelengths to obtain real-time dynamic hemodynamic signals. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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Specification