Electrical ablation devices and methods
First Claim
1. A computer-implemented system for delivering energy to tissue having a necrotic threshold, the computer-implemented system comprising:
- an electrode array comprising a plurality of electrodes;
a central electrode positioned intermediate the plurality of electrodes;
a ground pad adjacent the tissue;
a processor; and
a memory coupled to the processor and storing instructions to be executed by the processor to;
apply a first sequence of electrical pulses to the electrode array less than the necrotic threshold to induce thermal heating in the tissue;
apply a second sequence of electrical pulses to the central electrode equal to or greater than the necrotic threshold to induce cell necrosis in the tissue by irreversible electroporation; and
apply a ground potential to the ground pad.
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Accused Products
Abstract
A computer-implemented system for delivering energy to tissue having a necrotic threshold may generally comprise an electrode array comprising a plurality of electrodes, a central electrode positioned intermediate the plurality of electrodes, and a controller configured to not only apply a first sequence of electrical pulses to the electrode array to induce thermal heating in the tissue and reduce the necrotic threshold of the tissue but also apply a second sequence of electrical pulses to the central electrode to induce cell necrosis in the tissue by irreversible electroporation. Electrical ablation devices and methods of using the same are also described herein.
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Citations
20 Claims
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1. A computer-implemented system for delivering energy to tissue having a necrotic threshold, the computer-implemented system comprising:
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an electrode array comprising a plurality of electrodes; a central electrode positioned intermediate the plurality of electrodes; a ground pad adjacent the tissue; a processor; and a memory coupled to the processor and storing instructions to be executed by the processor to; apply a first sequence of electrical pulses to the electrode array less than the necrotic threshold to induce thermal heating in the tissue; apply a second sequence of electrical pulses to the central electrode equal to or greater than the necrotic threshold to induce cell necrosis in the tissue by irreversible electroporation; and apply a ground potential to the ground pad. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A computer-implemented system for delivering energy to tissue having a necrotic threshold, the system comprising:
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an electrode arrangement comprising a plurality of outer electrodes; an inner electrode surrounded by the plurality of outer electrodes; a processor; and a memory coupled to the processor and storing instructions to be executed by the processor to; apply a first sequence of electrical pulses to the plurality of outer electrodes to induce thermal heating in the tissue without inducing irreversible electroporation in the tissue; and apply a second sequence of electrical pulses to the inner electrode to induce cell necrosis in the tissue by irreversible electroporation. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A computer-implemented system for delivering energy to tissue having a necrotic threshold, the system comprising:
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an electrode array comprising a plurality of electrodes; a central electrode positioned intermediate the plurality of electrodes; and a controller configured to; apply a first sequence of electrical pulses to the electrode array to induce thermal heating in the tissue and reduce the necrotic threshold of the tissue; and apply a second sequence of electrical pulses to the central electrode to induce cell necrosis in the tissue by irreversible electroporation. - View Dependent Claims (19, 20)
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Specification