Devices and methods for left atrial appendage closure

• US 10,258,408 B2
• Filed: 10/31/2014
• Issued: 04/16/2019
• Est. Priority Date: 10/31/2013
• Status: Active Grant

• Current Assignee: SentreHeart, LLC (Atricure, Inc.)
• Original Assignee: SentreHEART Incorporated (Atricure, Inc.)
• Inventors: Fung, Gregory W., Lee, Randall J., Pong, Russell, Clark, III, Robert L., Escano, Arnold M.
• Primary Examiner(s): Johnson, Nicole F
• Application Number:
  US14/530,575
• Publication Number:
  US 20150119884A1
• Time in Patent Office: 1,628 Days
• Field of Search: 606 21
• CPC Class Codes: A61B 17/12013 for use in minimally invasive surgery, e.g. endoscopic surgery
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/00477 Coupling A61B2017/0046 takes precedence
• CPC Class Codes: A61B 2017/00876 magnetic
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/00357 Endocardium
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/141 Snare
• CPC Class Codes: A61B 2018/142 at least partly surrounding the target, e.g. concave, curved or in the form of a cave

Abstract

Described here are devices, systems, and methods for closing the left atrial appendage. The methods described here utilize a closure device for closing the left atrial appendage and guides or expandable elements with ablation or abrading elements to ablate or abrade the left atrial appendage. In general, these methods include positioning a balloon at least partially within the atrial appendage, positioning a closure assembly of a closure device around an exterior of the atrial appendage, inflating the balloon, partially closing the closure assembly, ablating the interior tissue of the atrial appendage with the inflated balloon, removing the balloon from the atrial appendage, and closing the atrial appendage with the closure assembly.

Claims

1. A method of closing a left atrial appendage comprising:

advancing a snare loop assembly to the left atrial appendage, the snare loop assembly comprising a snare loop and suture loop releasably coupled to the snare loop;

partially closing the snare loop assembly around the left atrial appendage;

ablating the left atrial appendage for a first period of time after partially closing the snare loop assembly;

further closing the snare loop assembly around the left atrial appendage to close the left atrial appendage;

ablating the left atrial appendage for a second period of time after further closing the snare loop assembly; and

releasing the suture loop from the snare loop assembly.

2. The method of claim 1, wherein ablating the left atrial appendage for a first period of time comprises ablating an internal surface of the left atrial appendage.

3. The method of claim 1, wherein ablating the left atrial appendage for a second period of time comprises ablating an external surface of the left atrial appendage.

4. The method of claim 1, wherein ablating the left atrial appendage for a second period of time comprises ablating the left atrial appendage with the snare loop.

5. The method of claim 4, wherein the snare loop comprises an electrically conductive portion and an insulated portion.

6. The method of claim 4, wherein the snare loop assembly comprises an electrode positioned on a portion of the snare loop.

7. The method of claim 1, wherein the left atrial appendage is ablated during both the first time period and the second time period using RF energy.

8. The method of claim 1 further comprising positioning a distal portion of a first guide element in a pericardial space.

9. The method of claim 8, wherein advancing the snare loop assembly comprises advancing the snare loop assembly along the first guide element.

10. The method of claim 8 further comprising positioning a distal portion of a second guide element in the left atrial appendage.

11. The method of claim 10, wherein the first guide element comprises a first magnet and the second guide element comprises a second magnet and the method further comprises aligning the first and second guide elements across the left atrial appendage using the first and second magnets.

12. A method of ablating a left atrial appendage comprising:

advancing a snare loop assembly around the left atrial appendage, the snare loop assembly comprising an ablation loop and a suture loop releasably coupled thereto;

closing the snare loop assembly around the left atrial appendage;

ablating the left atrial appendage with the ablation loop for a first period of time;

adjusting at least a portion of the snare loop assembly around the left atrial appendage; and

ablating the left atrial appendage with the ablation loop for a second period of time after adjusting at least a portion of the snare loop assembly.

13. The method of claim 12, wherein the snare loop assembly is advanced around the left atrial appendage from a sub-xiphoid approach.

14. The method of claim 12, wherein the snare loop assembly further comprises a retention member releasably coupling the suture loop to the ablation loop.

15. The method of claim 12 further comprising releasing the suture loop from the snare loop assembly.

16. The method of claim 12, wherein the left atrial appendage is ablated during both the first time period and the second time period using RF energy.

17. The method of claim 12, wherein the left atrial appendage is ablated during both the first time period and the second time period using cryogenic fluid.

18. The method of claim 12 further comprising positioning a distal portion of a first guide element in a pericardial space.

19. The method of claim 18, wherein advancing the snare loop assembly comprises advancing the snare loop assembly along the first guide element.

20. The method of claim 18 further comprising positioning a distal portion of a second guide element in the left atrial appendage.

21. The method of claim 20, wherein the first guide element comprises a first magnet and the second guide element comprises a second magnet and the method further comprises aligning the first and second guide elements across the left atrial appendage using the first and second magnets.