Compositions and methods to affect skin irritation

• US 10,258,643 B2
• Filed: 06/12/2017
• Issued: 04/16/2019
• Est. Priority Date: 12/28/2015
• Status: Active Grant

• Current Assignee: Alumend LLC, WavePharma LLC
• Original Assignee: Alumend LLC, WavePharma LLC
• Inventors: Utecht, Ronald E., Downey, Therese M., Seiberg, Miri, Shapiro, Stanley S., Foster, Jack V.
• Primary Examiner(s): Song, Jianfeng
• Application Number:
  US15/619,958
• Publication Number:
  US 20170274009A1
• Time in Patent Office: 673 Days
• CPC Class Codes: A61F 13/8405 Additives, e.g. for odour, disinfectant or pH control
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 2800/782 Enzyme inhibitors; Enzyme antagonists
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/185 Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids hydroxamic acids A61K31/16; peroxy acids A61K31/327
• CPC Class Codes: A61K 31/203 Retinoic acids ; Salts thereof
• CPC Class Codes: A61K 31/722 Chitin, chitosan
• CPC Class Codes: A61K 31/737 Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate A61K31/727 takes precedence
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 8/736 Chitin; Chitosan; Derivatives thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/18 Antioxidants, e.g. antiradicals preparations for protection against sunlight A61Q17/00
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Compositions are described that contain treated chitosan, modified chitosan and/or modified and treated chitosan for use in formulations for skin, hair and nails, and in compositions and methods of reducing topical agent-induced skin irritation and inflammation.

Claims

1. A method for reducing skin irritation and/or reducing skin inflammation and/or reducing irritant-induced IL-1α

secretion induced by a topical agent comprising topically applying a composition comprising;

(a) an amount of at least one topical irritating agent that causes skin irritation and/or skin inflammation and/or IL-1α

secretion, wherein the at least one topical irritating agent comprises a retinoid, a retinoid derivative, or a retinoid precursor, wherein the retinoid, retinoid derivative and the retinoid precursor are selected from the group consisting of retinol, retinal, retinyl esters, tretinoin, retinoic acid, Vitamin A, an ester of Vitamin A, isotretinoin, alitertinoin, etretinate, acitretin, adapalene, bexarotene, and tazarotene, and combinations thereof; and

(b) an amount of at least one chitosan covalently modified with octane sulfonic acid via a sulfonamide linkage.

2. The method of claim 1, wherein the retinoid, retinoid derivative, or retinoid precursor comprises about 0.001-5% W/V of the total weight of the composition.

3. The method of claim 1, wherein said at least one chitosan covalently modified with octane sulfonic acid via a sulfonamide linkage comprises about 0.0001-5% W/V of the total weight of the composition.

4. The method of claim 1, wherein the at least one topical irritating agent is retinol.

5. The method of claim 1, wherein the ester of Vitamin A is retinol palmitate.

6. The method of claim 1, wherein the composition is applied to skin.

7. The method of claim 1, wherein the composition is topically applied to a human.