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Continuous cell programming devices

  • US 10,258,677 B2
  • Filed: 04/21/2016
  • Issued: 04/16/2019
  • Est. Priority Date: 02/13/2008
  • Status: Active Grant
First Claim
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1. A device comprisinga scaffold polymer selected from the group consisting of poly-lactide-co-glycolide (PLG), alginate, xanthan gum, gellan, or emulsan;

  • a tumor antigen;

    a recruitment composition comprising a cytokine, which comprises a granulocyte macrophage colony stimulating factor (GM-CSF), that recruits one or more dendritic cells to temporarily reside within said device; and

    a positively charged polyethylenimine (PEI)-condensed toll-like receptor-9 (TLR-9)-activating CpG-ODN (PEI-CpG-ODN) which is retained in or on said scaffold polymer,wherein said PEI-CpG-ODN is present in an amount effective to overcome the trapping effect of the cytokine on said dendritic cells.

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