Patient directed therapy control

• US 10,258,798 B2
• Filed: 02/01/2016
• Issued: 04/16/2019
• Est. Priority Date: 09/26/2007
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Panken, Eric J., Denison, Timothy J., Molnar, Gregory F.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Ghand, Jennifer
• Application Number:
  US15/012,646
• Publication Number:
  US 20160158553A1
• Time in Patent Office: 1,170 Days
• CPC Class Codes: A61B 5/374 Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/7475 User input or interface means, e.g. keyboard, pointing device, joystick
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36031 using physiological parameters for adjustment
• CPC Class Codes: A61N 1/36034 specified by the stimulation parameters
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/37252 Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
• CPC Class Codes: G06F 3/015 Input arrangements based on nervous system activity detection, e.g. brain waves [EEG] detection, electromyograms [EMG] detection, electrodermal response detection

Abstract

A patient controls the delivery of therapy through volitional inputs that are detected by a biosignal within the brain. The volitional patient input may be directed towards performing a specific physical or mental activity, such as moving a muscle or performing a mathematical calculation. In one embodiment, a biosignal detection module monitors an electroencephalogram (EEG) signal from within the brain of the patient and determines whether the EEG signal includes the biosignal. In one embodiment, the biosignal detection module analyzes one or more frequency components of the EEG signal. In this manner, the patient may adjust therapy delivery by providing a volitional input that is detected by brain signals, wherein the volitional input may not require the interaction with another device, thereby eliminating the need for an external programmer to adjust therapy delivery. Example therapies include electrical stimulation, drug delivery, and delivery of sensory cues.

Claims

1. A system comprising:

a biosignal detection module configured to detect at least one biosignal from one or more muscles of a patient indicative of a volitional activity; and

a processor configured to control a therapy module to deliver electrical stimulation therapy to the patient, wherein the processor is configured to control the therapy module by controlling adjustment of a parameter of the electrical stimulation therapy based on the detected at least one biosignal, wherein the parameter of the electrical stimulation therapy comprises one or more of;

a current amplitude or a voltage amplitude of the electrical stimulation therapy;

a pulse width of the electrical stimulation therapy;

a pulse frequency of the electrical stimulation therapy;

an electrode combination of the electrical stimulation therapy;

or

an electrode polarity of one or more electrodes of the electrical stimulation therapy.

2. The system of claim 1, further comprising the therapy module configured to deliver to the patient the electrical stimulation therapy according to the adjusted parameter.

3. The system of claim 2, further comprising a feedback mechanism separate from the therapy module, wherein the processor is configured to, responsive to detecting the at least one biosignal, control the feedback mechanism to indicate the at least one biosignal was detected.

4. The system of claim 2, wherein the system comprises an implantable medical device comprising the biosignal detection module, the processor, and the therapy module.

5. The system of claim 1, wherein the at least one biosignal from one or more muscles of the patient indicative of the volitional activity is at least one electromyogram (EMG) signal from the patient indicative of the volitional activity.

6. The system of claim 1, wherein the volitional activity is a volitional muscle activity.

7. The system of claim 1, wherein the biosignal detection module is further configured to acquire an electrical signal from the one or more muscles of the patient, and wherein the processor is further configured to extract a predetermined frequency band from the electrical signal to detect the at least one biosignal.

8. The system of claim 1, wherein the biosignal detection module comprises one or more electrodes configured to be positioned to detect an electrical signal from a muscle of the patient.

9. The system of claim 1, wherein the processor is configured to control adjustment of the parameter of the electrical stimulation therapy by at least one of increasing or decreasing a value of the parameter or shifting between stored therapy programs.

10. A method comprising:

detecting, by a biosignal detection module, at least one biosignal from one or more muscles of a patient indicative of a volitional activity; and

controlling, by one or more processors, a therapy module to deliver electrical stimulation therapy to the patient by adjusting a parameter of the electrical stimulation therapy based on the detected at least one biosignal, wherein the parameter of the therapy comprises one or more of;

a current amplitude or a voltage amplitude of the electrical stimulation therapy;

a pulse width of the electrical stimulation therapy;

a pulse frequency of the electrical stimulation therapy;

an electrode combination of the electrical stimulation therapy;

or

an electrode polarity of one or more electrodes of the electrical stimulation therapy.

11. The method of claim 10, further comprising delivering, by the therapy module, the electrical stimulation therapy to the patient according to the adjusted parameter.

12. The method of claim 10, wherein the at least one biosignal from one or more muscles of the patient is at least one electromyogram (EMG) signal from the patient indicative of the volitional activity.

13. The method of claim 10, wherein the volitional activity is a volitional muscle activity.

14. The method of claim 10, wherein detecting the at least one biosignal from one or more muscles of the patient indicative of the volitional activity further comprises:

acquiring an electrical signal from a muscle of the patient; and

extracting, by the one or more processors, a predetermined frequency band from the electrical signal to detect the at least one biosignal.

15. The method of claim 14, wherein acquiring the electrical signal from the muscle of the patient comprises acquiring, by one or more electrodes, an electrical signal from the muscle of the patient.

16. The method of claim 10, further comprising controlling, by the one or more processors, a feedback mechanism to indicate the at least one biosignal was detected.

17. The method of claim 10, wherein controlling the therapy module by adjusting the parameter of the electrical stimulation therapy based on the detected at least one biosignal comprises controlling the therapy module by adjusting the parameter of the electrical stimulation therapy based on the detected at least one biosignal by at least one of increasing or decreasing a value of the parameter or shifting between stored therapy programs.

18. A system comprising:

means for detecting at least one biosignal from one or more muscles of a patient indicative of a volitional activity; and

means for controlling delivery of electrical stimulation therapy to the patient,

wherein the means for controlling the therapy module comprises means for controlling adjustment of a parameter of the electrical stimulation therapy based on the detected at least one biosignal, and

wherein the parameter of the electrical stimulation therapy comprises one or more of;

a current amplitude or a voltage amplitude of the electrical stimulation therapy;

a pulse width of the electrical stimulation therapy;

a pulse frequency of the electrical stimulation therapy;

an electrode combination of the electrical stimulation therapy;

or

an electrode polarity of one or more electrodes of the electrical stimulation therapy.

19. The system of claim 18, further comprising means for delivering the electrical stimulation therapy to the patient, wherein the means for delivering the electrical stimulation therapy to the patient comprises means for delivering the electrical stimulation therapy to the patient according to the adjusted parameter.

20. The system of claim 19, wherein the system comprises an implantable medical device comprising the means for detecting the at least one biosignal, the means for controlling delivery of the electrical stimulation therapy, and the means for delivering the electrical stimulation therapy to the patient.

21. A system comprising:

a biosignal detection module configured to detect at least one biosignal from one or more muscles of a patient indicative of a volitional activity; and

a processor configured to control a therapy module to deliver visual stimulation therapy to the patient, wherein the processor is configured to control the therapy module by controlling adjustment of a parameter of the visual stimulation therapy based on the detected at least one biosignal.

22. The system of claim 21, wherein the parameter of the visual stimulation therapy comprises one or more of:

a light pattern of the visual stimulation therapy;

a light color of the visual stimulation therapy;

a light pulse width of the visual stimulation therapy;

or

a light pulse rate of the visual stimulation therapy.

23. A method comprising:

detecting, by a biosignal detection module, at least one biosignal from one or more muscles of a patient indicative of a volitional activity; and

controlling, by one or more processors, a therapy module to deliver visual stimulation therapy to the patient by adjusting a parameter of the visual stimulation therapy based on the detected at least one biosignal.

24. The method of claim 23, wherein the parameter of the visual stimulation therapy comprises one or more of:

a light pattern of the visual stimulation therapy;

a light color of the visual stimulation therapy;

a light pulse width of the visual stimulation therapy;

or

a light pulse rate of the visual stimulation therapy.