Variants derived from ActRIIB and uses therefor
First Claim
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1. A variant ActRIIB protein consisting of the amino acid sequence of SEQ ID NO:
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Abstract
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
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11 Claims
- 1. A variant ActRIIB protein consisting of the amino acid sequence of SEQ ID NO:
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