Spectrometric systems and methods for improved focus localization of time- and space-varying measurements

• US 10,260,947 B2
• Filed: 08/06/2018
• Issued: 04/16/2019
• Est. Priority Date: 04/30/2012
• Status: Active Grant

• Current Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Original Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Inventors: Haider, Clifton R., Rose, James A., Delp, Gary S., Gilbert, Barry K.
• Primary Examiner(s): Ahmed, Jamil
• Application Number:
  US16/056,214
• Publication Number:
  US 20190033135A1
• Time in Patent Office: 253 Days
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: G01J 3/0237 Adjustable, e.g. focussing
• CPC Class Codes: G01J 3/42 Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry beam switching arrangements G01J3/08
• CPC Class Codes: G01N 21/49 within a body or fluid
• CPC Class Codes: G01N 33/4925 measuring blood gas content, e.g. O2, CO2 , HCO3

Abstract

A system and method of dynamically localizing a measurement of parameter characterizing tissue sample with waves produced by spectrometric system at multiple wavelengths and detected at a fixed location of the detector of the system. The parameter is calculated based on impulse response of the sample, reference data representing characteristics of material components of the sample, and path lengths through the sample corresponding to different wavelengths. Dynamic localization is effectuated by considering different portions of a curve representing the determined parameter, and provides for the formation of a spatial map of distribution of the parameter across the sample. Additional measurement of impulse response at multiple detectors facilitates determination of change of the measured parameter across the sample as a function of time.

Claims

1. A method for measurement of a beat-to-beat cardiac stroke volume variation of a living body with a spectrometric system that includes at least one transmitter and at least one receiver, the method comprising:

disposing the at least one transmitter on a surface of a region-of-interest (ROI) of the body, the ROI including a peripheral artery, and placing the at least one receiver on the body;

performing an oximetry measurement to acquire, with a data-processing circuitry of the spectrometric system, a time-dependent output from the at least one receiver caused by the at least one transmitter'"'"'s emission of at least one electromagnetic wave (EMW) at at least one corresponding wavelength,

wherein the time-dependent output represents time-dependent changes of a concentration of oxygen in arterial blood of the peripheral artery, of the ROI, determined along a path from the at least one transmitter to the at least one receiver, said path defined by a gradient of the concentration of oxygen in said arterial blood;

from the time-dependent output, creating a waveform that is a surrogate for a pulse pressure in an aorta; and

from changes in the waveform, identified as a function of time, determining the beat-to-beat cardiac stroke volume variation.

2. The method according to claim 1, wherein the determining the beat-to-beat cardiac stroke volume variation includes determining the beat-to-beat cardiac stroke volume based on the surrogate for the pulse pressure in the aorta, said surrogate representing a pulse of changes in the concentration of oxygen in the arterial blood.

3. The method according to claim 1, further comprising changing at least one of locations of the at least one transmitter and the at least one receiver to spatially localize said disposing and said placing by

determining impulse responses of the ROI for at least one transceiver pair at multiple wavelengths, the impulse responses being associated with emission of the at least one EMW by the at least one transmitter, the transceiver pair being a pair formed by the at least one transmitter and the at least one receiver.

4. The method according to claim 3, wherein the determining an impulse response, from the impulse responses, includes determining the impulse response of the ROI based on a time-dependent characteristic of the at least one transceiver pair,

wherein the at least one pair is identified at the data-processing circuitry of the system by a respectively corresponding excitation sequence series of pulses produced by the at least one transmitter, a first excitation sequence series of pulses at a first wavelength being orthogonal to a second excitation sequence series of pulses at a second wavelength.

5. The method according to claim 1, wherein the performing the oximetry measurement comprises acquiring an output representing an optical property that includes at least one of wavelength-dependent scattering, absorption, and anisotropy of said arterial blood.

6. The method according to claim 1, wherein the determining the beat-to-beat cardiac stroke volume includes determining changes of the concentration of oxygen along a path that is different from a path assumed by the use of Beer-Lambert'"'"'s law.

7. The method according to claim 1, further comprising determining a change of a size of the peripheral artery as a function of time during at least a systolic portion of an arterial pulse based on said concentration of oxygen.

8. The method according to claim 1, further comprising:

sampling a curve representing the time-dependent output as a function of time to obtain values of the concentration of oxygen at sampled points in time, and

forming a weighting function by calculating variance values among the values of the concentration of oxygen at the sampled points in time, the weighting function being defined by said variance values as a function of time.

9. The method according to claim 8, further comprising:

modifying a wavelength-dependent material parameter characterizing the sample based on (i) the computed impulse response that has been weighted by the weighting function and (ii) the reference data.

10. The method according to claim 1, further comprising:

at different wavelengths, modulating respectively-corresponding EMWs emitted by the at least one transmitter with first and second excitation sequences produced at the at least one transmitter, the first and second excitation sequences being orthogonal to one another.

11. The method according to claim 1, further comprising forming a spatial map of the determined concentration of oxygen across a cross-section of the ROI located between the at least one transmitter and the at least one receiver based on different portions of a curve representing said output as a function of time.

12. The method according to claim 1, further comprising adding a chemical substance to the living body, and wherein said performing includes determining a change in at least one wavelength-dependent material parameter caused by said adding.

13. The method according to claim 1, further comprising generating emission of said at least one transmitter as electromagnetic pulses in a defined excitation sequence and transmitting said pulses through a delay line with multiple delay taps to enhance a determination of a change in the concentration and to reduce a cost of the determining of the beat-to-beat cardiac stroke volume variation.

14. The method according to claim 1, further comprising enhancing localization of the determining the beat-to-beat cardiac stroke volume variation based on:

repositioning at least one transceiver pair along a surface of the ROI to a plurality of positions;

determining an impulse response of the ROI corresponding to each of the plurality of positions of the at least one transceiver pair to form a plurality of impulse responses and expressing the impulse responses from the plurality of impulse responses as impulse response curves; and

identifying a position, of the at least one transceiver pair, at which a respectively-corresponding impulse response curve exhibits the highest variance among variances of the plurality of impulse response curves,

wherein the at least one transceiver pair is a pair formed by the at least one transmitter and the at least one receiver.

15. The method according to claim 1, further comprising:

determining a change of a length of an effective passage of light from the at least one transmitter to the at least one receiver through the peripheral artery as a function of time during at least a systolic portion of an arterial pulse based on said concentration of oxygen.