Robust interferometer and methods of using same
First Claim
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1. A method for determining a characteristic property of a sample comprising the steps of:
- (a) providing a sample positioned inside a channel of a capillary tube, wherein the channel has a longitudinal direction and a transverse direction;
(b) interrogating the sample with a light beam, wherein the light beam is elongated in the longitudinal direction of the channel, such that the light beam is incident on at least a portion of the channel, wherein a length of the incidence is greater than 8 mm in length along the longitudinal direction; and
(c) generating scattered light through reflective and refractive interaction of the light beam with a substrate/channel interface and the sample, the scattered light comprising interference fringe patterns elongated in at least one direction, wherein the interference fringe patterns shift in response to changes in the refractive index of the sample.
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Abstract
Provided are improved optical detection systems and methods for using same, which systems and methods comprise single channel interferometric detection systems and methods for determining a characteristic property of samples. Such interferometric detection systems and methods employ a light beam that impinges two or more discrete zones along a channel, thereby avoiding variations that can result in increases in detection limits and/or measurement errors.
331 Citations
20 Claims
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1. A method for determining a characteristic property of a sample comprising the steps of:
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(a) providing a sample positioned inside a channel of a capillary tube, wherein the channel has a longitudinal direction and a transverse direction; (b) interrogating the sample with a light beam, wherein the light beam is elongated in the longitudinal direction of the channel, such that the light beam is incident on at least a portion of the channel, wherein a length of the incidence is greater than 8 mm in length along the longitudinal direction; and (c) generating scattered light through reflective and refractive interaction of the light beam with a substrate/channel interface and the sample, the scattered light comprising interference fringe patterns elongated in at least one direction, wherein the interference fringe patterns shift in response to changes in the refractive index of the sample. - View Dependent Claims (2, 3, 4)
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5. A method for determining a characteristic property of a sample comprising the steps of:
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(a) providing a capillary tube having a channel formed therein, wherein the channel has a longitudinal direction and a transverse direction, and wherein the channel is configured for reception of two or more liquid samples by having at least two inlets positioned at opposing locations of the channel, and at least one outlet positioned at a point between the at least two inlets, thereby defining a right side of the channel on one side of the at least one outlet and a left side of the channel on another side of the at least one outlet; (b) introducing a first sample into the left side of the channel; (c) introducing a second sample into the right side of the channel; (d) simultaneously interrogating the samples with a light beam, wherein the light beam is elongated in the longitudinal direction of the channel, such that the light beam is incident on at least a portion of the left side of the channel and the right side of the channel; and (e) generating scattered light through reflective and refractive interaction of the light beam with a substrate/channel interface and the samples, the scattered light comprising interference fringe patterns elongated in at least one direction, wherein the interference fringe patterns shift in response to changes in the refractive index of the sample. - View Dependent Claims (6, 7, 8, 9, 10)
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11. An interferometric detection system comprising:
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(a) a capillary tube having a channel formed therein, wherein the channel has a longitudinal direction and a transverse direction, and wherein the channel is configured for reception of two or more liquid samples by having at least two inlets positioned at opposing locations of the channel, and at least one outlet positioned at a point between the at least two inlets, thereby defining a right side of the channel on one side of the at least one outlet and a left side of the channel on another side of the at least one outlet; (b) a light source for generating a light beam, wherein the light beam is elongated in the longitudinal direction of the channel, and wherein the light source is positioned to direct the light beam onto the channel such that the light beam is simultaneously incident on at least a portion of the right side of the channel and at least a portion of the left side of the channel, such that, during operation, scattered light is generated through reflective and refractive interaction of the light beam with a channel interface and the two or more samples, the scattered light comprising interference fringe patterns elongated in at least one direction, wherein the interference fringe patterns shift in response to changes in the refractive index of the two or more samples; and (c) a photodetector for simultaneously receiving the scattered light and generating a plurality of intensity signals. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification