Apparatus and method for recording neural signals in the presence of artifacts

• US 10,264,988 B2
• Filed: 05/20/2016
• Issued: 04/23/2019
• Est. Priority Date: 02/23/2016
• Status: Active Grant

• Current Assignee: Charles Stark Draper Laboratory Incorporated
• Original Assignee: Charles Stark Draper Laboratory Incorporated
• Inventors: Nugent, Brian, Bousquet, Robert, Wheeler, Jesse J., Czarnecki, Andrew, Lachapelle, John
• Primary Examiner(s): McCrosky, David J.
• Application Number:
  US15/160,500
• Publication Number:
  US 20170238828A1
• Time in Patent Office: 1,068 Days
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/725 using specific filters therefor, e.g. Kalman or adaptive filters A61B5/316 take precedence
• CPC Class Codes: A61N 1/36139 with automatic adjustment

Abstract

Systems and methods are disclosed herein for recording electrical signals in the presence of artifacts. The system and methods can employ multiple techniques for attenuating large, unwanted artifacts while preserving lower amplitude desirable signals. Aspects that can improve the recording of electrical signals in the presence of larger artifacts include particular electrode placement and spacing, high dynamic range amplification with good linearity, and signal blanking. Combinations of more or fewer techniques can be employed to achieve the desired attenuation of signal artifacts while preserving the desired signal. The systems and methods are suitable for recording neural signals in the presence of electrical stimulation signals.

Claims

1. A system for recording of electrical signals in the presence of artifacts, comprising:

a stimulation electrode configured to introduce a stimulation signal;

a recording electrode configured to receive an electrical signal;

a blanking circuit electrically coupled to the recording electrode, the blanking circuit comprising a switch in parallel with a capacitor, wherein the switch effectively shorts the capacitor when closed;

an amplifier electrically coupled to the blanking circuit and configured to amplify the electrical signal, wherein the amplifier has a first gain when the switch is closed and a second gain lower than the first gain when the switch is open; and

a driver electrically coupled to the amplifier and configured to buffer the output of the amplifier, wherein;

the blanking circuit is located between the recording electrode and an input to the amplifier.

2. The system of claim 1, wherein the recording electrode is positioned at a distance from the stimulation electrode such that a stimulation signal emitted from the stimulation electrode is attenuated to a level at the recording electrode of between about one tenth and one thousandth of the initial signal magnitude.

3. The system of claim 1, wherein the stimulation electrode comprises a first electrode and a second electrode, the first electrode and second electrode configured to emit a stimulation signal at opposite polarities, and the recording electrode is positioned substantially equidistant from the first electrode and the second electrode.

4. The system of claim 1, wherein the amplifier comprises:

a first stage including a first differential amplifier; and

a second stage including a second differential amplifier, a first push-pull circuit coupled to a first output of the second differential amplifier, and a second push-pull circuit coupled to a second output of the second differential amplifier.

5. The system of claim 4, wherein the first stage comprises a first input FET, a second input FET, a first complementary FET coupled to the first input FET, and a second complementary FET coupled to the second input FET, wherein the first input FET and the second input FET are larger than the first complementary FET and the second complementary FET such that the first input FET and the second input FET have a lower thermal noise than the first complementary FET and the second complementary FET.

6. The system of claim 4, wherein the first stage has a third gain set by a first capacitive feedback circuit and the second stage has a fourth gain lower than the third gain set by a second capacitive feedback circuit.

7. The system of claim 4, wherein the second stage has higher thermal noise and/or lower power than the first stage.

8. The system of claim 1, wherein the amplifier is a differential amplifier having a first output and a second output, and wherein the driver comprises:

a first complimentary input differential pair coupled to the first output;

a second complimentary input differential pair coupled to the second output;

a class A/B circuit coupled to the first complimentary input differential pair and the second complimentary input differential pair; and

a push-pull circuit coupled to the class A/B circuit.

9. The system of claim 8, wherein the driver has unity gain.

10. The system of claim 1, further comprising a low-pass filter having a first cutoff frequency and a high-pass filter having a second cutoff frequency lower than the first cutoff frequency.

11. A method of recording of electrical signals in the presence of artifacts, comprising:

emitting, by a stimulation electrode placed in proximity to a region of interest, a stimulation signal;

receiving, by a recording electrode placed in proximity to the region of interest, an electrical signal responsive to the stimulation signal;

amplifying, by an amplifier electrically coupled to the recording electrode, the electrical signal;

reducing, by a blanking circuit electrically coupled to the amplifier, and located between an input to the amplifier and the recording electrode, a gain of the amplifier, the blanking circuit comprising a switch in parallel with a capacitor, wherein the switch effectively shorts the capacitor when closed, and wherein the amplifier has a first gain when the switch is closed and a second gain lower than the first gain when the switch is open;

buffering, by a driver electrically coupled to the amplifier, the amplified signal; and

recording the buffered signal.

12. The method of claim 11, further comprising positioning the stimulation electrode at a distance from the stimulation electrode such that a stimulation signal emitted from the stimulation electrode is attenuated to a level at the recording electrode of between about one tenth and one thousandth of the initial signal magnitude.

13. The method of claim 11, wherein the stimulation electrode comprises a first electrode and a second electrode, the first electrode and second electrode configured to emit a stimulation signal at opposite polarities, the method further comprising:

positioning the recording electrode substantially equidistant from the first electrode and the second electrode.

14. The method of claim 11, wherein the amplifier comprises:

a first stage including a first differential amplifier; and

a second stage including a second differential amplifier, a first push-pull circuit coupled to a first output of the second differential amplifier, and a second push-pull circuit coupled to a second output of the second differential amplifier.

15. The method of claim 14, wherein the first stage comprises a first input FET, a second input FET, a first complementary FET coupled to the first input FET, and a second complementary FET coupled to the second input FET, wherein the first input FET and the second input FET are larger than the first complementary FET and the second complementary FET such that the first input FET and the second input FET have a lower thermal noise than the first complementary FET and the second complementary FET.

16. The method of claim 14, wherein the first stage has a third gain set by a first capacitive feedback circuit and the second stage has a fourth gain lower than the third gain set by a second capacitive feedback circuit.

17. The method of claim 14, wherein the second stage has higher thermal noise and/or lower power than the first stage.

18. The method of claim 11, wherein the amplifier is a differential amplifier having a first output and a second output, and wherein the driver comprises:

a first complimentary input differential pair coupled to the first output;

a second complimentary input differential pair coupled to the second output;

a class A/B circuit coupled to the first complimentary input differential pair and the second complimentary input differential pair; and

a push-pull circuit coupled to the class A/B circuit.

19. The method of claim 18, wherein the driver has unity gain.

20. The method of claim 11, further comprising filtering the electrical signal by a filter electrically coupled to the amplifier, wherein the filter comprises a low-pass filter having a first cutoff frequency and a high-pass filter having a second cutoff frequency lower than the first cutoff frequency.