Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement

• US 10,265,155 B2
• Filed: 09/30/2014
• Issued: 04/23/2019
• Est. Priority Date: 02/12/2007
• Status: Active Grant

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Lu, Helen H., Spalazzi, Jeffrey, Moffat, Kristen L., Levine, William N.
• Primary Examiner(s): Stewart, Alvin
• Application Number:
  US14/503,053
• Publication Number:
  US 20150100121A1
• Time in Patent Office: 1,666 Days
• Field of Search: 623 2372- 2376
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61F 2/0811 Fixation devices for tendons or ligaments
• CPC Class Codes: A61F 2002/0858 Fixation of tendon or ligament between anchor and bone, e.g. interference screws, wedges
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 35/32 Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
• CPC Class Codes: A61K 38/18 Growth factors; Growth regulators
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61L 2430/10 for reconstruction of tendons or ligaments
• CPC Class Codes: A61L 2430/34 for soft tissue reconstruction
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: B29C 67/04 Sintering combined with compression B29C43/00

Abstract

An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.

Claims

1. A scaffold apparatus for fixing musculoskeletal soft tissue to bone in a subject, said scaffold apparatus comprising (i) a graft collar and (ii) a polymer-fiber nanofiber mesh wrapped around the graft collar so as to apply compressive mechanical loading to the graft collar.

2. The scaffold apparatus of claim 1, wherein an outer surface of the graft collar is wrapped in its entirety by the polymer-fiber nanofiber mesh.

3. The scaffold apparatus of claim 1, wherein the graft collar is biphasic.

4. The scaffold apparatus of claim 3, wherein the biphasic graft collar includes a first phase comprising a material which promotes growth and proliferation of chondrocytes, and a second phase adjacent to the first phase comprising a material which promotes the growth and proliferation of osteoblasts.

5. The scaffold apparatus of claim 1, wherein the nanofiber mesh comprises polylactide-co-glycolide (PLGA).

6. The scaffold apparatus of claim 1, wherein the nanofiber mesh is electrospun.

7. The scaffold apparatus of claim 1, wherein the scaffold apparatus is coupled to a soft tissue graft.

8. The apparatus of claim 7, wherein the soft tissue graft is a graft for a ligament of the subject.

9. The apparatus of claim 8, wherein the ligament is an anterior cruciate ligament of the subject.

10. An graft-fixation apparatus comprising the scaffold apparatus of claim 1.

11. The apparatus of claim 10, wherein the graft fixation apparatus is an interference screw.