Ocular collar stent for treating narrowing of the irideocorneal angle

• US 10,265,161 B2
• Filed: 03/03/2016
• Issued: 04/23/2019
• Est. Priority Date: 08/07/2012
• Status: Active Grant

• Current Assignee: Peter Renke
• Original Assignee: Regeneye L. L. C.
• Inventors: Renke, Peter
• Primary Examiner(s): Klein, Benjamin
• Application Number:
  US15/060,122
• Publication Number:
  US 20160184087A1
• Time in Patent Office: 1,146 Days
• CPC Class Codes: A61F 2/15 Implant having one or more holes, e.g. for nutrient transport, for facilitating handling
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002

Abstract

An ocular stent for insertion in an anterior chamber of an eye is provided. The stent facilitates the restoration of the structure of an irideocorneal angle of the anterior chamber for treating structural changes from ocular aging. The stent includes: a continuous annular central portion; an anterior portion protruding in an anterior direction from the central portion and being configured to provide variable contact around a circumference of the stent with a surface of a transition zone between a trabecular meshwork and a corneal endothelium of the eye; and a posterior portion extending in a posterior direction from the central portion, the posterior portion being configured to contact a portion of a peripheral iris of the eye. A method for stabilizing the irideocorneal angle of the anterior chamber using a stent is also disclosed herein.

Claims

1. An annular ocular stent for insertion in an irideocorneal angle of an anterior chamber of an eye, the stent comprising:

a continuous annular central portion;

an anterior portion protruding in an anterior direction from the central portion and being configured to provide variable contact around a circumference of the stent with a surface of a transition zone between a trabecular meshwork and a corneal endothelium of the eye; and

a posterior portion extending in a posterior direction from the central portion, the posterior portion being configured to contact a portion of a peripheral iris of the eye,

wherein the posterior portion comprises a plurality of posterior supports extending radially along a posterior surface of the central portion from an inner radial edge of the central portion toward an outer radial edge of the central portion.

2. The stent of claim 1, wherein the anterior portion is further configured to contact at least a portion of an anterior portion of the trabecular meshwork, and wherein the posterior portion is further configured to extend around the irideocorneal angle and to cross an anterior chamber exposure of a ciliary body up to or beyond a scleral spur of the eye.

3. The stent of claim 1, wherein the stent further comprises at least one communication structure for equalizing fluid pressure across the stent, when the stent is inserted in the irideocorneal angle of the eye.

4. The stent of claim 3, wherein the communication structure comprises a through-hole extending radially through the stent.

5. The stent of claim 1, wherein the posterior portion of the stent extends radially outwardly from the central portion such that, when the stent is inserted in the anterior chamber of the eye, a radially outermost portion of the posterior portion of the stent is configured to be received within the irideocorneal angle of the eye.

6. The stent of claim 1, wherein the anterior portion defines an anterior outer diameter and the posterior portion defines a posterior outer diameter, and wherein the posterior outer diameter is greater than the anterior outer diameter.

7. The stent of claim 1, wherein the stent is formed from one or more of:

polymethylmethacrylate (PMMA), silicone or acrylic block polymers materials having PMMA components, hydrophobic acrylics, hydrophilic acrylics, acrylic poly(styrene-block-isobutylene-block-styrene), silicon elastomer, and heparin surface modified acrylics.

8. The stent of claim 1, further comprising a coating on at least a portion of a surface of the stent, wherein the coating is formed from a material that increases at least one of biocompatibility and durability of the stent.

9. The stent of claim 1, wherein the stent is at least one of foldable and rollable, such that the stent can be at least one of folded or rolled during insertion and unfolded or unrolled once inserted in the anterior chamber.

10. The stent of claim 1, wherein the anterior portion comprises a plurality of beads extending from the central portion, the beads being disposed in a side by side arrangement around the circumference of the stent and configured for providing variable contact with the transition zone between the trabecular meshwork and the corneal endothelium.

11. The stent of claim 1, wherein the posterior supports extend in a radial direction beyond the outer radial edge of the central portion.

12. The stent of claim 11, wherein the posterior supports and the posterior surface of the central portion define channels extending radially through the stent, the channels being configured to permit fluid communication through the stent for equalization of fluid pressure within the anterior chamber of the eye.

13. The stent of claim 11, wherein the posterior supports comprise a rounded inner end portion, a rounded outer end portion, and a middle portion extending therebetween, the middle portion being tapered, such that a width of an inner end of the middle portion is greater than a width of an outer end of the middle portion.

14. The stent of claim 1, wherein the central portion, the anterior portion, and the posterior portion are integrally formed.

15. An annular ocular stent for insertion in an irideocorneal angle of an anterior chamber of an eye, the stent comprising:

a continuous annular body defining a rounded anterior surface and a posterior surface;

a plurality of anterior protrusions integrally formed with and extending from the anterior surface, the anterior protrusions being configured to contact portions of a surface of a transition zone between a trabecular meshwork and a corneal endothelium of the eye to provide variable contact therewith about a circumference of the stent; and

a plurality of posterior supports integrally formed with and protruding from the posterior surface of the body and extending radially along the posterior surface thereof from an inner radial edge of the body toward an outer radial edge thereof, the supports being configured to contact a peripheral iris of the eye.

16. The stent of claim 15, wherein the posterior supports comprise a rounded inner radial portion, a rounded outer radial portion, and a middle portion extending therebetween, and wherein at least a portion of the outer radial portion of the posterior supports extends radially beyond the outer radial edge of the body.

17. The stent of claim 16, wherein the outer radial portions of the posterior supports are configured to be received within the irideocorneal angle of the eye.

18. A method of stabilizing an irideocorneal angle of an anterior chamber of an eye, the method comprising:

providing an annular ocular stent comprising a continuous annular central portion, an anterior portion protruding in an anterior direction from the central portion and being configured to provide variable contact around a circumference of the stent with a surface of a transition zone between a trabecular meshwork and a corneal endothelium of the eye, and a posterior portion extending in a posterior direction from the central portion, the posterior portion being configured to contact a portion of a peripheral iris of the eye, wherein the posterior portion comprises a plurality of posterior supports extending radially along a posterior surface of the central portion from an inner radial edge of the central portion toward an outer radial edge of the central portion;

inserting the stent into the anterior chamber of the eye, such that the stent is in contact with soft tissue of the anterior chamber; and

stabilizing the irideocorneal angle of the anterior chamber of the eye by simultaneously applying pressure in an anterior direction with the anterior portion of the stent to portions of the surface of the transition zone between the trabecular meshwork and the corneal endothelium of the eye and in a posterior direction with the plurality of posterior supports of the posterior portion of the stent to the peripheral iris of the eye.

19. The method of claim 18, wherein inserting the stent into the anterior chamber comprises:

forming an incision in a cornea of the eye for accessing the anterior chamber;

inserting a portion of an injector into the anterior chamber through the incision; and

expelling the stent from the injector to the anterior chamber for placement.