Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
First Claim
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1. A method of treating a subject having a mast cell related disorder comprising:
- (a) determining whether a subject has an increased concentration of one or more biomarkers in the blood of the subject; and
(b) administering to a subject having an increased concentration of the one or more biomarkers in the blood of the subject a composition comprising a mast cell stabilizer;
wherein the one or more biomarkers is selected from tryptase, histamine, chymase, interleukin-6, interleukin-4, interleukin-5, interleukin-8, tumor growth factor alpha (TGF-α
), tumor growth factor beta (TGF-β
), tumor necrosis factor alpha (TNF-α
), tumor necrosis factor beta (TNF-β
), fibroblast growth factor 2 (FGF2), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), stem cell factor (SCF), vascular cell adhesion molecule 1 (VCAM-1), ICAM-1 (Intercellular Adhesion Molecule
1), immunoglobulin E (IgE), matrix metalloproteinase-3 (MMP-3), matrix metallopeptidase-9 (MMP-9), vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor C (VEGF-C), vascular endothelial growth factor D (VEGF-D) macrophage inflammatory protein 1α
(MIP-1α
), N-methyl histamine, methylimidazole acetic acid, and prostaglandin D2.
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Abstract
Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
256 Citations
54 Claims
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1. A method of treating a subject having a mast cell related disorder comprising:
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(a) determining whether a subject has an increased concentration of one or more biomarkers in the blood of the subject; and (b) administering to a subject having an increased concentration of the one or more biomarkers in the blood of the subject a composition comprising a mast cell stabilizer; wherein the one or more biomarkers is selected from tryptase, histamine, chymase, interleukin-6, interleukin-4, interleukin-5, interleukin-8, tumor growth factor alpha (TGF-α
), tumor growth factor beta (TGF-β
), tumor necrosis factor alpha (TNF-α
), tumor necrosis factor beta (TNF-β
), fibroblast growth factor 2 (FGF2), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), stem cell factor (SCF), vascular cell adhesion molecule 1 (VCAM-1), ICAM-1 (Intercellular Adhesion Molecule
1), immunoglobulin E (IgE), matrix metalloproteinase-3 (MMP-3), matrix metallopeptidase-9 (MMP-9), vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor C (VEGF-C), vascular endothelial growth factor D (VEGF-D) macrophage inflammatory protein 1α
(MIP-1α
), N-methyl histamine, methylimidazole acetic acid, and prostaglandin D2.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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54. A method of treating a subject having a mast cell related disorder, comprising administering to the subject an aerosol of a composition comprising cromolyn sodium, wherein said composition has an osmolality of between about 30 mOsm/kg to about 145 mOsm/kg, wherein the subject has an increased concentration of one or more biomarkers in the blood of the subject, wherein the one or more biomarkers is selected from tryptase, histamine, chymase, interleukin-6, interleukin-4, interleukin-5, interleukin-8, tumor growth factor alpha (TGF-α
- ), tumor growth factor beta (TGF-β
), tumor necrosis factor alpha (TNF-α
), tumor necrosis factor beta (TNF-β
), fibroblast growth factor 2 (FGF2), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), stem cell factor (SCF), vascular cell adhesion molecule 1 (VCAM-1), ICAM-1 (Intercellular Adhesion Molecule
1), immunoglobulin E (IgE), matrix metalloproteinase-3 (MMP-3), matrix metallopeptidase-9 (MMP-9), vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor C (VEGF-C), vascular endothelial growth factor D (VEGF-D) macrophage inflammatory protein 1α
(MIP-1α
), N-methyl histamine, methylimidazole acetic acid, and prostaglandin D2.
- ), tumor growth factor beta (TGF-β
Specification