Immobilized bioactive hydrogel matrices as surface coatings

• US 10,265,436 B2
• Filed: 03/10/2017
• Issued: 04/23/2019
• Est. Priority Date: 02/21/2002
• Status: Expired due to Term

• Current Assignee: Pioneer Surgical Technology Incorporated (Surgalign Holdings, Inc.)
• Original Assignee: Pioneer Surgical Technology Incorporated (Surgalign Holdings, Inc.)
• Inventors: Lamberti, Francis Vincent, Klann, Richard Chris, Hill, Ronald Stewart
• Primary Examiner(s): Arnold, Ernst V
• Application Number:
  US15/455,192
• Publication Number:
  US 20170182215A1
• Time in Patent Office: 774 Days
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61L 2300/112 Phosphorus-containing compounds, e.g. phosphates, phosphonates
• CPC Class Codes: A61L 2300/412 Tissue-regenerating or healing or proliferative agents
• CPC Class Codes: A61L 2420/04 Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases
• CPC Class Codes: A61L 2420/06 Coatings containing a mixture of two or more compounds
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/025 Other specific inorganic materials not covered by A61L27/04 - A61L27/12
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/22 Polypeptides or derivatives thereof , e.g. degradation products
• CPC Class Codes: A61L 27/222 Gelatin
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/10 : Macromolecular materials
• CPC Class Codes: A61P 19/00 : Drugs for skeletal disorders
• CPC Class Codes: A61P 37/00 : Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 7/00 : Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: B29C 39/003 : characterised by the choice of material
• CPC Class Codes: B29L 2031/7532 : Artificial members, protheses
• CPC Class Codes: C08L 5/02 : Dextran; Derivatives thereof
• CPC Class Codes: C08L 89/00 : Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: Y10T 428/29 : Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
• CPC Class Codes: Y10T 428/2947 : Synthetic resin or polymer in plural coatings, each of different type
• CPC Class Codes: Y10T 428/31551 : Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31786 : Of polyester [e.g., alkyd, etc.]

Abstract

The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.

Claims

1. A coated implant comprising:

an implant having a surface; and

a hydrogel matrix overlying at least a portion of the surface of the implant, the hydrogel matrix comprising a polyglycan and a polypeptide and being effective to improve one or both of vascularity and osteointegration of the implant, and wherein the hydrogel matrix comprises one or both of polar amino acids and a divalent cation chelator;

wherein the coated implant is a bone repair implant; and

wherein one or more of the following conditions applies;

the hydrogel matrix is immobilized on at least a portion of the surface of the implant by at least one of the polyglycan and polypeptide being covalently cross-linked to the implant surface;

the polyglycan and polypeptide are covalently cross-linked to each other;

the coated implant comprises hydroxyapatite;

the coated implant comprises demineralized bone;

the coated implant comprises a ceramic material.

2. The coated implant according to claim 1, wherein the hydrogel matrix comprises the polar amino acids.

3. The coated implant according to claim 1, wherein the hydrogel matrix comprises the divalent cation chelator.

4. The coated implant according to claim 1, wherein the hydrogel matrix is solid or semi-solid at physiological temperature and physiological pH.

5. The coated implant according to claim 1, wherein the polyglycan is dextran or oxidized dextran, and the polypeptide is gelatin.

6. The coated implant according to claim 1, wherein the polyglycan is a polysaccharide or a sulfated polysaccharide.

7. The coated implant according to claim 6, wherein the polysaccharide is selected from the group consisting of dextran, heparan, heparin, hyaluronic acid, alginate, agarose, carrageenan, amylopectin, amylose, glycogen, starch, cellulose, and chitin;

and wherein the sulfated polysaccharide is selected from the group consisting of heparan sulfate, chondroitin sulfate, dextran sulfate, dermatan sulfate, and keratan sulfate.

8. The coated implant according to claim 1, wherein the polypeptide is a tissue-derived polypeptide selected from the group consisting of collagens, gelatins, keratin, decorin, aggrecan, and glycoproteins.

9. The coated implant according to claim 1, wherein the coated implant comprises a metallic material.