Point-and-click programming for deep brain stimulation using real-time monopolar review trendlines

• US 10,265,532 B2
• Filed: 05/29/2018
• Issued: 04/23/2019
• Est. Priority Date: 08/28/2012
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Carcieri, Stephen, Chen, Dean, Moffitt, Michael A.
• Primary Examiner(s): Fairchild, Mallika D
• Application Number:
  US15/991,807
• Publication Number:
  US 20180272143A1
• Time in Patent Office: 329 Days
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

A system and method for selecting leadwire stimulation parameters includes a processor iteratively performing, for each of a plurality of values for a particular stimulation parameter, each value corresponding to a respective current field: (a) shifting the current field longitudinally and/or rotationally to a respective plurality of locations about the leadwire; and (b) for each of the respective plurality of locations, obtaining clinical effect information regarding a respective stimulation of the patient tissue produced by the respective current field at the respective location; and displaying a graph plotting the clinical effect information against values for the particular stimulation parameter and locations about the leadwire, and/or based on the obtained clinical effect information, identifying an optimal combination of a selected value for the particular stimulation parameter and selected location about the leadwire at which to perform a stimulation using the selected value.

Claims

1. A non-transitory computer-readable medium containing instructions to perform a method for selecting electrical stimulation parameters for a leadwire implanted in patient tissue, the method comprising:

displaying a graph of a plurality of values for a particular stimulation parameter versus a plurality of locations about the leadwire;

receiving a user selection of a point on the graph, wherein the point corresponds to a first value of the particular stimulation parameter and a first location about the leadwire; and

initiating a signal to program an implantable pulse generator with the first value of the particular stimulation parameter and a selection of one or more electrodes on the leadwire corresponding to the first location about the leadwire to produce a stimulation.

2. The non-transitory computer-readable medium of claim 1, wherein the method further comprises, for each of the values for the particular stimulation parameter, each of the values corresponding to a respective current field, obtaining clinical effect information regarding a respective stimulation of the patient tissue produced by the respective current field at each of a respective plurality of locations about the leadwire;

wherein displaying the graph comprises displaying the graph plotting the obtained clinical effect information against the values for the particular stimulation parameter and the locations about the leadwire.

3. The non-transitory computer-readable medium of claim 2, wherein the obtained clinical effect information includes therapeutic effect values and adverse side effect values.

4. The non-transitory computer-readable medium of claim 1, wherein displaying the graph comprises displaying the graph as respective data points, wherein each data point is characterized by an angle of rotation and a radius from a center of the graph, wherein the radius corresponds to the value for the particular stimulation parameter associated with the data point and the angle of rotation corresponds to a direction characterizing a current field associated with the data point.

5. The non-transitory computer-readable medium of claim 1, wherein the locations differ longitudinally and rotationally about the leadwire.

6. The non-transitory computer-readable medium of claim 5, wherein the graph has three dimensions, variations in longitudinal location about the leadwire being plotted along a first one of the three dimensions of the graph and variations in rotational location about the leadwire being plotted along a second one of the three dimensions of the graph.

7. The non-transitory computer-readable medium of claim 1, wherein one or more of the locations correspond to an actual location of an electrode of the leadwire.

8. The non-transitory computer-readable medium of claim 1, wherein one or more of the locations correspond to a virtual location of an electrode of the leadwire corresponding to a current field producible by a combination of a respective subset of electrodes of the leadwire.

9. The non-transitory computer-readable medium of claim 1, wherein the method further comprises displaying an annotation control interface comprising a symptoms section listing one or more symptoms and providing controls for inputting a respective degree of a therapeutic effect for the respective symptom.

10. The non-transitory computer-readable medium of claim 9, wherein the annotation control interface further comprising a side effect section listing one or more side effects and providing controls for inputting a respective degree of the respective side effect.

11. A system for selecting electrical stimulation parameters and stimulating patient tissue using the selected electrical stimulation parameters, the system comprising:

a leadwire configured for implantation in the patient tissue;

an implantable pulse generator coupleable to the leadwire and configured to stimulate the patient tissue; and

a computer processor configured for;

displaying a graph of a plurality of values for a particular stimulation parameter versus a plurality of locations about the leadwire;

receiving a user selection of a point on the graph, wherein the point corresponds to a first value of the particular stimulation parameter and a first location about the leadwire; and

initiating a signal to program the implantable pulse generator with the first value of the particular stimulation parameter and a selection of one or more electrodes on the leadwire corresponding to the first location about the leadwire to produce a stimulation;

wherein the implantable pulse generator and the leadwire are configured and arranged to stimulate the patient tissue, when programmed, using the first value of the particular stimulation parameter and the selection of the one or more electrodes on the leadwire.

12. The system of claim 11, wherein the computer processor is further configured to, for each of the values for the particular stimulation parameter, each of the values corresponding to a respective current field, obtaining clinical effect information regarding a respective stimulation of the patient tissue produced by the respective current field at each of a respective plurality of locations about the leadwire;

wherein displaying the graph comprises displaying the graph plotting the obtained clinical effect information against the values for the particular stimulation parameter and the locations about the leadwire.

13. The system of claim 12, wherein the obtained clinical effect information includes therapeutic effect values and adverse side effect values.

14. The system of claim 11, wherein displaying a graph comprises displaying the graph plotting the obtained clinical effect information as respective data points, wherein each data point is characterized by an angle of rotation and a radius from a center of the graph, wherein the radius corresponds to the value for the particular stimulation parameter associated with the data point and the angle of rotation corresponds to a direction characterizing a current field associated with the data point.

15. The system of claim 11, wherein the locations differ longitudinally and rotationally about the leadwire.

16. The system of claim 15, wherein the graph has three dimensions, variations in longitudinal location about the leadwire being plotted along a first one of the three dimensions of the graph and variations in rotational location about the leadwire being plotted along a second one of the three dimensions of the graph.

17. The system of claim 11, wherein one or more of the locations correspond to an actual location of an electrode of the leadwire.

18. The system of claim 11, wherein one or more of the locations correspond to a virtual location of an electrode of the leadwire corresponding to a current field producible by a combination of a respective subset of electrodes of the leadwire.

19. The system of claim 11, wherein the computer processor is further configured to display an annotation control interface comprising a symptoms section listing one or more symptoms and providing controls for inputting a respective degree of a therapeutic effect for the respective symptom.

20. The system of claim 19, wherein the annotation control interface further comprising a side effect section listing one or more side effects and providing controls for inputting a respective degree of the side effect.