Detection of worsening heart failure
First Claim
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1. A system for detecting a target physiological event, the system comprising:
- a physiological sensor circuit including a sense amplifier circuit to sense a first physiological signal;
a signal processor circuit coupled to the physiological sensor circuit, the signal processor circuit including;
a predictor circuit configured to generate a first predictor trend using the first physiological signal, the first predictor trend indicating a change of the first physiological signal over time; and
a signal transformation circuit configured to transform the first predictor trend into transformed indices using a comparison of the first predictor trend to a first plurality of threshold pairs each including an onset threshold and a reset threshold; and
a detector circuit coupled to the signal processor circuit, the detector circuit configured to detect the target physiological event using the transformed indices; and
an output circuit configured to generate a human-perceptible alert in response to the transformed indices satisfying a detection criterion.
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Abstract
Systems and methods for detecting a target cardiac condition such as events indicative of worsening heart failure are described. A system may include sensor circuits for sensing physiological signals and a signal processor for generating a predictor trend indicative of temporal change of the physiological signal. The predictor trend may be transformed into a sequence of transformed indices using a codebook that includes a plurality of threshold pairs each including onset and reset thresholds. The codebook may be constructed and updated using physiological data. The system may detect target cardiac condition using the transformed indices.
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Citations
20 Claims
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1. A system for detecting a target physiological event, the system comprising:
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a physiological sensor circuit including a sense amplifier circuit to sense a first physiological signal; a signal processor circuit coupled to the physiological sensor circuit, the signal processor circuit including; a predictor circuit configured to generate a first predictor trend using the first physiological signal, the first predictor trend indicating a change of the first physiological signal over time; and a signal transformation circuit configured to transform the first predictor trend into transformed indices using a comparison of the first predictor trend to a first plurality of threshold pairs each including an onset threshold and a reset threshold; and a detector circuit coupled to the signal processor circuit, the detector circuit configured to detect the target physiological event using the transformed indices; and an output circuit configured to generate a human-perceptible alert in response to the transformed indices satisfying a detection criterion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for detecting a target physiological event, the method comprising:
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sensing a first physiological signal; processing the first physiological signal to generate a first predictor trend indicating a change of the first physiological signal over time; transforming the first predictor trend into transformed indices using a comparison of the first predictor trend to a first plurality of threshold pairs each including an onset threshold and a reset threshold; detecting the target physiological event using the transformed indices; and generating a human-perceptible alert in response to the transformed indices satisfying a detection criterion. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification