Bone cement and methods of use thereof

• US 10,272,174 B2
• Filed: 04/19/2017
• Issued: 04/30/2019
• Est. Priority Date: 09/14/2006
• Status: Active Grant

• Current Assignee: Depuy Synthes Products Incorporated (Johnson & Johnson)
• Original Assignee: Depuy Synthes Products Incorporated (Johnson & Johnson)
• Inventors: Beyar, Mordechay, Globerman, Oren
• Primary Examiner(s): Pepitone, Michael F
• Application Number:
  US15/491,214
• Publication Number:
  US 20170216483A1
• Time in Patent Office: 741 Days
• CPC Class Codes: A61K 6/15 Compositions characterised by their physical properties
• CPC Class Codes: A61L 24/0005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 24/02 containing inorganic materials
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 24/06 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043, A61L24/046 take precedence
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: C08L 33/12 Homopolymers or copolymers of methyl methacrylate

Abstract

A bone cement comprising an acrylic polymer mixture which is formulated to have a relatively high viscosity for a relatively long window, due to distributions of molecular weights and/or sizes of acrylic beads.

Claims

1. A bone cement comprising an acrylic polymer mixture, the cement characterized in that it achieves a viscosity of at least 500 Pascal-second within 180 seconds following initiation of mixing of a monomer component and a polymer component and characterized by sufficient biocompatibility to permit in-vivo use;

wherein the mixture includes PMMA;

wherein the PMMA is provided as a population of beads divided into at least three sub-populations, each sub-population characterized by an average bead diameter.

2. A bone cement according to claim 1, wherein the viscosity of the mixture remains between 500 and 2000 Pascal-second for a working window of at least 5 minutes after the initial period.

3. A bone cement according to claim 2, wherein the working window is at least 8 minutes long.

4. A bone cement according to claim 1, wherein the mixture includes Barium Sulfate.

5. A bone cement according to claim 1, wherein the PMMA is provided as a PMMA/styrene copolymer.

6. A bone cement according to claim 1, wherein the PMMA is provided as a population of beads divided into at least two sub-populations, each sub-population characterized by an average molecular weight.

7. A bone cement according to claim 6, wherein a largest sub-population of PMMA beads is characterized by an MW of 150,000 Dalton to 300,000 Dalton.

8. A bone cement according to claim 6, wherein a largest sub-population of PMMA beads includes 90-98% (w/w) of the beads.

9. A bone cement according to claim 6, wherein a high molecular weight sub-population of PMMA beads is characterized by an average MW of at least 3,000,000 Dalton.

10. A bone cement according to claim 6, wherein a high molecular weight sub-population of PMMA beads includes 2 to 3% (w/w) of the beads.

11. A bone cement according to claim 6, wherein a low molecular weight sub-population of PMMA beads is characterized by an average MW of less than 15,000 Dalton.

12. A bone cement according to claim 6, wherein a low molecular weight sub-population of PMMA beads includes 0.75 to 1.5% (W/W) of the beads.

13. A bone cement according to claim 1, wherein at least one bead sub-population of characterized by an average diameter is further divided into at least two sub-sub-populations, each sub-sub-population characterized by an average molecular weight.

14. A bone cement according to claim 1, further comprising processed bone and/or synthetic bone.

15. A bone cement according to claim 1, characterized in that the cement achieves a viscosity of at least 500 Pascal-second when 100% of a polymer component is wetted by a monomer component.

16. A bone cement according to claim 1, wherein the viscosity is at least 800 Pascal-second.

17. A bone cement according to claim 1, wherein the viscosity is at least 1500 Pascal-second.