Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall

• US 10,272,260 B2
• Filed: 05/23/2014
• Issued: 04/30/2019
• Est. Priority Date: 11/23/2011
• Status: Active Grant

• Current Assignee: Broncus Medical Incorporated
• Original Assignee: Broncus Medical Incorporated
• Inventors: Kaplan, Gary S., Laufer, Michael D., Keast, Thomas M., Cole, Cary, Wibowo, Henky, Roschak, Edmund J.
• Primary Examiner(s): Gilbert, Andrew M
• Application Number:
  US14/286,689
• Publication Number:
  US 20140343348A1
• Time in Patent Office: 1,803 Days
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61B 17/32 Surgical cutting instruments A61B18/042 takes precedence; suture cutters A61B17/0467; instruments for ligaturing or cutting A61B17/128; instruments for rupturing the amniotic membrane A61B17/4208; specially adapted knives for eye surgery A61F9/0133
• CPC Class Codes: A61B 17/32002 with continuously rotating, oscillating or reciprocating cutting instruments
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 2017/00809 Lung operations
• CPC Class Codes: A61B 2017/0417 T-fasteners
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61B 2034/2051 Electromagnetic tracking systems
• CPC Class Codes: A61B 2090/034 abutting on parts of the device itself
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: A61F 2/94 Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
• CPC Class Codes: A61M 1/84 Drainage tubes; Aspiration tips for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32
• CPC Class Codes: A61M 2005/006 for gases, e.g. CO2
• CPC Class Codes: A61M 2005/1585 Needle inserters
• CPC Class Codes: A61M 2025/0081 : Soft tip
• CPC Class Codes: A61M 2025/0095 : being one or more needles protruding from the distal tip and which are not used for injection nor for electro-stimulation, e.g. for fixation purposes
• CPC Class Codes: A61M 2202/0208 : Oxygen
• CPC Class Codes: A61M 2210/1039 : Lungs
• CPC Class Codes: A61M 25/10 : Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 27/002 : Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61M 5/158 : Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
• CPC Class Codes: A61N 2005/1098 : Enhancing the effect of the particle by an injected agent or implanted device
• CPC Class Codes: A61N 5/062 : Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61N 5/1002 : Intraluminal radiation therapy
• CPC Class Codes: A61N 5/1007 : Arrangements or means for the introduction of sources into the body

Abstract

Methods and devices for diagnosing, monitoring, and/or treating tissue through an opening or port through an airway wall. A passageway is created extending from the airway to the target tissue. The passageway provides local access to the target tissue for treatment instruments and for delivering agents.

Claims

1. A method of treating a target tissue in a parenchymal tissue of a lung of a patient, the method comprising:

locating a target site on an airway wall;

creating an opening through the airway wall at the target site;

advancing an elongate instrument through the opening to the target tissue, said elongate instrument comprising an access lumen;

advancing a light delivery instrument through the access lumen and through the opening into the parenchyma to the target tissue in the parenchymal tissue of the lung;

administering a photosensitive drug to the patient; and

directing a beam of light locally at the target tissue, while minimizing collateral damage to surrounding tissue, such that the light activates the photosensitive drug at the target tissue.

2. The method of claim 1 wherein the step of administering is carried out locally to the target tissue.

3. The method of claim 2 wherein the step of administering is carried out by advancing a delivery catheter through the access lumen of the elongate instrument and transporting the photosensitive drug to the target site through the delivery catheter.

4. The method of claim 1 wherein the step of administering is carried out by intravenous injection.

5. The method of claim 1, further comprising dilating the opening with an expandable member.

6. The method of claim 1, wherein advancing the elongate instrument comprises advancing the elongate instrument and a blunt tipped dissecting catheter positioned within the elongate instrument through the opening and to the target tissue.

7. The method of claim 1, further comprising performing imaging to guide the elongate instrument to the target tissue.

8. The method of claim 1, wherein the step of directing the beam of light comprises forming a singlet oxygen molecule by applying a specific wavelength of light to the target tissue, destroying the target tissue from the inside out.

9. The method of claim 1, wherein the elongate instrument is a needle.

10. The method of claim 1, wherein the light delivery instrument is retractable to increase its field of view.

11. The method of claim 1, wherein a lens at the tip of the light instrument is interchangeable for a diffuse beam lens.

12. A method of treating a target tissue within a parenchyma in a lung of a patient, the method comprising:

locating a target site on an airway wall;

creating an opening through the airway wall at the target site;

advancing an elongate instrument through the opening to the target within the parenchyma, said elongate instrument comprising an access lumen;

advancing a delivery catheter through the access lumen;

administering a photosensitive drug to the target tissue through the delivery catheter; and

directing a beam of light to the target tissue while minimizing collateral damage to surrounding tissue, such that the light activates the photosensitive drug at the target tissue within the parenchyma.

13. The method of claim 12 further comprising activating the photosensitive drug to destroy the target tissue.

14. The method of claim 12 further comprising advancing a light delivery instrument through the access lumen to the target tissue.

15. The method of claim 14 wherein activating the photosensitive drug at the target tissue is carried out with the light delivery instrument locally positioned at the target tissue.

16. The method of claim 12 wherein the piercing member comprises an elongate flexible body, a distal section carrying an expandable balloon, and a sharp distal tip.

17. The method of claim 16 further comprising dilating the opening with the balloon.

18. The method of claim 12, wherein the step of directing the narrow beam of light comprises forming a singlet oxygen molecule by applying a specific wavelength of light to the target tissue, destroying the target tissue from the inside out.

19. The method of claim 12, wherein the light delivery instrument is retractable to increase its field of view.

20. The method of claim 12, wherein a lens at the tip of the light instrument is interchangeable for a diffuse beam lens.