Method for modulating a biological activity of a target structure by energy generation in-situ within a medium

• US 10,272,262 B2
• Filed: 01/18/2018
• Issued: 04/30/2019
• Est. Priority Date: 04/04/2008
• Status: Active Grant

• Current Assignee: Immunolight, LLC
• Original Assignee: Immunolight, LLC
• Inventors: Bourke, Jr., Frederic A., Walder, Harold
• Primary Examiner(s): McClendon, Sanza L.
• Application Number:
  US15/874,426
• Publication Number:
  US 20180154171A1
• Time in Patent Office: 467 Days
• Field of Search: None
• CPC Class Codes: A61K 41/0085 Mossbauer effect therapy based on mossbauer effect of a material, i.e. re-emission of gamma rays after absorption of gamma rays by the material; selective radiation therapy, i.e. involving re-emission of ionizing radiation upon exposure to a first ionizing radiation
• CPC Class Codes: A61N 2005/0661 ultraviolet
• CPC Class Codes: A61N 2005/1091 Kilovoltage or orthovoltage range photons
• CPC Class Codes: A61N 2005/1098 Enhancing the effect of the particle by an injected agent or implanted device
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue
• CPC Class Codes: A61N 5/1077 Beam delivery systems

Abstract

A system and method for light stimulation within a medium. Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Claims

1. A method for stimulating electromagnetic energy communication within and/or between cells in a subject, comprising:

non-invasively generating an activation energy in situ in a vicinity of one or more target cells in the subject, wherein the activation energy is electromagnetic energy;

wherein the activation energy directly interacts with the one or more target cells to trigger the one or more target cells to undergo altered metabolic activity, wherein the altered metabolic activity causes electromagnetic energy emissions within and/or from the one or more target cells, to thereby cascade effects of the electromagnetic energy emissions within the one or more target cells and/or to similar or different cell types adjacent thereto.

2. The method of claim 1, further comprising, simultaneously with generating the activation energy, applying an external electromagnetic energy.

3. The method of claim 2, wherein the external electromagnetic energy is microwave energy.

4. The method of claim 1, wherein the activation energy is at least one frequency in a range of from 100 GHz to 10 THz.

5. The method of claim 4, wherein the activation energy is at least one frequency in a range of from 1.5 and 6 THz.

6. The method of claim 1, wherein the electromagnetic energy emissions within and/or from the one or more target cells are at at least one frequency in a range of from 100 GHz to 10 THz.

7. The method of claim 6, wherein the electromagnetic energy emissions within and/or from the one or more target cells are at at least one frequency in a range of from 1.5 and 6 THz.

8. The method of claim 1, further comprising administering to said subject at least one energy modulation agent which adsorbs, intensifies, or modifies an applied initiation energy into the activation energy.

9. The method of claim 8, wherein said at least one energy modulation agent decreases the wavelength of the applied initiation energy.

10. The method of claim 8, wherein said at least one energy modulation agent increases the wavelength of the applied initiation energy.

11. The method of claim 8, wherein the applied initiation energy is UV radiation, visible light, IR radiation, x-rays, gamma rays, a particle beam, microwaves or radio waves.

12. The method of claim 1, wherein the electromagnetic energy is UV radiation, visible light, or IR radiation.

13. The method of claim 1, wherein the electromagnetic energy emissions within and/or from the one or more target cells is UV radiation, visible light, or IR radiation.

14. The method of claim 12, wherein the electromagnetic energy emissions within and/or from the one or more target cells is UV radiation, visible light, or IR radiation.

15. The method of claim 8, wherein the at least one energy modulation agent is one or more members selected from a fluorescing metal nanoparticle, fluorescing metal oxide nanoparticle, fluorescing metal coated metal oxide nanoparticle, fluorescing dye molecule, gold nanoparticle, silver nanoparticle, gold-coated silver nanoparticle, a water soluble quantum dot, a luciferase, a biocompatible phosphorescent molecule, a combined electromagnetic energy harvester molecule, and a lanthanide chelate exhibiting intense luminescence.

16. The method of claim 8, wherein the at least one energy modulation agent comprises a plurality of energy-emitting particles, wherein the generating the activation energy is performed by administration of the plurality of energy-emitting particles in the subject in the vicinity of the one or more target cells and irradiating the plurality of energy-emitting particles by radiating with x-rays from an x-ray source as the applied initiation energy, wherein upon radiation from the x-ray source the plurality of energy-emitting particles radiate the activation energy at a first lower energy than the applied initiation energy to directly interact with the one or more target cells.

17. The method of claim 1, wherein the electromagnetic energy emissions within and/or from the one or more target cells cause at least one of tissue regeneration, inflammation relief, pain relief, immune system fortification, changes in cell membrane permeability, up-regulation and down-regulation of adenosine triphosphate and nitric oxide.

18. The method of claim 1, wherein the effects of the electromagnetic energy emissions cause a mediation, initiation, or enhancement of a biological activity of the target cells and/or the similar or different cells.