Radiopharmaceutical delivery and tube management system

• US 10,272,263 B2
• Filed: 05/20/2016
• Issued: 04/30/2019
• Est. Priority Date: 06/07/2012
• Status: Active Grant

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Bayer Healthcare LLC (Bayer AG)
• Inventors: Hoffman, Raymond C., Tucker, Barry L., Berry, David H., Uram, Martin J., Uber, III, Arthur E., Descalzi, Douglas
• Primary Examiner(s): Mendez, Manuel A
• Application Number:
  US15/160,549
• Publication Number:
  US 20160331998A1
• Time in Patent Office: 1,075 Days
• Field of Search: 604209, 604 19, 60416402
• CPC Class Codes: A61M 39/10 Tube connectors; Tube couplings A61M39/02 takes precedence; connecting needles to syringes or hubs A61M5/34; connecting catheter tubes to hubs A61M25/0014
• CPC Class Codes: A61M 39/20 Closure caps or plugs for connectors or open ends of tubes
• CPC Class Codes: A61M 5/158 Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
• CPC Class Codes: A61M 5/162 Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube in jet-action syringes A61M5/30; connectors for tubes having sealed ends and a needle for piercing them A61M39/14
• CPC Class Codes: A61M 5/1785 comprising radioactive shield means syringe shields or holders for storage of radioactive sources G21F5/018
• CPC Class Codes: A61N 2005/1021 Radioactive fluid
• CPC Class Codes: A61N 2005/1094 Shielding, protecting against radiation
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body

Abstract

A device for delivery of a radiopharmaceutical and, in some embodiments, delivery of a pharmaceutical agent are described herein. Various other components for delivery systems including tubing management systems, primer caps, diffusion chambers, radiation shields and syringe shields, and other devices and methods are also described.

Claims

1. A primer cap comprising:

a tube connector comprising;

a nut configured to be grasped by a user;

a first fitting operably connected to the nut; and

a bore extending from the first fitting though the nut, wherein the bore is designed to operably connect to a tube and to allow fluid flow from the tube through the nut; and

a cap comprising;

a handle designed to be grasped by the user;

a plug insert extending from a surface of the cap opposite the handle, wherein the plug is designed to be inserted into the bore; and

a sealing lip disposed on the plug insert, wherein the sealing lip creates an airtight seal on the bore of the tube connector and facilitate a reversible connection between the cap and the bore.

2. The primer cap of claim 1, further comprising a needle tubing section operably connected to the tube connector and fluidly connected to the bore.

3. The primer cap of claim 2, further comprising a needle operably connected to the needle tubing section opposite the tube connector.

4. The primer cap of claim 2, wherein the tube connector is physically attached to the needle tubing section by one of soldering and gluing.

5. The primer cap of claim 1, further comprising a second fitting extending from the first fitting opposite the first fitting.

6. The primer cap of claim 1, further comprising one or more cantilever tabs surrounding the sealing lip, wherein the one or more cantilever tabs are compressible when the cap is connected to the tube connector.

7. A method for creating a wet-wet connection between tubing sections comprising:

introducing a needle tubing section into a blood vessel of a patient, wherein the needle tubing section comprises;

a tube connector comprising;

a nut configured to be grasped by a user;

a first fitting operably connected to the nut; and

a bore extending from the first fitting though the nut, wherein the bore is configured to operably connect to a tube and to allow fluid flow from the tube through the nut; and

a cap connected to the tube connector, the cap comprising;

a handle configured to be grasped by the user; and

a sealing lip disposed on a surface of the cap opposite the handle, wherein the sealing lip creates an airtight seal on the bore; and

removing the cap from the tube connector such that a vacuum in the tube connector draws blood or other fluids from the patient into the tube; and

connecting a tubing section to the tube connector when the blood or other fluids from the patient fills the tube of the tube connector.

8. The method of claim 7, wherein the sealing lip facilitates a reversible connection between the cap and the bore.

9. The method of claim 7, wherein the needle tubing section further comprises a plug insert extending from the surface of the cap opposite the handle and is configured to be inserted into the bore.

10. The method of claim 7, further comprising one or more cantilever tabs surrounding the sealing lip, wherein the one or more cantilever tabs are compressible when the cap is connected to the tube connector.

11. A method for reducing contamination of a tubing section comprising:

introducing a needle tubing section into a blood vessel of a patient, wherein the needle tubing section comprises;

a diffusion chamber configured to allow a user to monitor diffusion of blood into the needle tubing section;

a first connector at a proximal end of the needle tubing section; and

a second connector at a distal end of the needle tubing section, wherein the second connector is configured to connect to a needle; and

removing the needle tubing section when blood from the patient reaches the first connector.