Urease introduction system for replenishing urease in a sorbent cartridge
First Claim
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1. A dialysis flow loop, comprising:
- a sorbent cartridge containing a urease-binding sorbent material positioned on the flow loop;
a urease compartment positioned upstream of the sorbent cartridge on the flow loop and in fluid communication with the sorbent cartridge, wherein the urease compartment is adapted for receiving one or more of a urease pouch, solid urease, and a removable urease cartridge;
wherein the urease compartment comprises a fluid inlet fluidly connectable to a reservoir and a fluid outlet fluidly connectable to the dialysis flow loop upstream of the sorbent cartridge; and
a control system, the control system programmed to meter at least a portion of urease in the urease compartment into the sorbent cartridge.
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Abstract
An apparatus and method for replenishing urease in a sorbent cartridge for use in sorbent dialysis. The system is configured to allow insertion of a urease pouch, injection of a urease solution, or addition of a urease cartridge, into a dialysis cabinet containing a dialysis flow loop. The urease can be dissolved and the resulting urease solution added to the sorbent cartridge in the flow loop to replenish the urease within the sorbent cartridge. The sorbent cartridge can also comprise other, rechargeable, sorbent materials for removing toxins other than urea from spent dialysate.
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Citations
12 Claims
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1. A dialysis flow loop, comprising:
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a sorbent cartridge containing a urease-binding sorbent material positioned on the flow loop; a urease compartment positioned upstream of the sorbent cartridge on the flow loop and in fluid communication with the sorbent cartridge, wherein the urease compartment is adapted for receiving one or more of a urease pouch, solid urease, and a removable urease cartridge; wherein the urease compartment comprises a fluid inlet fluidly connectable to a reservoir and a fluid outlet fluidly connectable to the dialysis flow loop upstream of the sorbent cartridge; and a control system, the control system programmed to meter at least a portion of urease in the urease compartment into the sorbent cartridge. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification