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Urease introduction system for replenishing urease in a sorbent cartridge

  • US 10,272,363 B2
  • Filed: 03/09/2015
  • Issued: 04/30/2019
  • Est. Priority Date: 06/24/2014
  • Status: Active Grant
First Claim
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1. A dialysis flow loop, comprising:

  • a sorbent cartridge containing a urease-binding sorbent material positioned on the flow loop;

    a urease compartment positioned upstream of the sorbent cartridge on the flow loop and in fluid communication with the sorbent cartridge, wherein the urease compartment is adapted for receiving one or more of a urease pouch, solid urease, and a removable urease cartridge;

    wherein the urease compartment comprises a fluid inlet fluidly connectable to a reservoir and a fluid outlet fluidly connectable to the dialysis flow loop upstream of the sorbent cartridge; and

    a control system, the control system programmed to meter at least a portion of urease in the urease compartment into the sorbent cartridge.

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