Formulation for the treatment of acne

• US 10,278,945 B2
• Filed: 08/25/2016
• Issued: 05/07/2019
• Est. Priority Date: 08/28/2015
• Status: Active Grant

• Current Assignee: Nouryon Chemicals International B.V. (Nouryon BV)
• Original Assignee: Akzo Nobel Chemicals International B.V. (Nouryon BV)
• Inventors: Opsahl, Ross Christian, Butuc, Steluta Gina
• Primary Examiner(s): Puttlitz, Karl J
• Application Number:
  US15/755,586
• Publication Number:
  US 20190022050A1
• Time in Patent Office: 985 Days
• Field of Search: None
• CPC Class Codes: A61K 31/327 Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
• CPC Class Codes: A61K 47/08 containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61K 9/10 Dispersions; Emulsions A61K9/06 takes precedence; composition of dispersions, emulsions A61K47/00
• CPC Class Codes: A61P 17/10 Anti-acne agents

Abstract

Peroxide of the formula wherein R¹ is selected from linear and branched alkyl groups with 1-4 carbon atoms, and R², R³, and R⁴ are selected from hydrogen and linear and branched alkyl groups with 1-4 carbon atoms, for use as a medicament, in particular for the treatment of acne.

Claims

1. A method of treatment of acne comprising topical application to skin of an effective amount of peroxide of the formula

2. The method of claim 1 wherein R¹ and R² are selected from methyl, tert-butyl, and n-butyl groups.

3. The method of claim 1 wherein R³ and R⁴ are both hydrogen.

4. The method of claim 3 wherein R¹ and R² are positioned at the para position.

5. The method of claim 1 wherein the peroxide is di(4-methylbenzoyl)peroxide.

6. A method of inhibiting the proliferation of Staphylococcus aureus, Staphylococcus epidermidis, and/or Propionibacerium acnes to a subject in need thereof;

comprising the topical application of an effective amount of a peroxide with the formula

7. The method of claim 6 wherein the peroxide is di(4-methylbenzoyl)peroxide.