Composite grafts, systems, and methods
First Claim
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1. A composite graft, comprising:
- a biocompatible, synthetic scaffold; and
a biological tissue component obtained or derived from a deceased donor tissue, wherein the biological tissue component is embedded in the biocompatible, synthetic scaffold, wherein;
the composite graft is porous or has one or more porous regions,the biological tissue component comprises bone particles, cartilage particles, or collagen particles,the biological tissue component comprises particles having an average diameter from 0.01 mm to 5 mm, andthe particles are embedded in the biocompatible, synthetic scaffold, andthe composite graft is formed by;
combining the biological tissue component with a curing solution to form a composite mixture, the curing solution comprising at least one polymerizing agent,disposing the composite mixture into a mold, andcuring the composite mixture for a predetermined period of time at a predetermined temperature to form the composite graft, the predetermined period of time at a predetermined temperature being sufficient to cause the polymerizing agent to polymerize into the biocompatible, synthetic scaffold, wherein the polymerizing agent, when solidified, has a durometer in the range of between 10 and 65.
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Abstract
Composite grafts including a biocompatible, synthetic scaffold; and a biological tissue component obtained or derived from a deceased donor tissue, wherein the biological tissue component is embedded in the biocompatible, synthetic scaffold, are provided as systems relating thereto. Methods of manufacture and methods of treatment using such grafts are also provided.
23 Citations
17 Claims
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1. A composite graft, comprising:
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a biocompatible, synthetic scaffold; and a biological tissue component obtained or derived from a deceased donor tissue, wherein the biological tissue component is embedded in the biocompatible, synthetic scaffold, wherein; the composite graft is porous or has one or more porous regions, the biological tissue component comprises bone particles, cartilage particles, or collagen particles, the biological tissue component comprises particles having an average diameter from 0.01 mm to 5 mm, and the particles are embedded in the biocompatible, synthetic scaffold, and the composite graft is formed by; combining the biological tissue component with a curing solution to form a composite mixture, the curing solution comprising at least one polymerizing agent, disposing the composite mixture into a mold, and curing the composite mixture for a predetermined period of time at a predetermined temperature to form the composite graft, the predetermined period of time at a predetermined temperature being sufficient to cause the polymerizing agent to polymerize into the biocompatible, synthetic scaffold, wherein the polymerizing agent, when solidified, has a durometer in the range of between 10 and 65. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification