Devices and methods for modulating medium delivery

• US 10,279,104 B2
• Filed: 03/17/2015
• Issued: 05/07/2019
• Est. Priority Date: 08/28/2012
• Status: Active Grant

• Current Assignee: Osprey Medical, Inc.
• Original Assignee: Osprey Medical, Inc.
• Inventors: Burns, Matthew M., Doan, Tuan M., Houfburg, Rodney L., Kaye, David M., Mans, Daniel R., Mortier, Todd J.
• Primary Examiner(s): Osinski, Bradley J
• Assistant Examiner(s): Shah, Nilay J
• Application Number:
  US14/660,410
• Publication Number:
  US 20150265761A1
• Time in Patent Office: 1,512 Days
• CPC Class Codes: A61M 2025/0076 Unidirectional valves
• CPC Class Codes: A61M 2039/2413 designed to reduce and or shut-off the flow when a certain maximum flow limit is exceeded
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3337 Controlling, regulating pressure or flow by means of a valve by-passing a pump
• CPC Class Codes: A61M 2205/3341 stabilising pressure or flow to avoid excessive variation
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/3355 Controlling downstream pump pressure
• CPC Class Codes: A61M 2206/22 eliminating pulsatile flows, e.g. by the provision of a dampening chamber
• CPC Class Codes: A61M 2210/125 Heart
• CPC Class Codes: A61M 2210/127 Aorta
• CPC Class Codes: A61M 25/0075 Valve means
• CPC Class Codes: A61M 39/24 Check- or non-return valves
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/1413 Modular systems comprising interconnecting elements
• CPC Class Codes: A61M 5/14212 Pumping with an aspiration and an expulsion action
• CPC Class Codes: A61M 5/14216 Reciprocating piston type
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/16881 Regulating valves on-off valves, e.g. clamps A61M39/28
• CPC Class Codes: A61M 5/48 having means for varying, regulating, indicating or limiting injection pressure A61M5/142 takes precedence ; monitoring pressure in infusion systems A61M5/16854
• CPC Class Codes: A61M 5/482 : Varying injection pressure, e.g. by varying speed of injection
• CPC Class Codes: A61M 5/484 : Regulating injection pressure
• CPC Class Codes: A61M 5/488 : Limiting injection pressure
• CPC Class Codes: F04B 11/0033 : with a mechanical spring
• CPC Class Codes: G16H 20/10 : relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection

Abstract

Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.

Claims

1. A system to control, regulate, alter, transform or otherwise modulate fluid delivery of a medium injected to a delivery site of a patient'"'"'s body, comprising:

a sterile medium container that contains the medium;

a syringe for injecting the medium;

a delivery catheter comprising a conduit and providing for a fluid flow pathway for delivering the medium from the syringe to the delivery site of the patient'"'"'s body at a desired flow rate;

a mechanical modulator disposed between the syringe and the delivery catheter, wherein the mechanical modulator is constructed to function simultaneously with an injection by the syringe, the mechanical modulator comprising;

a medium reservoir, the medium reservoir including a chamber for receiving the medium therein when a flow rate of the injection is greater than the desired flow rate, and the medium reservoir including at least one surface within the chamber capable of imparting a force on the medium within the chamber;

a first connector having a lumen therethrough, wherein the first connector lumen includes a first medium port fluidly coupled to the syringe, a second medium port fluidly coupled to the chamber of the medium reservoir and operably coupled to a first valve, and a third medium port fluidly coupled to a second connector; and

the second connector comprising a second valve and providing fluid communication between the sterile medium container and the fluid flow pathway, wherein the second connector resides between the first connector and the delivery catheter;

wherein in a first configuration of the system to allow filling of the syringe with medium from the sterile medium container, the first valve is closed and the second valve is open so as to allow medium to flow in a first direction through the first connector from the third port to the first port; and

wherein in a second configuration of the system to allow ejection of the medium from the syringe to the delivery catheter and to the mechanical modulator, the first valve is open and the second valve is closed, to allow medium to flow in a second, opposite direction through the first connector from the first port to the third port.

2. The system of claim 1 wherein the force is imparted such that the medium in the chamber is subjected to a pressure force that establishes a predetermined maximum pressure value for the medium in the system.

3. The system of claim 1 wherein the second connector is a manifold.

4. The system of claim 1 wherein the desired flow rate is a function of force applied to the medium in the system by the syringe and by the medium reservoir.

5. The system of claim 1 wherein the medium has a predetermined maximum pressure value.

6. The system of claim 1 wherein a fluid characteristic of the medium in the delivery catheter is affected by the mechanical modulator while the medium flows from the syringe to the delivery catheter.

7. The system of claim 1 wherein the medium reservoir further comprises a weight disposed relative to the at least one surface within the chamber to urge the surface against the medium within the chamber.

8. The system of claim 1 wherein the medium reservoir further comprises a spring disposed relative to the at least one surface within the chamber to urge the surface against the medium within the chamber.

9. The system of claim 1 wherein the medium reservoir functions as a capacitive pressure reservoir for the medium in the system, either accepting the medium from the syringe or discharging the medium into the delivery catheter, at least during medium flow throughout the system.

10. The system of claim 1 wherein the mechanical modulator further comprises a third valve disposed between the second connector and the delivery catheter, said third valve capable of ceasing the fluid delivery when a minimal pressure is not maintained.

11. The system of claim 10 wherein the third valve is a one-way valve.