Dose setting mechanism for priming a drug delivery device

• US 10,279,116 B2
• Filed: 03/20/2013
• Issued: 05/07/2019
• Est. Priority Date: 06/01/2009
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Plumptre, David Aubrey, Jones, Christopher John, Veasey, Roberts Frederick
• Primary Examiner(s): Mehta, Bhisma
• Assistant Examiner(s): Frehe, William R
• Application Number:
  US13/847,866
• Publication Number:
  US 20130218130A1
• Time in Patent Office: 2,239 Days
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 2005/2492 via snap connection
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 2005/3126 Specific display means related to dosing
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: A61M 5/31536 Blocking means to immobilize a selected dose, e.g. to administer equal doses
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31561 using freely adjustable volume steps
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: A61M 5/347 rotatable, e.g. bayonet or screw A61M5/344 takes precedence
• CPC Class Codes: A61M 5/348 snap lock, i.e. upon axial displacement of needle assembly A61M5/344 takes precedence

Abstract

A method and system for priming a drug delivery device. The drug delivery device includes a dose dial sleeve and an internal housing portion. The dose dial sleeve is coupled to the internal housing. The dose dial sleeve rotates on a substantially circumferential rotational path during priming of the drug delivery device. Further, the dose dial sleeve rotates on a helical path during dose setting of the drug delivery device.

Claims

1. A method of priming a drug delivery device, the method comprising the steps of:

engaging a dose dial sleeve with an inner housing of the drug delivery device, wherein the dose dial sleeve surrounds the inner housing; and

priming the drug delivery device by rotating the dose dial sleeve on a substantially circumferential rotational path around the inner housing,

wherein, when a needle is coupled to the drug delivery device, the priming, which occurs during the rotation of the dose dial sleeve, causes a small amount of a drug to be expelled from the drug delivery device.

2. The method of claim 1, further comprising:

responsive to the priming of the drug delivery device, preventing the dose dial sleeve from rotating circumferentially back along the substantially circumferential rotational path that the dose dial sleeve traveled during the priming.

3. The method of claim 2, wherein the dose dial sleeve comprises at least one non-return feature,

wherein the inner housing comprises at least one corresponding non-return feature, and

wherein preventing the dose dial sleeve from rotating circumferentially comprises the at least one non-return feature of the dose dial sleeve interacting with the at least one corresponding non-return feature of the inner housing.

4. The method of claim 3, wherein the inner housing comprises a substantially circumferential rotational thread, and

wherein rotating the dose dial sleeve on the substantially circumferential rotational path around the inner housing comprises rotating the dose dial sleeve along the substantially circumferential rotational thread.

5. The method of claim 1 further comprising setting a dose of the drug by translating the dose dial sleeve along a helical path.

6. The method of claim 1, wherein the inner housing comprises a threaded portion.

7. The method of claim 6, wherein the threaded portion comprises a rotational threaded portion and a helical threaded portion.

8. The method of claim 7, wherein priming the drug delivery device by rotating the dose dial sleeve on the substantially circumferential rotational path around the inner housing comprises rotating the dose dial sleeve on the rotational threaded portion.

9. The method of claim 8, further comprising setting a dose of the drug by translating the dose dial sleeve along the helical threaded portion.

10. The method of claim 7, further comprising preventing the dose dial sleeve from rotating on the helical threaded portion prior to the priming of the delivery device.

11. The method of claim 1, wherein the dose dial sleeve comprises at least one non-return element.

12. The method of claim 11, wherein the inner housing comprises at least one complimentary non-return element that is complimentary to the at least one non-return element of the dose dial sleeve.

13. The method of claim 12, wherein the at least one non-return element comprises at least one protrusion from the dose dial sleeve, and

wherein the at least one complimentary non-return element comprises at least one protrusion from the inner housing.

14. The method of claim 13, wherein the at least one non-return element is connected to a flexible element portion of the dose dial sleeve,

wherein the flexible element portion allows for the at least one non-return element to pass over the at least one complimentary non-return element during the rotation of the dose dial sleeve, and

wherein, at the end of the substantially circumferential rotational path, the flexible element portion operates to prevent the at least one non-return element from passing back over the at least one complimentary non-return element.

15. The method of claim 12, wherein, when the dose dial sleeve substantially reaches an end of the substantially circumferential rotational path, the at least one non-return element and the at least one complimentary non-return element interact to prevent substantial movement of the dose dial sleeve back along the substantially circumferential rotational path.

16. The method of claim 1, wherein a dose setting mechanism of the drug delivery device comprises the dose dial sleeve and the inner housing, and wherein the method further comprises coupling the dose setting mechanism and a cartridge housing.

17. The method of claim 16, wherein coupling the dose setting mechanism and the cartridge housing comprises non-reversibly coupling the dose setting mechanism and the cartridge housing.

18. The method of claim 1, further comprising displaying a graphic disposed on the dose dial sleeve prior to the priming of the delivery device, wherein the display of the graphic indicates that the delivery device has not been primed.

19. The method of claim 1, wherein a dose setting mechanism of the drug delivery device comprises:

the dose dial sleeve;

the inner housing;

a driver; and

a spindle,

wherein the dose dial sleeve is operatively coupled to the driver such that rotation of the dose dial sleeve causes the driver to rotate and the spindle to translate in a distal direction, and

wherein the translation of the spindle causes the priming of the drug delivery device.

20. The method of claim 1, wherein the dose dial sleeve comprises at least one non-return element;

wherein the inner housing comprises at least one complimentary non-return element that is complimentary to the at least one non-return element of the dose dial sleeve,

wherein, when a user is setting a dose, the at least one non-return element and the at least one complimentary non-return element prevent substantial rotational movement along the substantially circumferential rotational path, and

wherein, when the user is not setting a dose, the at least one non-return element and the at least one complimentary non-return element are capable of being overcome by a user of the device.