System for selective spatiotemporal stimulation of the spinal cord

• US 10,279,177 B2
• Filed: 08/04/2017
• Issued: 05/07/2019
• Est. Priority Date: 12/22/2015
• Status: Active Grant

• Current Assignee: Ecole polytechnique fãdãrale de lausanne epfl (Schweizerische Eidgenossenschaft)
• Original Assignee: Ecole polytechnique fãdãrale de lausanne epfl (Schweizerische Eidgenossenschaft)
• Inventors: Bloch, Jocelyne, Courtine, Gregoire, Wenger, Nikolaus, Micera, Silvestro, Capogrosso, Marco
• Primary Examiner(s): Wehrheim, Lindsey G
• Application Number:
  US15/669,208
• Publication Number:
  US 20170354819A1
• Time in Patent Office: 641 Days
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36139 with automatic adjustment

Abstract

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.

Claims

1. A system for neuromodulation of a nervous system of a subject, comprising:

a pulse generator configured to simultaneously deliver independent current or voltage pulses to more than one electrode, wherein the more than one electrodes are configured to cover a portion of the spinal cord to selectively stimulate specific dorsal roots, wherein said pulse generator is operatively connected with the more than one electrodes to provide spatiotemporal stimulation of the portion of the spinal cord, wherein the more than one electrodes are part of a multi-electrode array comprising at least a portion comprising electrodes arranged in a direction transverse relative to the portion of the spinal cord and at least one portion comprising electrodes arranged in a longitudinal direction relative to the portion of the spinal cord.

2. The system according to claim 1, wherein neuromodulation of the nervous system of the subject further comprises neurostimulation of the spinal cord of the subject.

3. The system according to claim 1, wherein the more than one electrodes are configured to selectively stimulate single dorsal roots.

4. The system according to claim 1, wherein the pulse generator is operatively connected with the more than one electrodes to provide a multipolar stimulation.

5. The system according to claim 4, wherein the multipolar stimulation is configured to modulate a shape of a stimulating field in order to increase a spatial specificity of the multipolar stimulation.

6. The system according to claim 1, wherein the portion comprising electrodes arranged in the direction transverse relative to the spinal cord and the at least one portion comprising electrodes arranged in the longitudinal direction relative to the spinal cord are alternately disposed in the multi-electrode array.

7. The system according to claim 1, wherein the portion comprising electrodes arranged in the direction transverse relative to the spinal cord engages the spinal cord in a ring configuration.

8. The system of claim 7, wherein the selective stimulation of specific dorsal roots includes selective stimulation of lumbar spinal roots.

9. The system according to claim 1, wherein the portion comprising electrodes arranged in the longitudinal direction includes electrodes arranged in two or more columns disposed in the longitudinal direction.

10. The system of claim 9, wherein the selective stimulation of specific dorsal roots includes selective stimulation of cervical and/or sacral spinal roots.

11. The system of claim 1, wherein the selective stimulation of specific dorsal roots promotes a specific movement of a limb.

12. A method for neuromodulation of a nervous system of a subject, comprising:

a) providing a pulse generator configured to simultaneously deliver independent current or voltage pulses to more than one electrode;

b) providing the more than one electrodes configured to cover a portion of the spinal cord to selectively stimulate specific dorsal roots, wherein said pulse generator is operatively connected with the more than one electrodes to provide stimulation; and

c) providing spatiotemporal neuromodulation to the subject, wherein the more than one electrodes are part of a multi-electrode array comprising at least a portion comprising electrodes arranged in a direction transverse relative to the portion of the spinal cord and at least one portion comprising electrodes arranged in a longitudinal direction relative to the spinal cord.

13. The method of claim 12, wherein neuromodulation of the nervous system of the subject further comprises neurostimulation of the spinal cord of the subject.

14. The method according to claim 12, wherein the neuromodulation is a multipolar stimulation.

15. The method according to claim 14, wherein the multipolar stimulation further comprises modulating a shape of a stimulating field to increase the spatial selectivity of the multipolar stimulation.

16. The method according to claim 14, wherein the multipolar stir further comprises selective stimulation of single dorsal roots.

17. The method according to claim 12, wherein the portion comprising electrodes arranged in the direction transverse relative to the spinal cord and the at least one portion comprising electrodes arranged in the longitudinal direction relative to the spinal cord are alternately disposed in the multi-electrode array.

18. The method according to claim 12, wherein the portion comprising electrodes arranged in the direction transverse relative to the spinal cord engages the spinal cord in a ring configuration.

19. The method according to claim 12, wherein the portion comprising electrodes arranged in the longitudinal direction includes electrodes arranged in two or more columns disposed in the longitudinal direction.

20. The method of claim 12, wherein the selective stimulation of specific dorsal roots promotes an induction of specific muscle responses.