Method of magnetic resonance with excitation by a prewinding pulse

• US 10,281,548 B2
• Filed: 03/06/2014
• Issued: 05/07/2019
• Est. Priority Date: 03/27/2013
• Status: Active Grant

• Current Assignee: Universitätsklinikum Freiburg
• Original Assignee: Universitätsklinikum Freiburg
• Inventors: Asslaender, Jakob, Hennig, Juergen, Glaser, Steffen
• Primary Examiner(s): Hollington, Jermele M
• Application Number:
  US14/652,129
• Publication Number:
  US 20150323631A1
• Time in Patent Office: 1,888 Days
• Field of Search: None
• CPC Class Codes: G01R 33/4616 using specific RF pulses or specific modulation schemes, e.g. stochastic excitation, adiabatic RF pulses, composite pulses, binomial pulses, Shinnar-le-Roux pulses, spectrally selective pulses not being used for spatial selection
• CPC Class Codes: G01R 33/50 based on the determination of relaxation times , e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences
• CPC Class Codes: G01R 33/561 by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences

Abstract

A method of magnetic resonance, in which a sample introduced in a measurement volume in an external magnetic field is excited by an excitation pulse and the signal formed by the transverse magnetization thus produced is read out by a receiving coil. The method is characterized in that a prewinding pulse is used as the excitation pulse, which prewinding pulse is characterized in that the formed transverse magnetization M_⊥(ω) of spins of different Larmor frequency ω after the pulse has a phase φ₀(ω), wherein φ₀(ω) as a function of ω within a predefined frequency range Δω has an approximately linear course having negative slope, such that the spins refocus after an echo time defined by the pulse without an additional refocusing pulse being necessary.

Claims

1. A method of magnetic resonance for examination of a sample introduced into a measurement volume within an external magnetic field, the method comprising the steps of:

a) exciting the sample using an excitation pulse, wherein the excitation pulse is a prewinding pulse generating a transverse magnetization M_⊥

(ω

) of spins of different Larmor frequency ω

after the excitation pulse, the transverse magnetization having a phase φ

₀(ω

), wherein φ

₀(ω

), as a function of ω

within a predefined frequency range Δ

ω

, has an approximately linear course with negative slope, such that spins refocus to form a spin echo after an end of the excitation pulse at an echo time, wherein the echo time is defined by the excitation pulse and is larger than the duration of the excitation pulse, with no additional refocusing pulse or refocusing gradient thereby being necessary; and

b) reading out, after a time interval and using a receiving coil, a signal formed by the transverse magnetization produced in step a).

2. The method of claim 1, wherein a time profile of an amplitude and a phase of the prewinding pulse is calculated by solving Bloch equations inversely and the prewinding pulse is produced accordingly.

3. The method of claim 1, wherein the prewinding pulse is calculated using a Shinnar-Le Roux method.

4. The method of claim 1, wherein the prewinding pulse is calculated by an optimal control method.

5. The method of claim 1, wherein the signal is read out spatially encoded in 1, 2, or 3 dimensions by means of time-variable magnetic field gradients, wherein a spatial encoding is performed using at least one of a conventional method, Fourier encoding, radial imaging and spiral imaging.

6. The method of claim 1, wherein the signal is read out after a delay, thereby undergoing a defined, freely selectable T2*-dependent modulation of amplitude and/or phase.

7. The method of claim 5, wherein a produced signal is refocused and read out one or more times at incremental readout times using single or multiple gradient inversion.

8. The method of claim 6, wherein a produced signal is refocused and read out one or more times at incremental readout times using single or multiple gradient inversion.

9. The method of claim 1, wherein the prewinding pulse is applied under a slice selection gradient of strength Amp, wherein the slice selection gradient is switched off after an end of the prewinding pulse and in such a manner that a time integral under the gradient corresponds to an action integral Amp*TE required for self-refocusing.

10. The method of claim 9, wherein a formed signal is read out under a readout gradient GR.

11. The method of claim 1, wherein both the prewinding pulse and the signal occur under a spatially encoded gradient GR.

12. The method of claim 11, wherein repetition of acquisition is carried out in a spatial direction other than 2 or 3-dimensional radial spatial encoding.

13. The method of claim 11, wherein repetition of acquisition is performed with different phase encoding steps between excitation and data readout.

14. The method of claim 9, wherein the prewinding pulse is switched under a time-variable gradient.

15. The method of claim 14, wherein the prewinding pulse is used under a time-variable gradient according to a VERSE method.

16. The method of claim 1, wherein the excitation pulse is chosen to initially take the magnetization to flip angles defined by α

_z<

α

(t)<

n−

α

_z.

17. The method of claim 1, wherein the excitation pulse is chosen such that, with a limited maximum pulse amplitude, Rmax(α

)<

Rmax(90°

) is achieved with a negative sign.

18. The method of claim 1, wherein the excitation pulse is chosen to have a constant amplitude and one or more phase jumps.

19. The method of claim 1, wherein an amplitude of the excitation pulse is shaped and changes sign at one or more points.