Spin relaxometry based molecular sequencing
First Claim
Patent Images
1. A method for detecting a target molecule comprising:
- allowing a fluid containing the target molecule to pass by a complementary moiety attached to a paramagnetic ion so as to cause the complementary moiety and the paramagnetic ion to change a position;
detecting a magnetic effect change caused by the change in position of the paramagnetic ion comprising detecting a change in spin relaxation of an electron spin center; and
identifying the target molecule based on the identity of the complementary moiety and the detected magnetic effect change.
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Abstract
A method and system for detecting a target molecule. The method includes allowing a fluid containing the target molecule to pass by a complementary moiety attached to a paramagnetic ion so as to cause the complementary moiety and the paramagnetic ion to change a position. A magnetic effect change caused by the change in position of the paramagnetic ion is detected. The target molecule is identified based on the identity of the complementary moiety and the detected magnetic effect change.
423 Citations
36 Claims
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1. A method for detecting a target molecule comprising:
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allowing a fluid containing the target molecule to pass by a complementary moiety attached to a paramagnetic ion so as to cause the complementary moiety and the paramagnetic ion to change a position; detecting a magnetic effect change caused by the change in position of the paramagnetic ion comprising detecting a change in spin relaxation of an electron spin center; and identifying the target molecule based on the identity of the complementary moiety and the detected magnetic effect change. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for detecting target moieties of a target molecule comprising:
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allowing a fluid containing the target molecule to pass by a plurality of complementary moieties, each of the plurality of complementary moieties attached to a different respective paramagnetic ion and specific to a respective of the target moieties, so as to cause a respective complementary moiety and paramagnetic ion to change a position; detecting a magnetic effect change caused by the change in position of a respective of the paramagnetic ions for each of the plurality of target moieties comprising detecting a change in spin relaxation of an electron spin center; and identifying the target moieties based on the identities of the complementary moieties and the detected magnetic effect changes. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A system for detecting a target molecule comprising:
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a substrate comprising an electron spin center; a complementary moiety attached to a paramagnetic ion, which is attached to the substrate; a magnetic effect detector arranged to detect a magnetic effect change of the electron spin center caused by a change in position of the paramagnetic ion due to the target molecule passing by the complementary moiety; and a processor configured to identify the target molecule based on the identity of the complementary moiety and the detected magnetic effect change. - View Dependent Claims (23, 24, 25, 26, 27, 28)
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29. A system for detecting target moieties of a target molecule comprising:
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a substrate comprising a plurality of electron spin centers; a plurality of complementary moieties attached to respective of a plurality of paramagnetic ions, which are attached to the substrate, each of the plurality of complementary moieties attached to a different respective paramagnetic ion and specific to a respective of the target moieties; a magnetic effect detector arranged to detect, for each of the target moieties, a magnetic effect change of a respective electron spin center caused by a change in position of a respective of the paramagnetic ions due to the target moieties passing by a respective of the complementary moieties; and a processor configured to identify the target moieties based on the identities of the complementary moieties and detected magnetic effect changes. - View Dependent Claims (30, 31, 32, 33, 34, 35)
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36. A method for detecting target moieties of a target molecule comprising:
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allowing a fluid containing the target molecule to pass by a plurality of complementary moieties, each of the plurality of target moieties attached to a different respective paramagnetic ion and specific to a respective of the complementary moieties, so as to cause a respective target moiety and paramagnetic ion to change a position; detecting a magnetic effect change caused by the change in position of a respective of the paramagnetic ions for each of the plurality of target moieties comprising detecting a change in spin relaxation of an electron spin center; and identifying the target moieties based on the identities of the complementary moieties and the detected magnetic effect changes.
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Specification