Self indicating antimicrobial chemistry

• US 10,285,401 B2
• Filed: 09/09/2016
• Issued: 05/14/2019
• Est. Priority Date: 09/10/2015
• Status: Active Grant

• Current Assignee: Ecolab USA Incorporated (Ecolab, Inc.)
• Original Assignee: Ecolab USA Incorporated (Ecolab, Inc.)
• Inventors: McSherry, David D., Li, Junzhong, Staub, Richard
• Primary Examiner(s): Palenik, Jeffrey T.
• Application Number:
  US15/260,760
• Publication Number:
  US 20170071200A1
• Time in Patent Office: 977 Days
• Field of Search: None
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 37/16 containing the group; Thio analogues thereof
• CPC Class Codes: C12Q 1/18 Testing for antimicrobial activity of a material
• CPC Class Codes: C12Q 1/22 Testing for sterility conditions
• CPC Class Codes: C12Q 1/28 involving peroxidase
• CPC Class Codes: C12Y 111/01007 Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
• CPC Class Codes: G01N 2333/908 acting on hydrogen peroxide as acceptor (1.11)

Abstract

Self-indicating chemistries are provided for visual detection by a user of efficacious levels of peroxycarboxylic acid concentrations in a solution produced in situ. The self-indicating chemistries include a combination of dyes providing a visual color indication, such as a tri-color indicator system, such as a yellow, green, and red color system indicating in situ threshold levels of peroxycarboxylic acid concentrations in a solution employing the self-indicating chemistry. Systems, kits and compositions for a quantitative assessment of an in situ perhydrolysis reaction to generate peroxycarboxylic acids are provided. Methods of use are further provided.

Claims

1. A self-indicating peroxycarboxylic acid chemistry composition comprising:

a peroxycarboxylic acid;

a background dye comprising FD&

C Blue No. 1;

at least one latent peracid-selective dye, wherein said at least one peracid-selective dye is a horseradish peroxidase (HRP) substrate, which upon oxidation by the peroxycarboxylic acid, provides a visual indication of the presence of a minimum concentration of peroxycarboxylic acid for efficacy as an antimicrobial; and

wherein the composition is free of iodide.

2. The composition of claim 1, wherein the combination of dyes have different half-lives to provide sustained visual indication of peroxycarboxylic acid concentration for at least 12 hours.

3. The composition of claim 1, wherein the HRP substrate is p-Nitrophenyl Phosphate, Disodium Salt, 2,2″

-Azinobis [3-ethylbenzothiazoline-6-sulfonic acid]-diammonium salt, o-phenylenediamine dihydrochloride, 3,3′

,5,5′

-tetramethylbenzidine, or combinations thereof.

4. The composition of claim 1, wherein the background dye is produced using aromatic hydrocarbons from petroleum.

5. The composition of claim 1, wherein the latent dye is non-destructive to the peroxycarboxylic acid and/or provides at least about 10% improvement in peroxycarboxylic acid stabilization in comparison to a peroxycarboxylic acid composition not employing the dye as measured by concentration (ppm) of the peroxycarboxylic acid retained in the composition over at least 10 minutes.

6. The composition of claim 1, wherein the peroxycarboxylic acid is a C1-C18 peroxycarboxylic acid.

7. The composition of claim 1, wherein the latent dyes provide a tri-color indicator system.

8. The composition of claim 1, further comprising at least one additional functional ingredient selected from the group consisting of a catalyst, stabilizing agent, pH buffering agent, acidulant, defoaming agent, anti-redeposition agent, bleaching agent, solubility modifier, dispersant, wetting agent, metal protecting agent, corrosion inhibitor, additional sequestrant and/or chelating agent, fragrance, dye, rheology modifier or thickener, hydrotrope or coupler, solvent and combinations thereof.