Interframe energy normalization in an optoacoustic imaging system
First Claim
1. An optoacoustic imaging system comprising:
- a light subsystem having a first and a second light source the first light source configured to generate at least one pulse of light at a first predominant wavelength and the second light source configured to generate at least one pulse of light at a second predominant wavelength;
a probe having a distal end and a proximal end, the probe comprising;
i) ultrasound transducer array having an active end located at the distal end of the handheld probe, the ultrasound transducer array capable of receiving an optoacoustic return signal; and
ii) optical window located at the distal end of the probe;
light path adapted to direct light from the first and second light sources to the optical window of the probe and a volume of tissue;
at least one sensor adapted to measure a portion of the light transmitted along the light path;
data acquisition subsystem adapted to sample the ultrasound transducer array for optoacoustic return signals from the volume of tissue during a predetermined period of time after a first pulse of light from the first light source and during a predetermined period of time after a second pulse of light from the second light source and to store sampled data associated with the optoacoustic return signals;
image processing subsystem adapted to reconstruct a first optoacoustic image based on the sampled data corresponding to the first pulse of light from the first light source and to reconstruct a second optoacoustic image based on the sampled data corresponding to the second pulse of light from the second light source;
energy normalizing subsystem adapted to compute a normalization factor based on a measurement from the at least one sensor and to apply the normalization factor to at least one of the sampled data, the first optoacoustic image or the second optoacoustic image, wherein the normalization factor is based upon normalizing energy deviation of the first and second pulses of light with respect to a calibrated reference level for each of the first and second light sources; and
display for outputting at least one reconstructed optoacoustic image.
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Abstract
An optoacoustic imaging system includes a handheld probe and first and second pulsed light sources having a common output. The first and second light sources generate pulses of light at first and second predominant wavelengths, respectively. The handheld probe includes an ultrasound transducer array having an active end located at the distal end of the handheld probe for receiving an optoacoustic return signal. A sensor measures a portion of the light transmitted along the light path. A data acquisition samples the ultrasound transducer array during a predetermined period of time after a pulse of light from the first light source and during a predetermined period of time after a pulse of light from the second light source. The sampled data is stored. An image processing unit reconstructs a first optoacoustic image based on the sampled data corresponding to a pulse of light from the first light source and reconstructs a second optoacoustic image based on the sampled data corresponding to a pulse of light from the second light source. An energy normalizing unit computes a normalization factor based on a measurement from each sensor in the array and applies the normalization factor to data corresponding to the pulse of light.
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Citations
25 Claims
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1. An optoacoustic imaging system comprising:
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a light subsystem having a first and a second light source the first light source configured to generate at least one pulse of light at a first predominant wavelength and the second light source configured to generate at least one pulse of light at a second predominant wavelength; a probe having a distal end and a proximal end, the probe comprising; i) ultrasound transducer array having an active end located at the distal end of the handheld probe, the ultrasound transducer array capable of receiving an optoacoustic return signal; and ii) optical window located at the distal end of the probe; light path adapted to direct light from the first and second light sources to the optical window of the probe and a volume of tissue; at least one sensor adapted to measure a portion of the light transmitted along the light path; data acquisition subsystem adapted to sample the ultrasound transducer array for optoacoustic return signals from the volume of tissue during a predetermined period of time after a first pulse of light from the first light source and during a predetermined period of time after a second pulse of light from the second light source and to store sampled data associated with the optoacoustic return signals; image processing subsystem adapted to reconstruct a first optoacoustic image based on the sampled data corresponding to the first pulse of light from the first light source and to reconstruct a second optoacoustic image based on the sampled data corresponding to the second pulse of light from the second light source; energy normalizing subsystem adapted to compute a normalization factor based on a measurement from the at least one sensor and to apply the normalization factor to at least one of the sampled data, the first optoacoustic image or the second optoacoustic image, wherein the normalization factor is based upon normalizing energy deviation of the first and second pulses of light with respect to a calibrated reference level for each of the first and second light sources; and display for outputting at least one reconstructed optoacoustic image. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 19, 20, 23)
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10. An optoacoustic imaging system comprising:
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a light subsystem having a first and a second light source, the first light source configured to generate at least one pulse of light at a first predominant wavelength and the second light source configured to generate at least one pulse of light at a second predominant wavelength; a probe having a distal end and a proximal end, the probe comprising; ultrasound transducer array having an active end located at the distal end of the handheld probe, the ultrasound transducer array capable of receiving an optoacoustic return signal; and optical window located at the distal end of the probe; light path adapted to direct light from the and second light sources to the optical window of the probe and a volume of tissue; first sensor adapted to measure at least a portion of the light having a first predominant wavelength transmitted along an auxiliary light path; second sensor adapted to measure at least a portion of the light having a second predominant wavelength transmitted along the auxiliary light path; data acquisition subsystem includes one or more processors adapted to sample the ultrasound transducer array for optoacoustic return signals from the volume of tissue during a period of time after a pulse of light and to store sampled data associated with the optoacoustic return signals as a sinogram; data processing subsystem adapted to reconstruct an optoacoustic image based on sampled data stored as the sinogram, the data processing subsystem comprises software for; computing a normalization factor based on a measurement made by at least one of the first sensor and the second sensor during a pulse of light, wherein the normalization factor normalizes an energy deviation of the pulse of light with respect to a calibrated reference level for each of the first and second light sources; and applying the normalization factor to at least one of the sampled data, the first optoacoustic image or the second optoacoustic image; and display monitor adapted to display optoacoustic imagery. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 21, 22, 24, 25)
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Specification