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Interframe energy normalization in an optoacoustic imaging system

  • US 10,285,595 B2
  • Filed: 09/19/2016
  • Issued: 05/14/2019
  • Est. Priority Date: 11/02/2011
  • Status: Active Grant
First Claim
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1. An optoacoustic imaging system comprising:

  • a light subsystem having a first and a second light source the first light source configured to generate at least one pulse of light at a first predominant wavelength and the second light source configured to generate at least one pulse of light at a second predominant wavelength;

    a probe having a distal end and a proximal end, the probe comprising;

    i) ultrasound transducer array having an active end located at the distal end of the handheld probe, the ultrasound transducer array capable of receiving an optoacoustic return signal; and

    ii) optical window located at the distal end of the probe;

    light path adapted to direct light from the first and second light sources to the optical window of the probe and a volume of tissue;

    at least one sensor adapted to measure a portion of the light transmitted along the light path;

    data acquisition subsystem adapted to sample the ultrasound transducer array for optoacoustic return signals from the volume of tissue during a predetermined period of time after a first pulse of light from the first light source and during a predetermined period of time after a second pulse of light from the second light source and to store sampled data associated with the optoacoustic return signals;

    image processing subsystem adapted to reconstruct a first optoacoustic image based on the sampled data corresponding to the first pulse of light from the first light source and to reconstruct a second optoacoustic image based on the sampled data corresponding to the second pulse of light from the second light source;

    energy normalizing subsystem adapted to compute a normalization factor based on a measurement from the at least one sensor and to apply the normalization factor to at least one of the sampled data, the first optoacoustic image or the second optoacoustic image, wherein the normalization factor is based upon normalizing energy deviation of the first and second pulses of light with respect to a calibrated reference level for each of the first and second light sources; and

    display for outputting at least one reconstructed optoacoustic image.

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