User feedback to controls ischemia monitoring ECG algorithm

• US 10,285,612 B2
• Filed: 08/31/2015
• Issued: 05/14/2019
• Est. Priority Date: 09/02/2014
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Gregg, Richard E., Hubert, Volker Manfred, Zhou, Sophia Huai, Babaeizadeh, Saeed
• Primary Examiner(s): Hulbert, Amanda K
• Assistant Examiner(s): Patel, Natasha
• Application Number:
  US15/507,429
• Publication Number:
  US 20170281277A1
• Time in Patent Office: 1,352 Days
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: A61B 5/7475 User input or interface means, e.g. keyboard, pointing device, joystick

Abstract

When detecting ischemia and/or myocardial infarction in a subject, electrocardiogram (ECG) segments are analyzed for elevated ST segments indicative of ischemia and/or infarction. To mitigate false positive alerts, an ECG segment comprising an elevated ST segment that triggers an alert is presented to a clinician for verification as being indicative of ischemia or infarction, or as being attributable to a confounding condition not indicative of ischemia or infarction. Clinician feedback is used to adjust an elevated ST segment detection algorithm to improve accuracy and mitigate false positive alerts.

Claims

1. A method of mitigating false positive alerts for ischemic ECG patterns in an electrocardiogram (ECG) indicative of ischemia or myocardial infarction, comprising:

receiving real-time ECG data;

measuring a level of noise associated with each of a plurality of ECG segments;

identifying a lowest-noise ECG segment, which has a lowest level of noise relative to other ECG segments in the plurality of ECG segments;

analyzing the lowest-noise ECG segment to detect one or more elevated ST segments therein;

upon detection of the one or more elevated ST segments, generating an alert;

presenting the lowest-noise ECG segment that triggered the alert to a user for review;

receiving user feedback regarding whether the alert is a false positive; and

adjusting an elevated ST segment detection algorithm as a function of the received user input such that elevated ST segments not indicative of ischemia or myocardial infarction are ignored.

2. The method according to claim 1, wherein the elevated ST segment is detected by comparing absolute ST elevation to a predetermined ST elevation threshold.

3. The method according to claim 1, wherein the elevated ST segment is detected by comparing relative ST elevation over predetermined time period to a predetermined ST elevation threshold.

4. The method according to claim 1, further comprising presenting a menu of selectable ST-elevating conditions on a user interface and receiving the user input via the user interface.

5. The method according to claim 1, wherein the selectable ST-elevating conditions include ischemia, myocardial infarction, and one or more confounding conditions that cause elevated ST segments but are not indicative of ischemia or myocardial infarction.

6. The method according to claim 5, wherein the one or more confounding conditions comprise at least one of:

left bundle branch block;

right bundle branch block;

intra-ventricular conduction defect;

benign early repolarization;

acute pericarditis; and

left ventricular hypertrophy.

7. The method according to claim 1, wherein the ECG patterns comprise one or more of:

elevated ST segments;

ST depression;

inverted T-waves;

pathologic Q-waves; and

reduced R-waves.

8. The method according to claim 1, further comprising:

determining at least one of patient condition being unstable such that invasive treatment for cardiac ischemia is not permitted, or that a non-invasive cardiac ischemia treatment comprises medication only;

continuing monitoring of the patient with no invasive intervention;

tracking ischemia status of the patient; and

providing one or more reports on ischemic burden, the reports comprising at least one of a time of ischemia onset and the duration of the ischemia.

9. A processor configured to execute the method according to claim 1.

10. A system that facilitates mitigating false positive alerts when monitoring ST elevation in an electrocardiogram (ECG) indicative of ischemia or myocardial infarction, comprising:

a noise measurer configured to receive real-time ECG data and measure a level of noise associated with each of a plurality of ECG segments;

a best periodic ECG identifier configured to receive the real-time ECG data and noise measurement information from the noise measurer, and identify a lowest-noise ECG segment, which has a lowest level of noise relative to other ECG segments in the plurality of ECG segments;

an ECG analyzer configured to analyze the lowest-noise ECG segment to detect one or more elevated ST segments therein;

an alert generator configured to generate an alert upon detection of the one or more elevated ST segments;

a user interface on which the lowest-noise ECG segment that triggered the alert is presented to a user for review and via which the alert generator receives user feedback regarding whether the alert is a false positive; and

a processor configured to adjust an elevated ST segment detection algorithm as a function of the received user input such that elevated ST segments not indicative of ischemia or myocardial infarction are ignored.

11. The system according to claim 10, wherein the alert generator is further configured to detect the elevated ST segment by comparing absolute ST segment elevation to a predetermined ST elevation threshold.

12. The system according to claim 10, wherein the alert generator is further configured to detect the elevated ST segment by comparing relative ST elevation over predetermined time period to a predetermined ST elevation threshold.

13. The system according to claim 10, wherein the processor is further configured to preset a menu, via the user interface, of selectable ST-elevating conditions, and to receive the user input via the user interface.

14. The system according to claim 10, wherein the selectable ST-elevating conditions include ischemia, myocardial infarction, and one or more confounding conditions that cause elevated ST segments but are not indicative of ischemia or myocardial infarction.

15. The system according to claim 14, wherein the one or more confounding conditions comprise at least one of:

a left bundle branch block;

a right bundle branch block;

an intra-ventricular conduction defect;

benign early repolarization;

acute pericarditis; and

left ventricular hypertrophy.

16. An alert generator device configured to generate alerts indicative of ischemia or myocardial infarction upon detection of elevated ST segments in an electrocardiogram (ECG), comprising:

at least one measurement buffer configured to receive current ECG segment measurements and elevated ST segment information;

an ST segment elevation change detector configured to receive the current ECG segment measurements and elevated ST segment information and receive delayed measurement and elevated ST segment information from the buffer for comparison;

an infarct and ischemia detector configured to receive the current ECG segment measurements and elevated ST segment information and detect an elevated ST segment;

a median filter configured to receive and combine ST elevation change information from the ST segment elevation change module and the detected elevated ST segment from the infarct and ischemia detection module, and generate an alert as a function of the received outputs; and

an infarct and ischemia noise scorer configured to generate a probability indicative of a likelihood that the detected elevated ST segment is indicative of an ischemic or infarction event and output a predetermined ECG sample segment to a user interface for user confirmation that the alert is not a false positive.

17. The alert generator device according to claim 16, further comprising a processor configured to preset a menu, via the user interface of selectable ST-elevating conditions, and to receive the user input via the user interface.

18. The alert generator device according to claim 16, wherein the selectable ST-elevating conditions include ischemia, myocardial infarction, and one or more confounding conditions that cause elevated ST segments but are not indicative of ischemia or myocardial infarction.

19. The alert generator of claim 16, wherein the at least one measurement buffer comprises a plurality of measurement buffers, each of which stores data for a different time scale.