Fatty-acid based particles

• US 10,285,964 B2
• Filed: 07/22/2016
• Issued: 05/14/2019
• Est. Priority Date: 03/10/2009
• Status: Expired due to Fees

• Current Assignee: Atrium Medical Corporation (Getinge AB)
• Original Assignee: Atrium Medical Corporation (Getinge AB)
• Inventors: Swanick, Thomas M., Ferraro, Joseph, Rogers, Lisa, Martakos, Paul
• Primary Examiner(s): Wax, Robert A
• Assistant Examiner(s): Helm, Caralynne E
• Application Number:
  US15/216,873
• Publication Number:
  US 20160324816A1
• Time in Patent Office: 1,026 Days
• Field of Search: None
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/20 having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
• CPC Class Codes: A61K 31/4353 ortho- or peri-condensed with heterocyclic ring systems
• CPC Class Codes: A61K 31/436 the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/4545 containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• CPC Class Codes: A61K 31/496 Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• CPC Class Codes: A61K 31/7028 Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
• CPC Class Codes: A61K 31/7036 having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
• CPC Class Codes: A61K 35/60 Fish, e.g. seahorses; Fish eggs
• CPC Class Codes: A61K 38/13 Cyclosporins
• CPC Class Codes: A61K 9/10 Dispersions; Emulsions A61K9/06 takes precedence; composition of dispersions, emulsions A61K47/00
• CPC Class Codes: A61K 9/145 with organic compounds
• CPC Class Codes: A61K 9/16 Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction A61K9/20 takes precedence if the final form is a tablet; microspheres with drug-free outer coating, microcapsules A61K9/50; mixture of different granules, microcapsules, (coated) microparticles A61K9/5084; nanoparticles A61K9/51
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/08 Materials for coatings
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.

Claims

1. A medical device, comprising:

a medical device structure; and

a coating formed on at least a portion of the medical device structure;

wherein the coating comprises fatty acid particles made from a method of forming fatty acid particles that comprises the steps of;

(a) associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and

(b) fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed, wherein the fatty acid particles comprise fatty acids cross-linked directly to each other by bonds formed during a curing process, wherein the source of the fatty acids is a fish oil and wherein the particles have a distribution of size of about 1-20 μ

m (v,0.1), 21-40 μ

m (v,0.5), and 41-150 μ

m (v,0.9).

2. The medical device of claim 1, wherein the medical device structure is a vascular graft, hernia mesh, thin film, or stent.

3. Therapeutic fatty acid particles comprising fatty acids cross-linked directly to each other by bonds formed during a curing process, wherein the source of the fatty acids is a fish oil and wherein the particles have a distribution of size of about 1-20 μ

m (v,0.1), 21-40 μ

m (v,0.5), and 41-150 μ

m (v,0.9).

4. The particles of claim 3, further comprising a therapeutic agent.

5. A composition comprising the particles of claim 3 further combined with a fish oil.

6. A therapeutic film comprising pressed therapeutic particles, wherein the therapeutic particles are therapeutic fatty acid particles according to claim 3.

7. The therapeutic film of claim 6, wherein the therapeutic particles further comprise a therapeutic agent.

8. A method of treating an adhesion in a subject in need thereof, comprising administering to the subject the therapeutic fatty acid particles of claim 3.

9. The method of claim 8, wherein the fatty acid particles further comprise a therapeutic agent.

10. The method of claim 8, wherein the fatty acid particles are pressed into a film.

11. The particles of claim 3, wherein the mean particle size of the particles is in the range of about 1 micron to about 50 microns.