Drug delivery devices with drug-permeable component and methods
First Claim
Patent Images
1. A drug delivery device comprising:
- a compliant housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, wherein the drug reservoir lumen is closed such that no aperture extends through the housing; and
a drug contained in the drug reservoir lumen,wherein the first wall structure is impermeable to the drug, and the second wall structure is permeable to the drug,wherein the first wall structure and the second wall structure are adjacent one another and together form an elongated cylindrical tube, with the second wall structure extending along a length of the cylindrical tube, such that the first wall structure and the second wall structure together form an outer circumferential surface of the cylindrical tube along the length, andwherein the second wall structure, or both the first and second wall structures, are water permeable, such that the device is configured to release solubilized drug from the closed drug reservoir lumen by diffusion through only a material forming the second wall structure upon the drug being contacted by water that enters the drug reservoir lumen through the second wall structure or through both the first and second wall structures.
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Abstract
Implantable drug delivery devices include a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, and a drug contained in the drug reservoir lumen, wherein the first wall structure is impermeable to the drug and the second wall structure is permeable to the drug. Methods of providing controlled release of drug to a patient include deploying a drug delivery device in the patient releasing a drug from the drug reservoir lumen via diffusion through the second wall structure.
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Citations
21 Claims
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1. A drug delivery device comprising:
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a compliant housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, wherein the drug reservoir lumen is closed such that no aperture extends through the housing; and a drug contained in the drug reservoir lumen, wherein the first wall structure is impermeable to the drug, and the second wall structure is permeable to the drug, wherein the first wall structure and the second wall structure are adjacent one another and together form an elongated cylindrical tube, with the second wall structure extending along a length of the cylindrical tube, such that the first wall structure and the second wall structure together form an outer circumferential surface of the cylindrical tube along the length, and wherein the second wall structure, or both the first and second wall structures, are water permeable, such that the device is configured to release solubilized drug from the closed drug reservoir lumen by diffusion through only a material forming the second wall structure upon the drug being contacted by water that enters the drug reservoir lumen through the second wall structure or through both the first and second wall structures. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A device for intravesical insertion and controlled release of a drug into a urinary bladder of a patient, the device comprising:
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a housing which comprises a first wall structure and a second wall structure which are adjacent one another and together form a cylindrical tube, wherein the first and second wall structures together form an outer circumferential surface of the cylindrical tube, extend between opposed ends of the cylindrical tube, and bound a drug reservoir lumen that is closed such that no aperture extends through the housing; and a drug in a solid or semisolid form contained in the drug reservoir lumen, wherein; the first wall structure is impermeable to the drug, the second wall structure is permeable to the drug, the cylindrical tube is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra of the patient and into the urinary bladder and a retention shape suited to retain the device within the urinary bladder, and the second wall structure, or both the first and second wall structures, are water permeable, such that the device is configured to release solubilized drug from the closed drug reservoir lumen by diffusion through only a material forming the second wall structure upon the drug being contacted by water that enters the drug reservoir lumen through the second wall structure or through both the first and second wall structures. - View Dependent Claims (12, 13, 14, 15, 16)
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17. A drug delivery device comprising:
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a compliant housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure such that no aperture extends through the housing, wherein the first and second wall structures comprise coextruded thermoplastic polymers; and a drug contained in the drug reservoir lumen, wherein the first wall structure is water permeable and impermeable to the drug, and the second wall structure is permeable to the drug, wherein the first wall structure and the second wall structure are adjacent one another and together form an elongated tube, such that both the first and second wall structures bound the closed drug reservoir lumen and form an outer surface of the elongated tube, and wherein the second wall structure, or both the first and second wall structures, are water permeable, such that the device is configured to release solubilized drug from the closed drug reservoir lumen by diffusion through only a material forming the second wall structure upon the drug being contacted by water that enters the drug reservoir lumen through the second wall structure or through both the first and second wall structures. - View Dependent Claims (18, 19, 20, 21)
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Specification