Sulfur derivatives as chemokine receptor modulators
First Claim
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1. A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and individual isomers, tautomers or a pharmaceutically acceptable salt thereof:
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Abstract
The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
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9 Claims
- 1. A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and individual isomers, tautomers or a pharmaceutically acceptable salt thereof:
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7. A compound selected from the group consisting of:
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3- {[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]sulfonyl}-N,N- dimethylpropanamide; 3-[(4-chloro-2- {[(2,4-difluorophenyl)sulfonyl]amino}phenyl)thio]-N,N-dimethylpropanamide; 3-[(4-chloro-2- {[(2,4-difluorophenyl)sulfonyl]amino}phenyl)sulfinyl]-N,N-dimethylpropanamide; 3-[(4-chloro-2- {[(2,4-difluorophenyl)sulfonyl]amino}phenyl)sulfonyl]-N,N-dimethylpropanamide; 4-chloro-N- {5 -chloro-2-[(2-hydroxyethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide; 4-chloro-N- {5-chloro-2- [(pyridin-2-ylmethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide; 4-chloro-N- {5-chloro-2- [(pyridin-3-ylmethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide; 2- {[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}Iamino)phenyl]thio}-N,N-dimethylacetamide; 2- {[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl }amino)phenyl]thio}-N-methylacetamide; N- {2-[(2-aminoethyl)thio]-5-chlorophenyl}-4-chloro-3-(trifluoromethyl)benzenesulfonamide; N- {2-[(2-aminoethyl)sulfonyl]-5-chlorophenyl}-4-chloro-3-(trifluoromethyl)benzenesulfonamide N- {2-[(3-aminobenzyl)thio]-5-chlorophenyl}-2,4-difluorobenzenesulfonamide; N- {2-[(3-aminobenzyl)sulfonyl]-5-chlorophenyl}-2,4-difluorobenzenesulfonamide; N- {2-[(3-aminobenzyl)thio]-5-chlorophenyl}benzenesulfonamide; N- {2-[(3-aminobenzyl)thio]-5-chlorophenyl}-4-chlorobenzenesulfonamide; N- {2-[(3-aminobenzyl)sulfonyl]-5-chlorophenyl}benzenesulfonamide; N- {2-[(3-aminobenzyl)sulfinyl]-5-chlorophenyl}benzenesulfonamide; N- {2-[(3-aminobenzyl)sulfonyl]-5-chlorophenyl}-4-chlorobenzenesulfonamide; N- {2-[(3-aminobenzyl)sulfinyl]-5-chlorophenyl}-4-chlorobenzenesulfonamide; 3-{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thio}-N-isopropylpropanamide; 3-{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thio}-N,N-dimethylpropanamide; 3 -{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]sulfinyl}-N-isopropylprpanamide; 4-chloro-N-{5-chloro-2-[(1H-imidazol-2-ylmethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide; 4-chloro-N-{5-chloro-2-[(1H-imidazol-4-ylmethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide; and N-{2-[(3-aminobenzyl)sulfinyl]-5-chlorophenyl}-2,4-difluorobenzenesulfonamide. - View Dependent Claims (9)
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8. A pharmaceutical composition comprising as active ingredient a therapeutically effective amount of a compound selected from the group consisting of:
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3-{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]sulfonyl}-N,N-dimethylpropanamide; 3-[(4-chloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)thio]-N,N-dimethylpropanamide; 3-[(4-chloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)sulfinyl]-N,N-dimethylpropanamide; 3-[(4-chloro-2- {[(2,4-difluorophenyl)sulfonyl]amino}phenyl)sulfonyl]-N,N-dimethylpropanamide; 4-chloro-N- {5-chloro-2-[(2-hydroxyethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide; 4-chloro-N- {5-chloro-2-[(pyridin-2-ylmethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide; 4-chloro-N- {5-chloro-2-[(pyridin-3-ylmethyl)thio]phenyl}-3 -(trifluoromethyl)benzenesulfonamide; 2- {[4-chloro-2-({[4-chloro-3 -(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thio}-N,N-dimethylacetamide; 2- {[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thio}-N-methylacetamide; N- {2-[(2-aminoethyl)thio]-5-chlorophenyl}-4-chloro-3-(trifluoromethyl)benzenesulfonamide; N- {2-[(2-aminoethyl)sulfonyl]-5-chlorophenyl}-4-chloro-3-(trifluoromethyl)benzenesulfonamide; N- {2-[(3-aminobenzyl)thio]-5-chlorophenyl}-2,4-difluorobenzenesulfonamide; N- {2-[(3-aminobenzyl)sulfonyl]-5-chlorophenyl }-2,4-difluorobenzenesulfonamide; N- {2-[(3-aminobenzyl)thio]-5-chlorophenyl}benzenesulfonamide; N- {2-[(3-aminobenzyl)thio]-5-chlorophenyl}-4-chlorobenzenesulfonamide; N-{2-[(3-aminobenzyl)sulfonyl]-5-chlorophenyl}Ibenzenesulfonamide; N-{2-[(3-aminobenzyl)sulfinyl]-5-chlorophenyl}Ibenzenesulfonamide; N- {2-[(3-aminobenzyl)sulfonyl]-5-chlorophenyl}-4-chlorobenzenesulfonamide; N- {2-[(3-aminobenzyl)sulfinyl]-5-chlorophenyl}-4-chlorobenzenesulfonamide; 3- {[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl }amino)phenyl]thio}-N-isopropylpropanamide; 3-{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thio}-N,N-dimethylpropanamide; 3-{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]sulfinyl}-N-isopropylpropanamide; 4-chloro-N- {5-chloro-2-[(1H-imidazol-2-ylmethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide; 4-chloro-N- {5-chloro-2-[(1H-imidazol-4-ylmethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide; and N- {2-[(3-aminobenzyl)sulfinyl]-5 -chlorophenyl}-2,4-difluorobenzenesulfonamide; and a pharmaceutically acceptable adjuvant, diluent or carrier.
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Specification