Calibration method for the prospective calibration of measuring equipment
First Claim
1. A method for operating measuring equipment for detecting at least one analyte in a bodily fluid, the measuring equipment including a continuously monitoring sensor and a reference measurement sensor, the method comprising:
- implanting the continuously monitoring sensor into the skin of a patient;
detecting at least three calibration points, each calibration point comprising (i) a measurement signal obtained from the implanted sensor and corresponding to the concentration of the analyte in the bodily fluid and (ii) a reference value obtained using the reference measurement sensor, wherein the reference value corresponds to an actual present value of concentration of the analyte in the bodily fluid;
establishing a plurality of possible slopes between the calibration points;
using a robust estimation method to determine a probable slope from the plurality of possible slopes, the robust estimation method comprising a statistical estimation method which supplies stable statistical estimators even if outliers occur or if distribution assumptions are only approximately valid, the robust estimation being based on one or more permutation algorithms and/or on one or more sorting algorithms;
determining through a plurality of the calibration points a plurality of straight lines having the probable slope; and
using the continuously monitoring sensor to perform at least one measurement in which the probable slope is used with the measurement equipment to determine a concentration of the analyte in the bodily fluid.
3 Assignments
0 Petitions
Accused Products
Abstract
A method for operating measuring equipment for detecting at least one analyte in a bodily fluid by means of at least one continuously measuring blood glucose sensor. At least one calibration method is carried out for the prospective calibration of the measuring equipment. At least three calibration points are detected in the calibration method, wherein each calibration point comprises at least one measurement signal from the measuring equipment and at least one reference value of an associated reference measurement. A plurality of possible slopes are established between the calibration points. At least one robust estimation method, more particularly using a formation of at least one median, is used to determine at least one probable slope from the plurality of possible slopes. Furthermore, at least one measurement is carried out. During the measurement and using the probable slope, a concentration of the analyte in the bodily fluid is deduced from at least one measurement signal from the measuring equipment and the probable slope.
-
Citations
28 Claims
-
1. A method for operating measuring equipment for detecting at least one analyte in a bodily fluid, the measuring equipment including a continuously monitoring sensor and a reference measurement sensor, the method comprising:
-
implanting the continuously monitoring sensor into the skin of a patient; detecting at least three calibration points, each calibration point comprising (i) a measurement signal obtained from the implanted sensor and corresponding to the concentration of the analyte in the bodily fluid and (ii) a reference value obtained using the reference measurement sensor, wherein the reference value corresponds to an actual present value of concentration of the analyte in the bodily fluid; establishing a plurality of possible slopes between the calibration points; using a robust estimation method to determine a probable slope from the plurality of possible slopes, the robust estimation method comprising a statistical estimation method which supplies stable statistical estimators even if outliers occur or if distribution assumptions are only approximately valid, the robust estimation being based on one or more permutation algorithms and/or on one or more sorting algorithms; determining through a plurality of the calibration points a plurality of straight lines having the probable slope; and using the continuously monitoring sensor to perform at least one measurement in which the probable slope is used with the measurement equipment to determine a concentration of the analyte in the bodily fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
-
-
18. Measuring equipment for detecting at least one analyte in a bodily fluid, comprising:
-
a continuously measuring bodily fluid analyte sensor adapted for implanting into the skin of a patient; a processor having a program stored in memory and configured for execution by the processor, the program including instructions for; detecting at least three calibration points, each calibration point comprising (i) a measurement signal obtained from the continuously measuring sensor implanted in a patient, the measurement signal corresponding to the concentration of the analyte in the bodily fluid and (ii) a reference value obtained using a reference measurement sensor, wherein the reference value corresponds to an actual present value of concentration of the analyte in the bodily fluid; establishing a plurality of possible slopes between the calibration points; using a robust estimation method to determine a probable slope from the plurality of possible slopes, the robust estimation method comprising a statistical estimation method which supplies stable statistical estimators even if outliers occur or if distribution assumptions are only approximately valid, the robust estimation being based on one or more permutation algorithms and/or on one or more sorting algorithms; determining through a plurality of the calibration points a plurality of straight lines having the probable slope; and using the implanted sensor to perform at least one measurement in which the probable slope is used with the measurement equipment to determine a concentration of the analyte in the bodily fluid. - View Dependent Claims (19)
-
-
20. A method for operating measuring equipment for measuring concentration of an analyte in a bodily fluid, the measuring equipment including a continuously monitoring sensor, a reference measurement sensor, and a user interface, the method comprising:
-
implanting the continuously monitoring sensor into the skin of a patient; initially calibrating the continuously monitoring sensor using measurement signals obtained from the implanted sensor that are matched to respective reference values obtained with the reference measurement sensor; using the calibrated sensor to continuously monitor the concentration of the analyte in the patient'"'"'s bodily fluid; when a signal monitored from the calibrated sensor falls within a region that has less than a minimum number of calibration points, the user interface generates a visual, audible or haptic signal to the patient to recalibrate the continuously monitoring sensor; and recalibrating the sensor based on the visual, audible or haptic signal. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28)
-
Specification