Method and apparatus for non-contact axial particle rotation and decoupled particle propulsion

• US 10,290,404 B2
• Filed: 11/02/2015
• Issued: 05/14/2019
• Est. Priority Date: 10/31/2014
• Status: Active Grant

• Current Assignee: Weinberg Medical Physics, LLC
• Original Assignee: Weinberg Medical Physics, LLC
• Inventors: Mair, Lamar Odell, Nacev, Aleksandar Nelson, Weinberg, Irving N.
• Primary Examiner(s): Musleh, Mohamad A
• Application Number:
  US14/930,126
• Publication Number:
  US 20160125994A1
• Time in Patent Office: 1,289 Days
• CPC Class Codes: A61N 1/406 using implantable thermoseeds or injected particles for localized hyperthermia preparations of seeds and particles A61K41/0052
• CPC Class Codes: B82B 3/0066 Orienting nanostructures
• CPC Class Codes: H01F 1/00 Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
• CPC Class Codes: H01F 13/00 Apparatus or processes for magnetising or demagnetising devices for holding workpieces using magnetic or electric force acting directly on the workpieces B23Q3/15 ; for degaussing ships B63G9/06; for clocks or watches G04D9/00; recording or erasing of information on magnetic record carriers G11B5/00 ; demagnetising arrangements for colour television H04N9/29
• CPC Class Codes: H01F 7/0278 for generating uniform fields, focusing, deflecting electrically charged particles for magnetic separation by Lorentz force B03C1/023; specially adapted for NMR applications G01R33/383
• CPC Class Codes: H01F 7/20 without armatures cores H01F3/00; coils H01F5/00 ; shaping metal by applying magnetic forces B21D26/14; electromagnets specially adapted for NMR applications G01R33/381
• CPC Class Codes: H02N 15/00 Holding or levitation devices using magnetic attraction or repulsion, not otherwise provided for electric or magnetic devices for holding work on machine tools B23Q3/15 ; monorail vehicle propulsion or suspension B60L13/00; sliding or levitation devices for railway systems B61B13/08; material handling devices associated with conveyors incorporating devices with electrostatic or magnetic grippers B65G47/92; separating thin or filamentary articles from piles using magnetic force B65H3/16; delivering thin or filamentary articles from magnetic holders by air blast or suction B65H29/24; bearings using magnetic or electric supporting means F16C32/04; relieving bearing loads using magnetic means F16C39/06; magnets H01F7/00; dynamo-electric clutches or brakes H02K49/00 ; electric furnaces with simultaneous levitation and heating H05B6/32

Abstract

An apparatus and method for magnetic particle manipulation enables the particle to be rotated and translated independently using magnetic fields and field gradients, which produce the desired decoupled translational and rotational motion. The apparatus and the method for manipulation may be implemented in parallel, involving many particles. The rotational magnetic field used to induce rotational motion may be varied to induce particle motion, which is either in phase or out of phase with the rotational magnetic field. The magnetic fields and gradients described herein may be generated with permanent magnets, electromagnets, or some combination of permanent magnets and electromagnets.

Claims

1. An apparatus for rotating and translating at least one particle, the apparatus comprising:

means for generating magnetic force and torque; and

at least one particle,

wherein at least some portion of the at least one particle contains a magnetizable material,

wherein the generated magnetic force is applied to at least some portion of the at least one particle to cause translational motion of the particle,

wherein the generated magnetic torque is applied to at least some other portion of the same at least one particle to cause rotation of the particle,

wherein magnetic torque causing rotation of the at least one particle is decoupled from the magnetic force causing translational motion of the at least one particle, and

wherein the ratio of the translational and rotational velocities of the particle is variable.

2. The apparatus of claim 1, wherein the particle is introduced in a body, and a ratio of the translational and rotational velocities of the particle is varied while the particle is in the body.

3. The apparatus of claim 1, wherein the means for generating magnetic force includes means for generating a rotational field ranging from 1 Hz to 1000 Hz.

4. The apparatus of claim 1, wherein the at least one particle is composed of polymeric, metallic, insulating, semiconducting, ceramic, or combinations of at least two of these materials.

5. The apparatus of claim 1, wherein the at least one particle houses electronics, molecules/drugs, proteins, cells, or energy scavenging components.

6. The apparatus of claim 1, wherein at least one of the rotation of the at least one particle and the decoupled translational motion of the at least one particle are implemented in conjunction with the production and application of magnetic fields to apply repulsive and/or propulsive forces so as to manipulate the at least one particle.

7. The apparatus of claim 1, wherein manipulation of the at least one particle is performed by setting up appropriate magnetic gradient fields with or without pre-polarizing pulses.

8. The apparatus of claim 1, wherein the at least one particle is one of a plurality of particles, wherein each particle of the plurality of particles includes some portion or component that contains a magnetizable material, wherein magnetic torque causing rotation of each of the plurality of particle is decoupled from the magnetic force causing translational motion.

9. The apparatus of claim 1, further comprising a solution that contains a plurality of particles including the at least one particle, wherein each particle of the plurality of particles includes some portion or component that contains a magnetizable material, wherein magnetic torque causing rotation of each of the plurality of particle is decoupled from the magnetic force causing translational motion.

10. The apparatus of claim 1, where an amplitude and frequency of a magnetic field causing rotation of the at least one particle is independent of an amplitude and frequency of a magnetic gradient that is causing translation of the at least one particle.

11. A method for rotating and translating at least one particle, the method comprising:

generating and applying a magnetic force and torque upon at least one particle, wherein the at least one particle includes at least two segments, each of which contains a magnetizable material;

applying the magnetic force to at least one segment in order to cause translational motion of the particle; and

applying the magnetic torque to at least one other segment in order to cause rotational motion of the particle,

wherein magnetic torque causing rotation of the at least one particle is decoupled from the magnetic force causing translational motion of the at least one particle, and

wherein a ratio of the resultant translational and rotational velocities of the particle is variable.

12. The method of claim 11, wherein the particle is introduced in a body, and a ratio of the translational and rotational velocities of the particle is varied while the particle is in the body.

13. The method of claim 11, wherein the generation of the magnetic force generates a rotational field ranging from 1 Hz to 1000 Hz.

14. The method of claim 11, wherein the at least one particle is composed of polymeric, metallic, insulating, semiconducting, ceramic, or combinations of at least two of these materials.

15. The method of claim 11, wherein the at least one particle houses electronics, molecules/drugs, proteins, cells, or energy scavenging components.

16. The method of claim 11, wherein at least one of the rotation of the at least one particle and the decoupled translational motion of the at least one particle are implemented in conjunction with the production and application of magnetic fields to apply repulsive and/or propulsive forces so as to manipulate the at least one particle.

17. The method of claim 11, wherein manipulation of the at least one particle is performed by setting up appropriate magnetic gradient fields with or without pre-polarizing pulses.

18. The method of claim 11, wherein the at least one particle is one of a plurality of particles, wherein each particle of the plurality of particles includes some portion or component that contains a magnetizable material, wherein magnetic torque causing rotation of each of the plurality of particle is decoupled from the magnetic force causing translational motion.

19. The method of claim 11, wherein a solution that contains a plurality of particles including the at least one particle, wherein each particle of the plurality of particles includes some portion or component that contains a magnetizable material, wherein magnetic torque causing rotation of each of the plurality of particle is decoupled from the magnetic force causing translational motion.

20. The method of claim 11, wherein an amplitude and frequency of a magnetic field causing rotation of the at least one particle is independent of an amplitude and frequency of a magnetic gradient that is causing translation of the at least one particle.

21. A particle comprising:

at least two magnetic segments,

wherein at least one of the at least two magnetic segments has a length at least twice the diameter of the particle and is magnetized parallel to a major axis of the particle,

wherein at least one other segment of the at least two magnetic segments has a length that is less than the diameter of the particle and is magnetized perpendicular to the major axis of the particle,

wherein magnetization and dimensions of the at least two magnetic segments of the particle configure the particle to be independently rotated and translated in response to application of external magnetic gradients to the particle such that magnetic torque causing rotation of the particle is decoupled from the magnetic force causing translational motion of the particle, and

wherein the ratio of the translational and rotational velocities of the particle is variable.

22. The particle of claim 21, wherein the at least one other segment of the particle is configured to lose magnetization after removal of the magnetic field.

23. The particle of claim 21, wherein the particle is a cylinder and further comprises a non-magnetic material positioned between and separating the at least two magnetic segments along the cylinder major axis.