Non-invasive health indicator monitoring system and using method thereof

• US 10,292,586 B2
• Filed: 11/11/2014
• Issued: 05/21/2019
• Est. Priority Date: 01/20/2014
• Status: Active Grant

• Current Assignee: Korea Advanced Institute of Science and Technology
• Original Assignee: Korea Advanced Institute of Science and Technology
• Inventors: Song, Yong Won, Lee, Su Youn, Lee, Ji Yeon, Lim, Jung Ah, Choi, Ji Won, Cheong, Byung Ki, Kim, Jin Seok, Jang, Ho Seong, Yi, Hyun Jung
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): Catina, Michael A
• Application Number:
  US14/538,206
• Publication Number:
  US 20150201837A1
• Time in Patent Office: 1,652 Days
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: H01M 10/00 Secondary cells; Manufacture thereof
• CPC Class Codes: H01M 10/0525 Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
• CPC Class Codes: H01M 10/058 Construction or manufacture
• CPC Class Codes: H01M 2220/30 Batteries in portable systems, e.g. mobile phone, laptop
• CPC Class Codes: H01M 50/202 Casings or frames around the primary casing of a single cell or a single battery
• CPC Class Codes: H01M 50/247 specially adapted for portable devices, e.g. mobile phones, computers, hand tools or pacemakers
• CPC Class Codes: Y02E 60/10 Energy storage using batteries

Abstract

The present invention relates to a non-invasive health indicator monitoring system including a sensing module, an electric power storage module, and a circuit module to collect health indicator information by contacting with a subject. In addition, the present invention also relates to a method for monitoring health indicator continuously by using the health indicator monitoring system.

Claims

1. A noninvasive health indicator monitoring system for use in collecting at least one health indicator information, comprising

a sensing module to collect health indicator information obtained from at least one health indicator marker wherein the sensing module includes an enzymatic amperometric sensor comprising:

glucose oxidase, and

horseradish peroxidase (HRP) combined onto an M13 virus in which the combined HRP-M13 virus is bound to a carbon nanotube;

a power storage module located on a support board to provide electric power to the sensing module continuously; and

a circuit module connected with the sensing module and the power storage module respectively to drive the sensing module, save or transmit the collected health indicator information, and control power supply of the system.

2. The noninvasive health indicator monitoring system according to claim 1, wherein the circuit module comprises a sensor driving part to drive the sensing module, a data control part to control the health indicator information, a transmission part to deliver the health indicator information to an external device.

3. The noninvasive health indicator monitoring system according to claim 1, further comprising a power generation module which is electrically connected with the power storage module.

4. The noninvasive health indicator monitoring system according to claim 1, wherein the system comprises multilayer structure comprising a first, a second, and a third layer;

the first layer is configured to be in contact with the subject;

the second layer is located on the first layer and comprises the power storage module and the circuit module; and

the third layer is located on the second layer and comprises the sensing module,

wherein the multilayer structure is at least partially transparent and generally flexible;

has a shape of contact lens; and

is located between the eyeball and the eyelid in a driving mode.

5. The noninvasive health indicator monitoring system according to claim 4, wherein the power generation module is on the third layer.

6. The noninvasive health indicator monitoring system according to claim 5,

wherein the power generation module comprises a triboelectric nanogenerator that comprises one nano structure selected from the group consisting of PDMS, polymeric nanostructure and the combinations thereof.

7. The noninvasive health indicator monitoring system according to claim 4, wherein the health indicator information is blood glucose level and the health indicator marker is tear glucose level.

8. The noninvasive health indicator monitoring system according to claim 4, wherein the health indicator marker is one selected from the group consisting of glucose level, glycated albumin level, fructosamine level, 1,5-anhydroglucitol level, uric acid level, lactic acid level, pyruvate level, and ascorbate level.

9. The noninvasive health indicator monitoring system according to claim 4, wherein the sensing module, the power generation module, the power storage module and the circuit module are connected together though interconnect and the interconnect is biocompatible, flexible and transparent interconnect or micro interconnect having the line width of no more than 50 μ

m.

10. The noninvasive health indicator monitoring system according to claim 9, wherein the interconnect comprises one selected from the group consisting of conductive nanoparticle, nanosized metal structure, oxide semiconductor, conductive polymer, carbon nanotube, and graphene.

11. The noninvasive health indicator monitoring system according to claim 4, wherein the power storage module comprises a laminated flexible thin film battery.

12. The noninvasive health indicator monitoring system according to claim 11, wherein the laminated flexible thin film battery comprises a transparent cathode material, a transparent electrolyte, and a transparent anode material.

13. The noninvasive health indicator monitoring system according to claim 1,

wherein the sensing module further comprises a filter to filter proteins and the enzymatic amperometric sensor is configured to quantify the health indicator marker from a body fluid filtered through the filter;

the circuit module connected with the sensing module obtains the health indicator information and saves and transmits the obtained health indicator information; and

the sensing module comprises a multi-sensor array.

14. The noninvasive health indicator monitoring system according to claim 4, wherein the system has a thickness of no more than 300 μ

m;

comprises a light transmission part comprising micro interconnect which is transparent; and

the light transmission part has a diameter of 0.5˜

2 mm.

15. The noninvasive health indicator monitoring system according to claim 1,

wherein a carboxylic acid functional group (—

COOH) of the horseradish peroxidase (HRP) is combined with an amine group (—

NH2) of a protein of the M13 virus using 1-ethyl 1-3-(3-dimethylaminopropyl) carboimide and N-hydroxysulfosuccinimide.

16. The noninvasive health indicator monitoring system according to claim 13, wherein the sensing module further comprises metal nanoparticles selected from the group consisting of Au, Pt and the combination thereof.

17. The noninvasive health indicator monitoring system according to claim 4, wherein the supporting substrate in the multilayer structure comprises a soft hydrogel material, the multilayer structure further comprises a protective layer covering whole of the multilayer structure, and the protective layer further comprises one selected from the group consisting of HEMA, soft hydrogel, silicone acrylate, and fluoro-silicone acrylate.

18. The noninvasive health indicator monitoring system according to claim 1, wherein the power storage module is supplied with energy in wireless charging manner.

19. The noninvasive health indicator monitoring system according to claim 18, wherein the wireless charging manner is magnetic resonance.

20. A contact lens comprising:

a first layer;

a second layer on the first layer, wherein the second layer comprises;

a sensor driving module, and

a circuit module electrically coupled to the sensor driving module; and

a third layer on the second layer, wherein the third layer comprises;

an inlet pumping chamber fluidly coupled to a tear inlet,

a sensor chamber fluidly coupled to the inlet pumping chamber;

an enzymatic amperometric sensor electrically coupled to the sensor driving module and to the circuit module, wherein the enzymatic amperometric sensor comprises;

glucose oxidase, and

horseradish peroxidase (HRP) combined onto an M13 virus in which the combined HRP-M13 virus is bound to a carbon nanotube; and

a outlet pumping chamber fluidly coupled to the sensor chamber and fluidly coupled to a tear outlet.

21. The contact lens of claim 20, wherein the second layer further comprises an energy harvesting device electrically coupled to the circuit module.

22. The contact lens of claim 20, wherein the second layer further comprises a thin film battery electrically coupled to the sensor driving module and electrically coupled to the circuit module.

23. The contact lens of claim 20, wherein the third layer further comprises a power generation module electrically coupled to the sensor driving module, to the circuit module, and to the sensor chamber.

24. The contact lens of claim 20, wherein the contact lens is configured to collect at least one health indicator information when in contact with an eye of a subject.

25. The contact lens of claim 20, wherein the third layer further comprises a power generation module;

and the second layer further comprises a power storage module which is electrically coupled to the power generation module, to the enzymatic amperometric sensor, to the sensor driving module, and to the circuit module.

26. The contact lens of claim 20, wherein the first, second, and third layers are at least partially transparent.

27. The contact lens of claim 25, wherein the power generation module is selected from the group consisting of thin film type solar cell, a piezoelectric nanogenerator, and a triboelectric nanogenerator.

28. The contact lens of claim 27 wherein the thin film type solar cell is selected from the group consisting of a quantum dot photoelectronic (QDP) device selected from the group consisting of a SnS QDP device, a CuInSe QDP device, a CuS QDP device, and a FeS QDP device.

29. The contact lens of claim 27 wherein the piezoelectric nanogenerator comprises a nano structure of lead-free piezoelectric nano wire selected from the group consisting of ZnO, NKN, BaTiO3, and combinations thereof.

30. The contact lens of claim 27, wherein the triboelectric nanogenerator comprises one nano structure selected from the group consisting of PDMS, polymeric nanostructure, and the combinations thereof.

31. The contact lens of claim 24, wherein the health indicator information is selected from the group consisting of glucose level, glycated albumin level, fructosamine level, 1,5-anhydroglucitol level, uric acid level, lactic acid level, pyruvate level, ascorbate level, and the combinations thereof.

32. The contact lens of claim 20, wherein the sensing module, the power generation module, the power storage module and the circuit module are connected together though interconnect and the interconnect is biocompatible, flexible and transparent interconnect or micro interconnect having line widths of no more than 50 μ

m.

33. The contact lens of claim 20, wherein a carboxylic acid functional group (—

COOH) of the horseradish peroxidase (HRP) is combined with an amine group (—

NH2) of a protein of the M13 virus using 1-ethyl 1-3-(3-dimethylaminopropyl) carboimide and N-hydroxysulfosuccinimide.

34. A contact lens comprising:

an enzymatic amperometric sensor that includes;

glucose oxidase, and

horseradish peroxidase (HRP) combined onto an M13 virus in which the combined HRP-M13 virus is bound to a carbon nanotube;

a sensor driving module electrically coupled to the enzymatic amperometric sensor,

a circuit module electrically coupled to the sensor driving module;

a power storage module electrically coupled to the sensor driving module and to the circuit module;

a tear inlet;

an inlet pumping chamber fluidly coupled to the tear inlet;

a sensor chamber fluidly coupled to the inlet pumping chamber in which the enzymatic amperometric sensor is at least partially contained therein;

outlet pumping chamber fluidly coupled to the sensor chamber; and

a tear outlet fluidly coupled to the outlet pumping chamber.

35. The contact lens of claim 34, wherein a carboxylic acid functional group (—

COOH) of the horseradish peroxidase (HRP) is combined with an amine group (—

NH2) of a protein of the M13 virus using 1-ethyl 1-3-(3-dimethylaminopropyl) carboimide and N-hydroxysulfosuccinimide.

36. The contact lens of claim 34, further comprising an energy harvesting device electrically coupled to the circuit module.

37. The contact lens of claim 34, further comprising a filter fluidly coupled between the sensor chamber and the tear inlet.