Imaging device and method for optoacoustic imaging of small animals

• US 10,292,593 B2
• Filed: 07/23/2010
• Issued: 05/21/2019
• Est. Priority Date: 07/27/2009
• Status: Active Grant

• Current Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für. Gesundheit und Umwelt (GmbH)
• Original Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für. Gesundheit und Umwelt (GmbH)
• Inventors: Razansky, Daniel, Ntziachristos, Vasilis
• Primary Examiner(s): Gillman, Amelie R
• Application Number:
  US13/386,491
• Publication Number:
  US 20120220851A1
• Time in Patent Office: 3,224 Days
• Field of Search: 600407, 600437, 600476
• CPC Class Codes: A61B 2503/40 Animals
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 6/508 for non-human patients
• CPC Class Codes: A61B 8/13 Tomography A61B8/10, A61B8/12 take precedence; tomography for radiation diagnosis A61B6/02
• CPC Class Codes: G01N 2021/1787 Tomographic, i.e. computerised reconstruction from projective measurements
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids
• CPC Class Codes: G01N 21/39 using tunable lasers
• CPC Class Codes: G01N 2201/0826 Fibre array at source, distributing

Abstract

An imaging device configured for optoacoustic imaging of an object, including an illumination device including optical components arranged to illuminate the object, a detector device comprising an array of detector elements arranged in a tank and arranged to detect acoustic signals created in the object, and a container device including a tank arranged to accommodate the detector device, the object and a matching transmission medium, a holding device adapted to position and move the object relative to the illumination device and the detector device, wherein the optical components are arranged in the tank to illuminate the object from different directions.

Claims

1. An imaging device configured for optoacoustic imaging of an object, comprising:

an illumination device comprising optical components and a laser source, the laser source being configured to illuminate the object via the optical components from different directions, so that an illumination pattern is formed upon the object, the optical components comprising optical fibers;

a detector device comprising an array of detector elements configured to detect acoustic signals created in the object in response to illuminating the object, wherein the shape of the array of detector elements is an arc having a center of curvature, the center of curvature lying within the object during imaging of the object, and wherein the detector elements are disposed such that they are focused into a predetermined 2D detection plane through which the object is imaged upon use of the imaging device;

a container device accommodating the optical components, the detector device, and a matching transmission medium;

a motor; and

a membrane and a frame-shaped holding element to which the membrane is attached, the membrane forming a bag configured to support the object from below and configured to immerse the object in the matching transmission medium, whereby the membrane separates the object and the matching transmission medium from each other such that the object has no direct contact with the matching transmission medium, the frame-shaped holding element being supported by a guide rail located in the container device, the frame-shaped holding element including a plurality of wheels configured to run on the guide rail, the motor configured to move the frame-shaped holding element relative to the container device, the illumination device, and the detector device along a path of translation movement, the path of translation movement being perpendicular to the predetermined 2D detection plane, wherein output ends of the optical fibers are facing to the object and surrounding the membrane and the object, and wherein the arc-shaped array of detector elements partially surrounds the object and the membrane while the membrane with the object is moved relative to the illumination device and the array of detector elements along the path of translation movement.

2. The imaging device according to claim 1, wherein the detector elements comprise at least one of piezoelectric film detector elements and film detector elements adapted for interferometric signal recording.

3. The imaging device according to claim 1, wherein the illumination pattern formed upon the object is a ring type pattern.

4. The imaging device according to claim 1, wherein the optical fibers comprise a fiber bundle having multiple arms arranged at equally spaced angles adding up to 360 degrees.

5. The imaging device according to claim 1, wherein the membrane is acoustically and optically matched to illuminate the object and detect the acoustic signals.

6. The imaging device according to claim 1, wherein the laser source comprises a tunable optical parameter oscillator laser including a tiltable non-linear crystal for wavelength scanning.

7. The imaging device according to claim 1, wherein the membrane is made of at least one of polyvinyl chloride plastisol, polyethylene, or latex.

8. The imaging device according to claim 1, wherein the membrane has a thickness below 1 mm.

9. The imaging device according to claim 1, wherein the illumination device and the detector device are configured to repeat illuminating the object and detecting acoustic signals for at least two different wavelengths in less than 2 seconds.

10. The imaging device according to claim 1, wherein the membrane forming the bag is a tube-shaped membrane, such that when the tube-shaped membrane is immersed in the matching transmission medium, ends of the tube-shaped membrane are located above the surface of the matching transmission medium.

11. The imaging device according to claim 1, further comprising a control device configured to actuate the motor to move the membrane with the object along the path of translation movement to stepwise adjust positions of the object relative to the 2D detection plane, to control the illumination device to repeatedly illuminate the object at each of the adjusted positions with at least two different wavelengths of illumination light, and to control the detector device to repeatedly detect acoustic signals created in the object at each of the adjusted positions in response to the repeated illuminating of the object with the at least two different wavelengths of the illumination light, and to reconstruct images of the object by analyzing the acoustic signals created in the object at each of the adjusted positions of the object in response to the repeated illuminating with the at least two different wavelengths, whereby a series of slice images of the object is obtained for each of the at least two different wavelengths.

12. The imaging device according to claim 1, wherein the output ends of the optical fibers are located on a circle line surrounding the membrane and the object.

13. An imaging device for optoacoustic imaging of an object, the imaging device comprising:

an illumination device comprising optical components and a laser source, the laser source configured to illuminate the object via the optical components from different directions such that an illumination pattern is formed on the object, the optical components comprising optical fibers;

a detector device comprising an array of detector elements configured to detect acoustic signals created in the object in response to illuminating the object, wherein the shape of the array of detector elements is an arc having a center of curvature, the center of curvature lying within the object during imaging of the object, wherein the detector elements of the array of detector elements are disposed such that they are focused into a predetermined 2D detection plane through which the object is imaged upon use of the imaging device;

a container device accommodating the optical components and the detector device;

a matching transmission medium disposed in the container device;

a frame-shaped element attached to a membrane, the membrane forming a bag to support the object from below, wherein the membrane is configured to immerse the object in the matching transmission medium, and wherein the membrane is further configured to separate the object and the matching transmission medium such that the object has no direct contact with the matching transmission medium;

a guide rail disposed in the container device, the guide rail supporting the frame-shaped element, the frame-shaped element including a plurality of wheels configured to run on the guide rail; and

a motor operatively coupled to the frame-shaped element, wherein upon actuation of the motor the motor is configured to move the frame-shaped element along the guide rail such that the membrane and the object move relative to the container device, the illumination device, and the array of detector elements along a path of translation movement, wherein the path of translation movement is perpendicular to the predetermined 2D detection plane, and wherein output ends of the optical fibers are facing to the object and surrounding the membrane and the object, and wherein the array of detector elements partially surrounds the object and the membrane while the membrane with the object is moved relative to the illumination device and the detector device.

14. The imaging device according to claim 13, wherein the output ends of the optical fibers are located on a circle line surrounding the membrane and the object.