Devices and methods for detection of internal bleeding and hematoma

• US 10,292,598 B2
• Filed: 12/12/2014
• Issued: 05/21/2019
• Est. Priority Date: 06/13/2012
• Status: Active Grant

• Current Assignee: Dean Nahman, Ilan Ben Oren, Shmuel Chen, Yaron Bar-Ilan, Yaron Ilan
• Original Assignee: Dean Nahman, Ilan Ben Oren, Shmuel Chen, Yaron Bar-Ilan, Yaron Ilan
• Inventors: Nahman, Dean, Ilan, Yaron, Ben Oren, Ilan, Bar-Ilan, Yaron, Chen, Shmuel
• Primary Examiner(s): Rozanski, Michael T
• Application Number:
  US14/569,396
• Publication Number:
  US 20150099980A1
• Time in Patent Office: 1,621 Days
• CPC Class Codes: A61B 2505/05 Surgical care
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/02042 Determining blood loss or bleeding, e.g. during a surgical procedure
• CPC Class Codes: A61B 5/0255 Recording instruments specially adapted therefor
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/4875 Hydration status, fluid retention of the body
• CPC Class Codes: A61B 5/6833 Adhesive patches

Abstract

A device for detection of internal bleeding in a patient'"'"'s body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.

Claims

1. A device for detection of internal bleeding in a patient'"'"'s body, the device comprising:

an IR light source configured to generate light in the Infra-Red (IR) spectral range;

an IR light detector configured to detect light in the Infra-Red (IR) spectral range;

an optical interface comprising

at least one first optical channel configured to transmit IR light generated by said IR light source through an area of a skin of said patient, into an internal layer of the body, and

one or more collection component, comprising at least one second optical channel, configured to collect reflected IR light from said area of said skin, and deliver said collected IR light to said IR light detector, and

a reference signal source configured to generate a Radio-Frequency (RF) reference signal at a frequency of about 0.5 MHz-3 MHz,

a reference signal detector configured to detect said reference signal,

a reference signal interface configured to directly and independently from the IR source deliver through said area of the skin of the patient the reference signal from said reference signal source into said internal layer and to collect and deliver a collected reference signal to said reference signal detector, and

a signal processing module comprising a processor configured to normalize measurement results of the detected IR light, detected by said IR detector, according to measurement results of the detected reference signal, detected by said reference signal detector, thereby detecting the internal bleeding in the patient'"'"'s body.

2. The device of claim 1 wherein said measurement results of said detected IR light comprise a measured parameter of said detected IR light selected from the group consisting of spectral line width, spectral content and spectral distribution of power.

3. The device of claim 1 wherein said signal processing module is configured to controllably modulate said IR light generated by said IR light source so that said at least one first optical channel delivers modulated IR light, and to modulate said collected IR light synchronously with said modulation of said generated IR light.

4. The device of claim 1 wherein said reference signal interface comprises a first electrical contact configured to be attached to said area of the skin, and said reference signal interface further comprises a second electrical contact configured to be attached to the skin at a location different from said area, wherein at least one of said first electrical contact and second electrical contact is functionally associated with said reference signal source for delivering said reference signal into said internal layer.

5. The device of claim 1 wherein said generated IR light comprises a Mid IR (MIR) light having a wavelength in a spectral range of 4-6 um.

6. The device of claim 1 wherein said at least one second optical channel of said one or more collection component comprises said at least one first optical channel.

7. The device of claim 6 wherein said one or more collection component comprises at least one optical fiber, respectively, configured to deliver said IR light generated by said IR light source, and to also deliver said collected IR light to said IR light detector.

8. The device of claim 7 wherein said one or more collection component comprises at least one lens optically associated with said at least one optical fiber so that said transmitted IR light and said collected IR light pass through said lens, wherein said lens has a diameter between 10 um and 2 mm.

9. The device of claim 6 wherein said one or more collection component comprises a waveguide assembly comprising a plurality of mirrors spatially separated across the waveguide assembly thereby being configured to transmit said generated IR light to a plurality of sub-areas, and to collect said reflected IR light from said plurality of subareas.

10. The device of claim 9 wherein said waveguide assembly comprises an array of optic fibers disposed in said waveguide assembly wherein each optic fiber is optically associated with one of said plurality of mirrors so that said IR light generated by said IR light source is delivered by said optic fibers and deflected by a respective mirror to each of said plurality of sub-areas, respectively, and said IR light reflected from each of said sub-areas is deflected by said respective mirror into said associated optic fiber to be delivered to said IR detector.

11. The device of claim 1, wherein said optical interface comprises a disposable adhesive pad configured for attaching said optical interface to said area of the skin.

12. A method for detecting the internal bleeding in the patient'"'"'s body, comprising:

providing the device of claim 1;

transmitting said transmitted IR light to the area of the skin of said patient, into the internal layer of the body;

collecting and detecting the IR light reflected from the area of the skin;

delivering the RF reference signal through the area of the skin of said patient, into the internal layer of the body;

collecting and detecting the reference signal from the body of the patient, and normalizing the measurement results of the detected IR light according to the measurement results of the detected reference signal, thereby detecting the internal bleeding in the patient'"'"'s body.

13. The method of claim 12 wherein said internal layer of the body of the patient is of one from the group consisting of a limb, abdominal cavity, chest cavity and digestive tract.